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Biomedical subjects

A Seidel

Publications and source records attributed to A Seidel.

At least 199 records · Page 11Linked to original sources
PubMed1983

The metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies.

The metabolism of radiohafnium (175Hf + 181Hf) was studied in male Sprague-Dawley rats and Chinese hamsters for periods of up to 168 days. The results were compared with similar data for 239Pu in the same rat strain. In rats and hamsters the radiohafnium organ distribution was skeleton greater than skin greater than muscle greater than liver at about 7 days postinjection. Retention of radiohafnium and plutonium was similar in plasma and liver, as were the retention times observed for other organs: Absorption of radiohafnium from the gastrointestinal tract of rats was less than 0.05%. Biochemical studies showed that the radiohafnium was bound mainly to the iron-transport protein, transferrin, in blood plasma and in the liver cytosol of both the rat and the hamster, as has been observed also for plutonium. The metabolic behavior of radiohafnium mimics, to a large extent, that of plutonium, and it is suggested that radiohafnium can serve as a non-alpha-particle-emitting analog of plutonium for metabolic, biochemical, and selected human investigations.

Animals↗
PubMed1982

[The prognostic value of diastolic extra sounds].

Longitudinal examinations of 110 patient and ergometric loading tests on 300 patients resulted in correlative relations between diastolic extra sounds, increasing, reduction of the activity and decreased load capacity. On the basis of subjective and objective criteria the thesis is confirmed to value diastolic extra sounds as signs of an early insufficiency. It was conspicuous that already in adolescents with diastolic extra sounds a reduced load capacity could be established in comparison to adolescents of the same age.

Adolescent↗
PubMed1982

Thyroid hormones affect the physiological availability of nonshivering thermogenesis.

Hypothyroid hamsters had a reduced capacity for heat production in the cold. This was correlated with a reduction of nonshivering thermogenesis (NST) as measured following an injection of tyramine, thereby releasing endogenous stores of noradrenaline (NA). However, when NST was measured following an injection of NA, the same capacity was found in controls and hypothyroid hamsters. This suggests that hypothyroidism decreased the availability of endogenous transmitters for cold induced stimulation of NST.

Acclimatization↗
PubMed1982

Distribution and retention of 239Pu in the tree shrew (Tupaia belangeri) following intramuscular injection.

The retention of intramuscularly injected monomeric 239Pu has been studied in the tree shrew (Tupaia belangeri), a primitive prosimian species. Data for the first 2 yr are presented. Resorption from the injection site is rapid, and the main depository organs are skeleton and liver with approximately 50 and 20% of the absorbed dose, respectively. The half life of retention in skeleton is approximately 500-600 days and in liver approximately 150 days, these half lives are compared to data for the retention of transuranium elements in other animal species. Indications of liver lesions were found in 5 animals and 1 animal died at day 790 with an osteosarcoma.

Animals↗
PubMed1975

[Retention of 241Am in the rat and the Syrian hamster].

The retention of 241-Am during the first three months after injection as well as its microdistribution on the 2nd day were investigated in the rat and the Syrian hamster. Deposition, retention and microdistribution in the skeleton of both species are virtually identical; the same holds for kidneys, except for a higher initial deposition in the hamster. The microdistribution of 241-Am in kidneys and liver of both species is homogenous with a distinct accumulation in the cortical zone of the kidneys. A pronounced difference was observed with regard to the elimination of 241-Am from the liver: Most of the 241-Am is excreted by the rat liver with a half time of 7 days whereas this value is about 150 days for the Syrian hamster. The consequences of the species differences are discussed.

Americium↗