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Biomedical subjects

A Schirger

Publications and source records attributed to A Schirger.

At least 37 records · Page 2Linked to original sources
PubMed1983

Lymphedema.

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Adolescent↗
PubMed1983

Pindolol--a new beta-adrenergic blocking agent with intrinsic sympathomimetic activity in the management of mild and moderate hypertension.

Pindolol, a well-tolerated noncardioselective beta-adrenergic blocking drug, effectively reduced blood pressure in patients with mild to moderate hypertension without causing orthostatic hypotension. In common with other beta-adrenergic blocking agents, pindolol blocked the normal increase in the standing pulse rate. The drug, however, did not decrease the supine pulse rate, a feature that can be interpreted as evidence of the postulated intrinsic sympathomimetic activity of pindolol.

Adolescent↗
PubMed1981

Midodrine. A new agent in the management of idiopathic orthostatic hypotension and Shy-Drager syndrome.

Five patients with idiopathic orthostatic hypotension, two of whom had central nervous system manifestations (Shy-Drager syndrome), were treated with midodrine, an investigational alpha-adrenergic agonist, in a dosage of 2.5 to 5 mg three times daily. Significant improvement was observed in the standing systolic and diastolic blood pressures at the end of 1 week of therapy in all patients and has been maintained for 10 to 15 months in all patients. No symptomatic side effects were noted. Supine systolic hypertension occurred in two patients and was treated with small doses of metoprolol.

Adult↗
PubMed1981

Orthostatic hypotension.

This article reviews the physiology and pathology of orthostatic blood pressure regulation. It describes the diverse clinical disorders of postural blood pressure adjustment, focusing attention on idiopathic orthostatic hypotension and the Shy-Drager syndrome, with emphasis on clinical aspects, pharmacology, and pathologic anatomy. Proposals are made for the diagnostic evaluation of patients with orthostatic hypotension and for steps to be taken in therapeutic management.

Adult↗
PubMed1977

Prazosin-new hypertensive agent. A double-blind crossover study in the treatment of hypertension.

Prazosin hydrochloride, a new antihypertensive agent, is said to be of mild-to-moderate potency when used as a sole agent in mild-to-moderate hypertension and when used in conjunction with other agents in severe hypertension. In our study of 14 patients comparing hydrochlorothiazide with prazosin, the antigypertensive effect of prazosin was less than that of hydrochlorothiazide. The greatest application of prazosin may be in conjunction with thiazide diuretics and beta-adrenergic blocking agents as the second or third drug.

Adrenergic beta-Antagonists↗
PubMed1977

Lymphedema: results of surgical treatment in 64 patients (1936-1964).

Patients with peripheral lymphedema are usually treated without operation. In some, however, operations are required in order to reduce swelling, ensure comfort, and improve function and appearance. Because new surgical approaches are available for the treatment of peripheral lymphedema, we reviewed our previous operative experiences for these conditions at the Mayo Clinic to provide a reference to which the newer procedures may be compared. Sixty-four patients underwent operation for peripheral lymphedema between 1936 and 1964. Follow-up information was obtained on 56 patients. Seventeen patients required three procedures to alleviate the swelling in an extremity. Morphologic aspects of the excised tissue were also evaluated in these cases. Results were considered excellent in 13, good in 22, fair in 8, and poor in 13. Complications of operation consisted primarily of wound infections, hematomas, and necrosis of skin flaps.

Adult↗