[Congenital myotonic dystrophy].
By means of a casuistic the set of problems in congenital myotonia dystrophica is demonstrated. Own results are discussed.
Adult↗
Biomedical subjects
A Schmidt
Publications and source records attributed to A Schmidt.
[Atherogenic implications in obesity and diabetes mellitus in children].
Explore the source record for details and available documents.
Age Factors↗
Predicting nurses' charting behavior based on Fishbein's model.
This study tested a theoretical model of behavior prediction within a quality assurance framework. Fishbein's mathematical model and the ANA quality assurance model were used to study nurses' charting behavior, based on selected attitudes, norms, and motivation levels. The sample consisted of nurses employed on a postcoronary care unit in a general, private hospital. Although significant findings were not obtained and the null hypotheses were not rejected, this study provided insight into nurses' attitudes, motivations, and behavior with regard to specific QA activities in a clinical setting.
Adult↗
[Extracorporeal lithotripsy and our future approach in lithiasis].
It can be claimed that ESWL is an optimal alternative for ablation of calculi by external shock waves. The new developments in ESWL focus more on the economic aspects of treatment rather than enhancing its efficacy or reducing the side effects. The routine indications of ESWL are well known and widely accepted. Similarly, its limitations are well defined: silent caliceal calculi, diverticular caliceal calculi, nephrolithiasis in horseshoe kidney, medullary sponge kidney and residual fragments after ESWL. Although endourology offers new, less invasive and less traumatic ways for stone ablation, such as lasertripsy, mini flexible ureteroscopes and ureteropyeloscopes, the indication for a more aggressive approach in the cases mentioned above is limited to the symptomatic cases. For calculi in the distal ureter, only the ureteroscope and intraureteral laser open new and interesting possibilities in the near future.
Animals↗
Identification of marker chromosomes by in situ hybridization technique using alpha and "classical" satellite DNA probes with relative chromosomal specificity.
Nine additional marker chromosomes in children with mental retardation and congenital malformation were investigated by routine cytogenetic and in situ hybridization techniques. Five metacentric non-satellited markers and four satellited markers of unknown origin were determined by routine and banding staining. To determine the origin of small marker chromosomes a special scheme involving the sequential application of definite alphoid and "classical" satellite DNA probes with the relative chromosome specificity was employed. The probes specific to four groups of definite chromosomes (i) 1, 3, 5, 6, 7, 10, 12, 16, 19; (ii) 2, 4, 8, 9, 13, 14, 15, 18, 20, 21, 22; (iii) 1, 11, 17, X; (iiii) 9, 13, 14, 15, 21, 22, Y and in situ hybridization under low stringency conditions were used at the first stage of experiments. After the preliminary analysis and the determination of possible origin of a marker chromosome from a definite group of chromosomes the probes with a strong chromosome-specificity under high stringency conditions were used. The approach involving the application of the original collection of chromosome-specific DNA probes, including molecular markers to practically all human chromosomes [1, 2], and various conditions of hybridization provides an effective method for detecting unknown markers. Marker chromosomes investigated in this study were derivatives of chromosomes 7, 9 (two cases), 13, 14, 21 (two cases), X and Y.
Chromosome Banding↗
[Doppler ultrasound studies of venous retrograde flow in precardiac veins of the fetus in normal and abnormal pregnancies].
Precardiac venous blood flow, umbilical artery and aortal blood flow of 120 unselected patients has been investigated by means of Doppler ultrasound. Measuring a hepatic vein directly before entering the inferior vena cava we found a characteristic blood flow pattern with a moderate foreward flow during systole and a small foreward flow during early diastole and a very small reverse flow because of atrial contraction during late diastole. We found changes in this flow pattern with reduction of the mean velocity in cases of high risk pregnancies with intrauterine growth retardation. Comparing normally developed fetuses with growth-retarded fetuses and vaginal delivery or caesarean sections without fetal distress with caesarean sections because of fetal distress we found significant differences with lower mean velocities in the precardiac veins of the latters. Comparing the precardiac venous flow velocities with the umbilical artery flow velocities and the fetal descending aortal flow velocities we found similar results of statistical values predicting growth retardation and caesarean section because of fetal distress. We concluded that venous Doppler flow velocity analysis is also able to predict perinatal risks like intrauterine growth retardation or caesarean section because of fetal distress as good as flow velocimetry of the umbilical artery or the fetal aorta; if it is impossible to demonstrate the fetal descending aorta or the vena cava inferior sonographically correctly the investigation of the hepatic vein may give you more reliable Doppler values for your clinical management.
Adult↗
Accuracy of implant impression techniques.
Three impression techniques were assessed for accuracy in a laboratory cast that simulated clinical practice. The first technique used autopolymerizing acrylic resin to splint the transfer copings. The second involved splinting of the transfer copings directly to an acrylic resin custom tray. In the third, only impression material was used to orient the transfer copings. The accuracy of stone casts with implant analogs was measured against a master framework. The fit of the framework on the casts was tested using strain gauges. The technique using acrylic resin to splint transfer copings in the impression material was significantly more accurate than the two other techniques. Stresses observed in the framework are described and discussed with suggestions to improve clinical and laboratory techniques.
Acrylic Resins↗
Glycosyl-phosphatidylinositols in protozoa structure, biosynthesis and intracellular localisation.
We are investigating the structure and biosynthesis of glycosyl-phosphatidylinositols (GPI) in the protozoa Toxoplasma gondii, Plasmodium falciparum, Plasmodium yoelii and Paramecium primaurelia. This comparison of structural and biosynthesis data should lead us to common and individual features of the GPI-biosynthesis and transport in different organisms.
Animals↗