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Biomedical subjects

A Schilling

Publications and source records attributed to A Schilling.

At least 91 records · Page 5Linked to original sources
PubMed1989

[The dysuria syndrome. Significance of urethral diameter for recurrent bacterial cystitis in the female].

Internal urethrotomy is still used in female patients for the prophylactic treatment of recurrent bacterial cystitis as well as for sterile dysuric voiding disorders. 72% of the bacterial cystitis group (n = 18) remained uninfected during the 1st year after the treatment. 60% of the women with sterile dysuria complaints reported a significant improvement after the surgical procedure. The success is most possibly due to improved urodynamic conditions. The necessity of urethrotomy in patients with recurrent bacterial cystitis is discussed. The etiology of sterile dysuric voiding disorders however remains unclear.

Adult↗
PubMed1988

Pharmacokinetics of sulbactam and ampicillin intravenously applied in combination to healthy volunteers and patients. Determination of the ratio of the two drugs in serum and in various tissues.

The pharmacokinetics of sulbactam, a new beta-lactamase inhibitor, and ampicillin were investigated in 9 healthy volunteers and 125 patients. The two drugs were administered intravenously in combination (Unacid). Each subject received 1 g sulbactam and 2 g ampicillin. The two drugs showed a similar pharmacokinetic profile in humans. Relevant pharmacokinetic parameters were calculated using a 2-compartment model on the basis of the serum and urine concentrations determined in healthy volunteers. The ratio of sulbactam to ampicillin was found to be nearly constant (approx. 1:2), both in the blood, in several tissues and at various time points. The two compounds apparently penetrated well into the myometrium, renal cortex and medulla, the gall bladder wall, the tonsils and the cutis of the skin. The sulbactam/ampicillin ratios in the bile ranged from 1:3 to 1:13 over 2 h after the infusion. The concentrations of the two compounds measured in the various fluids and tissues of the body reached levels which are effective against beta-lactamase producing bacteria. The similar pharmacokinetics of sulbactam and ampicillin in humans are considered an essential prerequisite for the therapeutic efficacy of such a combination product.

Adult↗
PubMed1987

Coagulation factor XIII: genetic linkage studies with F13B.

Linkage relations of the F13B gene with 38 marker genes are analyzed, which, along with the data of earlier reports on the same subject, brings the number of comparisons to a total of 49. Practically all the lod scores are totally negative. This will mean that the F13B gene can hardly be located on the chromosomes/chromosome arms 1p, 2p, 4q, 6p, 14p, 15p, 20q, 21p, 22 and also not on longer segments of 3q, 6q, 7q, 9p, 9q, 11q, 13q, 14q, 16p, and 16q.

Child↗
PubMed1987

[Magnetic resonance tomography in ophthalmology. I. Choroid melanoma].

The value of magnetic resonance tomography (MRT) for the diagnosis of choroidal melanomas is illustrated with reference to 26 cases. The geometric dimensions of the tumors are in good agreement with findings obtained by ultrasonography. The relaxation time T2 varies between 85 and 120 msec in contrast to 145-210 msec in subretinal hemorrhages and 190-400 msec in secondary retinal detachments. In contrast to A-scan a differential diagnosis is possible even with lesions less than 1.5 mm in prominence. In solutions of melanin the relaxation time T2 decreases with increasing melanin concentration. This leads to an interpretation that the pigment content of the melanoma is responsible for the relatively short relaxation times. Thus, the relaxation time T2 is a useful factor in predicting metastasis.

Choroid↗
PubMed1987

Chemohormonal therapy in advanced carcinoma of the breast: Cancer and Leukemia Group B protocol 8081.

