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Biomedical subjects

A Schulte

Publications and source records attributed to A Schulte.

48 records · Page 3Linked to original sources
PubMed1981

Effect of ursodeoxycholic acid on bile supersaturated with cholesterol in patients pretreated with clofibrate.

To clarify whether it is possible to compensate the lithogenic effect of clofibrate on bile without diminishing effect of clofibrate on bile without diminishing its therapeutic value, studies have been performed in 15 patients with hyperlipoproteinaemia. They received clofibrate (1.5 g/day) for three weeks and then a combination of clofibrate (1.5 g/day) + ursodeoxycholic acid (0.75 g/day) for also three weeks. The serum concentrations of cholesterol, triglycerides and total bile acids as well as the biliary lipid composition (bile acids, phospholipids and cholesterol were assessed before the study, after the clofibrate therapy and after the combined treatment. Both therapeutic regimen lowered the serum cholesterol and triglyceride concentrations. The enhanced cholesterol saturation of bile during clofibrate treatment (lithogenic index of bile: 1.39; 0.73-1.40; median and range) was completely abolished by ursodeoxycholic acid (0.90; 0.62-1.27). It is suggested that this combination may be a useful way for the treatment of patients with hyperlipoproteinaemia.

Adult↗
PubMed1978

Use of constant target sets in visual search tasks.

54 subjects participated in a visual scanning study in which each subject was provided with only a single target set (of 1, 2, 4, 6, 8, or 10 letters in length). Eight sessions of 30 trials each were completed for each subject. Although there were slight differences in the rate at which performance improved over trials, this was not systematically related to size of target set. Moreover, even in the last session, there were large differences in performance in the different target sets. These findings suggest that Neisser's evidence for parallel preattentive processing in such tasks may have been confounded by his use of nested target sets and a within-subject design.

Adult↗
PubMedDate not supplied

[Preparation of a compatibility chart for intravenous drug therapy in neonatal and pediatric intensive care units].

BACKGROUND: Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand and on the other hand to avoid complications from incompatibilities of the administered drugs, we compiled a compatibility chart, encompassing more substances than covered in previously available charts. METHODS: Information on compatibility of commonly prescribed drugs was collected by analysis of manufacturers' information, medical and pharmaceutical handbooks, and a literature research. RESULTS: Available data on compatibility of 78 drugs were displayed in a two-dimensional chart. Beside the pH of each drug, compatibility of drug combinations was encoded for simultaneous infusion. Special emphasis was on security of the therapy. CONCLUSION: The compatibility chart gives quick reference for Data on compatibility of intravenously administered drugs in neonatal and pediatric intensive care.

Catheterization, Central Venous↗
PubMedDate not supplied

Posteruptive changes of electrical resistance values in fissure enamel of premolars.

In studies about 15-25% of the caries-free teeth proved to have as low electrical resistance values as carious teeth, due probably to incomplete enamel maturation. It was the aim of the present prospective clinical study to investigate, if an increase in electrical resistance values could be observed after the eruption of premolars. The electrical resistance measurements were performed in children who were patients of the Dental School of the University of Marburg, Germany. The first measurement was made when a premolar was erupting or when it had erupted within 12 months before. The electrical resistance measurements were repeated every 3-6 months until the 24th posteruptive month. The measuring device consisted of an AC ohmmeter modified by Gente indicating the real component of the impedance and employing a frequency of 500 Hz and an amplitude of about 1 microA. For erupting teeth a mean resistance value of 17+/-15 kohm was computed when the contact fluid had been NaCl (A). The corresponding values were 72+/-51 kohm when distilled water (B) had been applied and 392+/-374 kohm when the initially saliva-coated teeth had briefly been dried (C). The mean resistance values of the premolars increased continuously from the eruption up to the 15th posteruptive month. This observation was independent of the three modes of measuring that had been used. It is concluded that enamel maturation leads to an increase in electrical resistance. To improve accuracy of caries diagnosis with electrical resistance measurements, the posteruptive age of teeth should be taken into account. In addition, electrical resistance measurements offer the opportunity to observe enamel maturation in vivo noninvasively.

Adolescent↗