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Biomedical subjects

A Seki

Publications and source records attributed to A Seki.

At least 217 records · Page 12Linked to original sources
PubMed1975

Application to a radioimmunoassay for angiotensin I to the measurement of plasma renin in rabbits, and comparison with a biological assay of plasma renin activity.

A radioimmunoassay method for ileu-5-angiotensin I was applied to the measurement of plasma renin in rabbits. In the present method, the volume of plasma sample, required for the determination of plasma renin activity and plasma renin concentration, could be reduced to 0.6 ml and 0.05 ml, respectively. A satisfactory correlation (r = 0.918) was found between the plasma renin activity measured by our bioassay method reported previously and that by the present radioimmunoassay method in each of 25 different plasma samples. A highly significant correlation (r = 0.968) was also observed between the plasma renin activity and the plasma renin concentration, both of which were measured by radioimmunoassays, as far as renin concentration remained under 200 ng/ml/hr. On the other hand, the present results appear to indicate that, when a high plasma renin activity was obtained, it was difficult to evaluate the actual plasma renin concentration. Therefore, it would be necessary to be cautious to apply the method for plasma renin activity on the renin rich plasma.

Angiotensin II↗
PubMed1974

Effect of removing the clipped kidney on renovascular hypertension in rabbits.

Constriction of one renal artery in the presence of the opposite kidney can produce persistent hypertension which is often associated with increase in plasma renin activity, decrease in serum potassium and increase in water intake. In the present study the clipped kidney was removed in 15 hypertensive rabbits 12 to 54 weeks after the constriction. Blood pressure showed a prompt and transient fall which was followed by a slight rebound and subsequently a gradual decline. However, it still remained above the normal 5 weeks after removal. Removal of the clipped kidney resulted in return to normal of increased plasma renin activity, decreased serum potassium and increased water intake at the end of the postoperative first week.

Animals↗