In a prospective, randomized trial Cancer and Leukemia Group B (CALGB) evaluated CAF chemotherapy (cyclophosphamide + doxorubicin + 5-fluorouracil [5-FU]) v CAF plus tamoxifen (TCAF) in advanced breast cancer. Patients were stratified by estrogen receptor (ER) status, dominant site of metastatic disease, menopausal status, and prior adjuvant therapy. Regardless of ER status or menopausal status, the addition of tamoxifen conferred no significant advantage in response rate, response duration, time to treatment failure (TTF) or survival over CAF alone. A secondary objective was to compare the response to CAF of ER positive (ER+) and ER negative (ER-) patients to determine if there was a differential response to cytotoxic chemotherapy. Response rates of ER+ and ER- patients to CAF were identical (56%), but the response duration, time to treatment failure, and survival of ER+ patients were significantly longer than ER- patients. This lack of differential response implies that chemotherapy and hormonal therapy may compete for the same pool of ER+ cells. It also suggests that chemotherapy kills breast cancer cells indiscriminately, regardless of ER status.

Adult↗
PubMed1987

Role of prolactin in a pheromone-like sexual inhibition in the male lesser mouse lemur.

Sexual activity of the male lesser mouse lemur can be induced by a long photoperiod, and plasma testosterone concentrations increase from 20 to 220 nmol/l within 3 weeks of photoperiodic stimulation. When isolated males were exposed to the volatile compounds from the urine of an active dominant male for 4 weeks at the beginning of the long daylight period, they demonstrated a significant decrease in testosterone concentrations (134 +/- 11 nmol/l) compared with controls (210 +/- 26 nmol/l) within 2 weeks. Lowering concentrations of prolactin by daily injections of bromocriptine prevented the decrease in testosterone in males simultaneously exposed to the odorant stimulation. Increasing concentrations of prolactin by daily injections of sulpiride mimicked the effect of the odorant stimulation in males receiving only fresh non-odorized air. The decrease in testosterone was strengthened when sulpiride was administered concurrently with exposure to urine. These results support the conclusion that variations in the concentration of prolactin are involved in the neuroendocrinological process mediating the pheromone-like sexual inhibition in the male lesser mouse lemur. However, daily injections of bromocriptine in males which were photoperiodically stimulated but not exposed to dominant male urine odour, also induced a significant decrease in testosterone concentrations. This finding suggests that two different systems involving prolactin and leading to opposite effects might be implicated in the regulation by environmental factors of sexual activity in the male lesser mouse lemur.

Animals↗
PubMed1986

Use of the neodymium-YAG laser in the treatment of ureteral tumors and urethral condylomata acuminata. Clinical experience.

The further development of endoscopic instruments has made neodymium-YAG laser irradiation of ureteral tumors possible. To date a total of 13 ureteral tumors in 10 patients have been photocoagulated. Over a mean follow-up period of 23 months, only 1 heterotopic recurrence was found after 14 months. In view of the results achieved so far, nephroureterectomy as the first therapeutic step appears to have been made obsolete. Since 1979 we have treated 48 patients with the neodymium-YAG laser. Seven patients with excessive condyloma involvement were followed postoperatively. Our experience indicates that, in view of its low complication and recurrence rates, endoscopic laser coagulation of urethral condylomata is the method of choice. A short-term ureteroscopic follow-up examination, however, is required to detect any condylomata that might have been overlooked.

Adult↗
PubMed1985

[Treatment of superficial ureteral tumors using the neodymium-YAG laser].

Today NYG laser radiation can be combined with ureteroscopy for endoscopic staging as well as the treatment of ureteral tumors. In a small series of 10 patients, 13 ureteral tumors were laser-irradiated. The mean follow-up was 23 months. Only one heterotopic tumor recurred after 14 months. Therefore, we feel carrying out nephroureterectomy as the first therapeutic step is unnecessary and should be avoided.

Aged↗
PubMed1984

[Nephrolithiasis--correlation of calculus type and pathogen spectrum. Calculus analysis and microbiologic diagnosis in 173 surgically treated patients].

