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Biomedical subjects

A Schauer

Publications and source records attributed to A Schauer.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

[Scanning electron microscopy and elementary analytic studies of osteosarcoma].

By scanning electron microscopical (SEM) screening analyses of 14 osteosarcomas characteristic three-dimensional structures of tumor osteoid could be demonstrated. These osteoid formations are highly characteristic for osteosarcoma; we did not find them at any other bone tumor or tumor like lesion until now. With these results a better understanding of characteristic growth patterns of bone tumors could be achieved by SEM. No specific results could be found by elementar analysis, x-ray microanalysis, x-ray fluorescence and x-ray diffractometer techniques. The significance of single interesting values has to be evaluated in the future.

Bone Neoplasms↗
PubMedDate not supplied

Cystosarcoma phyllodes of the breast: prognostic significance of proliferation and apoptosis associated genes.

BACKGROUND: Cystosarcoma phyllodes (CP) is a rare fibroepithelial tumor of the breast. So far no valuable prognostic factors are available for predicting the biological behaviour and often unexpected clinical outcome of this tumor. PATIENTS AND METHODS: Using immuno-histochemistry, Mib-1 evaluated proliferative activity and expression of p53, Bcl-2, c-erbB1, c-erbB2, cytokeratin and vimentin were analysed in 17 benign and 12 malignant CP. RESULTS: Cell proliferation was significantly higher in malignant tumors compared to benign ones both in the epithelial and mesenchymal parts. In the epithelial part Bcl-2 positive cells were found more frequently in benign than in malignant lesions. Positive immunoreactivity for p53 was seen in only one malignant case. The reaction was positive in the both epithelial and mesenchymal compartments. Expression of c-erbB-proteins was not found in any case. The intermediate filament proteins indicate clearly the two components of the tumor. CONCLUSIONS: We concluded that increased proliferate activity and downregulation of Bcl-2 may be associated with dedifferentiation of cells and malignant progression. C-erbB-proteins are obviously not involved in carcinogenesis of CP.

Apoptosis↗