Search PubMed⌕ Search

Biomedical subjects

A Sawada

Publications and source records attributed to A Sawada.

At least 109 records · Page 6Linked to original sources
PubMed1992

[A case report of bone metastasis diagnosed by MRI and effectively treated with UFT after breast conserving therapy for breast cancer].

A 66-year-old woman with left breast cancer (medullary carcinoma; T1cN1M0; Stage II A) was treated with breast conserving therapy combined with lumpectomy, radiotherapy, chemotherapy and endocrine therapy beginning in March, 1990. She complained of back pain and was diagnosed as having bone metastasis to the lower thoracic spine by bone scintigram and MRI examination in September, 1990. Oral administration of UFT (300 mg/day) was started, and 5 months later, back pain disappeared; nineteen months later, no definite findings of bone metastasis were observed on bone scintigram and MRI. It was concluded that long-term oral administration of UFT is an effective remedy for bone metastasis after breast conserving therapy for breast cancer.

Administration, Oral↗
PubMed1992

[Effect of metoclopramide, dopamine receptor blocker, on the EOG light peak].

We studied the effects of metoclopramide hydrochloride (MTCL), a D2-selective dopamine receptor antagonist, on the electro-oculograms (EOGs) in 10 eyes of 5 healthy volunteers and on the electroretinograms (ERGs) in 6 eyes of 3 volunteers. MTCL was given intravenously after 15 minutes of dark adaptation. The L/D ratio of EOG was 2.13 +/- 0.14 (mean +/- SE) before the administration of MTCL. After the administration of MTCL, the dark-adapted EOG amplitudes increased transiently. MTCL significantly depressed the L/D ratio to 1.60 +/- 0.07 (p less than 0.01). The a- and b-wave amplitudes of the flash ERG decreased by 12% and 11% respectively. However, the OP2 and OP3 amplitudes of oscillatory potential increased by 23% and 19% respectively. The implicit times of all waves mentioned above tended to be prolonged. This study shows that a blockade of D2-dopamine receptor supresses the EOG light peak. Further investigations are needed to clarify the exact mechanism of this effect.

Adult↗
PubMed1990

Atypical nerve fiber layer defects in high myopes with high-tension glaucoma.

The incidence of atypical optic nerve head and retinal nerve fiber layer defects was studied in 61 high myopic eyes (greater than or equal to -5 diopters) and 91 emmetropic or hyperopic eyes (0 to +3 diopters) of 152 patients with chronic high-tension glaucoma, and in 45 control myopic eyes (greater than or equal to -5 diopters). Horizontal ovalness or cyclotorsion, oblique insertion of the optic disc, and bean pot disc were more common in the high myopes. In the eyes with high myopia with glaucoma, inferior dominant nerve fiber layer defects, ectopic fiber defects, and multiple nerve fiber layer defects were common. The incidence of superior nerve fiber layer defects or superior-inferior equal nerve fiber layer defects was high in round or vertically oval discs and low in cyclotorted or horizontal oval discs. The oblique insertion of the discs correlated positively with a higher incidence of ectopic defects in high myopic eyes with glaucoma. The incidence of focal type nerve defects is higher in older patients and high myopes with oblique insertion of the optic disc. Atypical shape of the optic disc correlates positively with atypical retinal nerve fiber layer defects in eyes with high-tension glaucoma.

Adolescent↗
PubMed1990

Clinical studies on the occurrence and the pathogenesis of optociliary veins.

We reviewed retrospectively 20 cases of optociliary vein over the past 5 years. Fifteen of the 20 cases (75%) were over 40 years of age. There was no sex differences (9 males and 11 females). Causative ocular diseases were: central retinal vein occlusion (14 cases, 70%); optic disc drusen (2 cases, 10%); and optic nerve sheath meningioma, high myopia, glaucoma, congenital anomaly (1 case each, total 20%). The number of patients with an optociliary vein was high in central retinal vein occlusion (14/190 cases, 7.4%). We concluded that occurrence of optociliary vein is not restricted to cases with optic nerve sheath meningioma and this shunt vessel may occur under other conditions in which central retinal venous return is seriously disturbed. The most common cause of optociliary vein is central retinal vein occlusion.

Adolescent↗
PubMed1990

Characterization of magnesium dependent adenosine 5'-triphosphatase in bovine brain cytoplasmic dynein.

The Mg2(+)-ATPase activity of cytoplasmic dynein isolated from bovine brain was examined in the absence of microtubules. Cytoplasmic dynein in the absence of microtubules showed Mg2(+)-ATPase activity with two distinct Km values, 272 microM and 11.8 microM. The initial burst of Pi liberation, which was due to occurrence of slow decomposition of reaction intermediate, was 0.67 mol per mol of cytoplasmic dynein. These results indicate that Mg2(+)-ATPase reaction of cytoplasmic dynein in the absence of microtubules is similar to that of flagellar and ciliary dyneins which have been shown not to hydrolyze ATP via a single pathway.

Animals↗
PubMed1989

Axonal transport in mdx mouse sciatic nerve.

Anterograde and retrograde flows of acetylcholinesterase (AChE) in sciatic nerves of adult mdx mice were compared with those of normal mice. Specific molecular forms of AChE were resolved by high-performance liquid chromatography such that slow anterograde (G1 + G2), fast anterograde and fast retrograde (G4 and A12) flows could be simultaneously studied. Although we found no difference in the total AChE activity and the molecular forms in non-ligated nerves between mdx and the normal mice, ligated nerves showed significant differences. The total AChE activity accumulated at the proximal segment of ligated nerve was higher in mdx mice than in normal mice after 24 h ligation. The G1 + G2 molecular forms were accumulated more in the proximal segment of mdx than the normal. A12, on the other hand, was more abundant in both segments of mdx mice than the normal. No statistically significant difference in the accumulated amount of G4 molecular form was present between mdx and the normal mice at either proximal or distal segment. These results indicated that axonal flow in sciatic nerve likely plays a role in muscle regeneration, and that the transport machinery in dystrophin-deficient mdx neuron is probably normal.

Acetylcholinesterase↗
PubMed1989

[Relationship of TMJ sounds and mandibular movements].

TMJ sounds are very important for diagnosing the state of TMJ and for evaluation of the effect of treatment. We made a report on a recording system of TMJ sounds and mandibular movement which objectively can evaluate the relationship between TMJ sounds and mandibular movement. This time we recorded and analyzed the TMJ sounds and mandibular movement under following condition. 1. Opening and closing the mandibular on some regulated velocity. 2. Opening and closing the mandibular after clenching. Conclusion 1. In case of changing habitual opening velocity, there were significantly different position of clicking in the most of TMJ disorders patients. Especially with the increasing of the velocity, the position of closing clicking tended to come near the closed condyle position. 2. The amplitude of clicking sound increased very much at the time of opening stage after clenching on the non clicking side.

Bite Force↗