The microbiological findings from intraoperative swabs were correlated with the consistency of the calculi in 173 patients, who had been operated on due to nephrolithiasis. The following parameters were taken into consideration: age and sex of the patients, consistency of calculi and germ spectrum of intraoperative swabs from the upper urinary tract. Three main groups were formed corresponding to the consistency of the calculi (carriers of infection calculi, of calciumoxalate calculi and of uric acid calculi) and these were compared to one another regarding the above mentioned parameters.

Bacteriological Techniques↗
PubMed1984

Sexual inhibition in a prosimian primate: a pheromone-like effect.

The effect of dominant urine odour on plasma levels of testosterone and cortisol was studied in the prosimian primate Microcebus murinus. This species shows a photoperiod-dependent cycle of sexual activity. In particular, mean testosterone levels vary from 15 nmol/l during the annual rest period to 245 nmol/l during the breeding season. When males of this solitary and territorial species are artificially grouped in captivity, they develop a social hierarchy which in turn results in physiological disorders, especially of reproductive function, in non-dominant individuals. Since olfactory behaviours appear to be important in the establishment and maintenance of the social structure, we have tested the effects of dominant odorant signals upon the sexual inhibition observed in male conspecifics. A preliminary experiment showed that a decrease in plasma testosterone concentrations could be induced by dominant scent marks. Furthermore, dominant urine odour alone was found to be sufficient to induce this modification. Plasma cortisol levels also increased in these animals. Conversely, when sexually inhibited males were olfactorily isolated from dominant urine odour, testosterone and cortisol concentrations returned to a normal seasonal level. These effects were observed even in males which had had no previous contact with the dominant urine donor. It is inferred from these results that a pheromone-like process could lead to sexual inhibition in male Microcebus murinus exposed to an odorant urinary signal produced by a dominant individual. Nevertheless, the endocrine response seems to vary according to the seasonal period of the sexual activity cycle which suggests that the social effect described is modulated by other external (e.g. photoperiodic) or internal (e.g. reproductive physiology) factors.

Animals↗
PubMed1984

[Therapy of acute radiation cystitis. A case report].

We report a patient with prostate cancer who suffered from severe radiation cystitis after combined interstitial radiation with 125-Iodine-Seeds and external radiation (2000 rad). This patient was treated very successfully with intramural injection of Orgotein (Peroxinorm) into the bladder wall. Besides discussion of the aetiology of radiation cystitis we report our first favourable results with local and systemic treatment with Orgotein (Peroxinorm).

Acute Disease↗
PubMed1984

[Urinary tract infections caused by hospital infections (nosocomial infections). A long-term study].

A computerized analysis of hospital acquired urinary tract infections from 1973-1976 as well as 1981-1982 was done at our institution. A change in the classic picture of "gramnegative infections" was observed. Grampositive germs such as enterococci and staphylococci increased in their significance. The incidence of bacteremia and sepsis was lowered. This success is due to strict antiseptic measures as well as to the more frequent use of the suprapubic puncture catheter instead of the transurethral catheter.

Aged↗
PubMed1983

[Inhibition of the renin-angiotensin system in the ischemic kidney].

By blocking the renin-angiotensin-system with saralasin or salt-loading the postischemic damage of the renal microcirculation is diminished. This can be realized in a markedly improved oxygenation of renal tissue. As a result of the improved microcirculation 60 minutes after a 120-minutes ischemic damage one can find a better filtration rate, i.e. tubular function in treated kidneys.

Aminohippuric Acids↗
PubMed1983

[Microsurgical penis replantation following self mutilation].

Although amputation of the penis is a rare problem, a complete reconstruction of all penile structures should be attempted in one stage. This way the best chance for full rehabilitation of the patient can be achieved. A microsurgical reimplantation with microsurgical sutures of arteries, veins, nerves and urethra after total amputation of the penis is reported. Eight months after surgery normal appearance and function, including a good urine flow and absence of urethral stricture, capability of erection and nearly normal sensitivity, was found.

Humans↗