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Biomedical subjects

A Scheinin

Publications and source records attributed to A Scheinin.

At least 19 recordsLinked to original sources
PubMed1996

Assessment of single risk indicators in relation to caries increment in adolescents.

Base-line data on a series of risk indicators were related to 11-month caries increment in 181 subjects with a mean age of 13 years and 3 months. A caries increment equalling or exceeding one tooth surface was recorded in 21% of the subjects. The risk indicators consisted of past caries experience, white spot lesions, visible plaque and gingivitis, and six salivary tests: secretion rate, buffer effect, sucrase, mutans streptococci, lactobacilli, and Candida. Significant associations between caries increment and past caries experience (p = 0.002), white spot lesions (p = 0.01), lactobacilli (p = 0.02), Candida (p = 0.006), and sucrase (p = 0.02) were observed. The ensuing odds ratios were thus recorded: past caries experience, 3.6; white spot lesions, 2.9; salivary sucrase activity, 2.9; lactobacilli, 2.5; and Candida, 2.8.

Adolescent↗
PubMed1996

Multifactorial modeling for prediction of caries increment in adolescents.

The purpose of the study was to develop a multifactorial model for the prediction of 11-month caries increment in adolescents. The mean age of the subjects (n = 181) at the base-line examination was 13 years and 3 months. The risk indicators consisted of past caries experience, white spot lesions, visible plaque, gingivitis, salivary secretion rate, buffer effect, sucrase, mutans streptococci, lactobacilli, and Candida. The multifactorial modeling included all the above risk indicators, age, and gender and resulted in different models in boys and girls, indicating the difficulty of caries prediction in adolescents. When boys and girls were combined, the final model included past caries experience, Candida, and salivary sucrase. Although the accuracy of the model was slightly below the 80% level recommended for screening purposes, the results provide clinically valuable information. The risk of caries increases with an increasing number of positive tests within the model.

Adolescent↗
PubMed1994

Multifactorial modeling for root caries prediction: 3-year follow-up results.

The study was part of a series aiming at the development of caries tests. The initial material (n = 104, age range 47-79 yr, mean 62 yr) was reduced to 96, who were observed for 3 yr. During the follow-up four subjects died, all due to myocardial infarction, and four refused to participate. Thorough oral examinations were conducted at the baseline, 1- and 3-yr registrations; coronal and root surface caries were registered separately according to WHO classification. The tests included salivary mutans streptococci, lactobacilli, candida/yeasts, secretion rate, buffer effect and sucrase activity, and quantitation of visible plaque. The association between prospective root caries increment and several tests was significant. Multifactorial modeling resulted in the combination of Past Root Caries Experience (OR 12.8), Lactobacilli (OR 8.6) and Candida (OR 2.8). At screening, the criterion "two or three positive tests" of these yielded acceptable accuracy (77.1) and a relative risk of 3.3.

Aged↗
PubMed1993

Xylitol-induced changes of enamel microhardness paralleled by microradiographic observations.

The study, aimed to analyze the feasibility of a prospective field study, was carried out in Polynesian children with rampant untreated caries. Slabs of bovine enamel were inserted for 8-12 days in cavities and subsequently replaced by permanent fillings. Before use, the surface of the slab was polished, and one half predemineralized and tested for microhardness. The follow-up in 30 subjects involved 54 slabs, 30 from negative controls with no added sweets and 24 from subjects receiving 20 g/day of xylitol in candy. The microhardness of the slabs was reassessed, and the difference between measurements calculated and tested for significance. The differences between the groups were highly significant, the predemineralized halves showing pronounced rehardening at exposure to xylitol. Parallel microradiographic observations conformed with the above findings. The results indicate that the use of a noncariogenic sweetener might be of value in high caries risk subjects.

Animals↗
PubMed1992

Multifactorial modeling for root caries prediction.

The study was part of a series of investigations aiming at the development of diagnostic caries tests for screening of risk subjects. The material consisted of 100 adult subjects (mean 62 yr, range 47-79 yr), 50 of these under chronic medication. The series of tests included two chairside registrations, i.e. incipient demineralization of exposed root surfaces without cavitation (RD 1) and quantitation of visible plaque (VPT%), three microbiological tests for mutans streptococci, lactobacilli, and candida/yeasts and three tests on stimulated saliva, i.e. secretion rate, buffering capacity and sucrase activity. A thorough clinical examination was conducted at the baseline and 1-yr registration phases, caries being registered at a tooth surface level according to WHO recommendations separately for coronal and root caries. Considerably more root caries than coronal caries developed during the observation period. For coronal caries increment, the predictive value of any of the tests was not significant. For root caries, however, the association between several tests and prospective caries increment was significant. Subsequent multifactorial modeling yielded the highest predictive value to the combination of Past Root Caries Experience (OR 25.0, Visible Plaque (OR 4.2), Candida (OR 8.0) and Lactobacilli (OR 5.8). A positive finding of Past Root Caries (RDFS) or the combination of the other three tests (Can, LB, VPT%) as criteria for selection in screening for root caries produced good accuracy (84.0) and a relative risk of 5.5.

Aged↗
PubMed1992

[The assessment of the caries risk in young adults].

Several factors for caries prediction have been proved in a one-year follow-up study on 73 patients. The white-spot lesions have proved to be a good criteria for caries prediction in this population. These lesions could be combined with the microbiological tests Dentocult SM and Oricult N or with the determination of the buffer capacity (Dentobuff), which did not much improve the prediction.

Adult↗
PubMed1991

Perspectives on xylitol-induced oral effects.

The review covered xylitol-induced effects on oral health. Xylitol was considered virtually nonacidogenic and to possess specific and unspecific advantageous effects on oral health. It was shown to mediate nonspecific remineralization, while its demineralization-inhibiting and S. mutans-reducing effects were regarded as specific. The clinical trials and field studies indicated that partial substitution of dietary sucrose by low doses of xylitol was associated with a pronounced caries reduction.

Cariostatic Agents↗
PubMed1989

Sucrose consumption and salivary sucrase activity in a 2-year longitudinal study.

Sucrose consumption data of the sucrose group (n = 33) of a 2-yr longitudinal study was plotted against salivary sucrase activity values obtained during this 2-yr period. The correlation coefficients varied between 0.194 and 0.551. The subjects were divided into high (greater than or equal to 10 mumol x min-1 x (10(-3)) and low (less than 10) sucrase activity subgroups. There were significant differences in the sucrose consumption and in intake frequency between these two subgroups. These findings give further support for the possibility of using sucrase activity for the estimation of the level of individual sugar consumption.

Adult↗
PubMed1987

Screening of caries in children through salivary lactobacilli and yeasts.

The caries predictive value of salivary counts of lactobacilli and yeasts was evaluated in 298 children (from 6 to 11 yr of age) concurrently to a 3-yr xylitol field study in Hungary. On a group level the salivary yeasts and the combined information of lactobacilli and yeasts predicted the 3-yr caries increment acceptably. On an individual basis salivary yeasts had more power than salivary lactobacilli. At best the sensitivity and specificity of yeasts were 74% and 75%, and the combined information of lactobacilli and yeasts, 69% and 83%, respectively. Although the results were not that good in all subgroups of the study, they indicate the value of salivary yeasts in caries prediction either as a sole test or together with salivary lactobacilli.

Child↗