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Biomedical subjects

A Savarese

Publications and source records attributed to A Savarese.

29 records · Page 2Linked to original sources
PubMedDate not supplied

Vancomycin prophylaxis in joint arthroplasty.

Postoperative infections in prosthetic surgery still constitute a serious problem, and one that is difficult to treat, because of the occurrence of agglomerates of microbes that are resistant to immune defenses and antibiotics. In nearly all cases, removal of the prosthesis is the only possible means of solving the problem of infection. The systematic use of antibiotic prophylaxis in surgery of this sort offers advantages in terms of a reduction in the risk of infection. The authors present a personal case series relative to the strategies of perioperative antibiotic prophylaxis used in cases of hip and knee arthroplasty; we refer to 233 joint arthroplasties performed between October 1993 and April 1996. In all of the cases, perioperative prophylaxis with vancomycin chlorohydrate at a dose of 1 g i.v. 1 hour prior to surgery, and 6-8 hours after surgery was carried out. The choice of the antibiotic was based on the epidemiological knowledge of the literature and the experience on the ward.

Aged↗
PubMedDate not supplied

Traumatic dislocations of the patella: problems related to treatment.

Traumatic dislocation of the patella is an infrequent occurrence favored by dysplasia of the extensor apparatus of the knee. The problem of diagnosis is at the basis of a choice of treatment, as any pre-existing dysplasia may be worsened by traumatic dislocation. Furthermore, the presence of a patellar or femoral osteochondral fragment, a more frequent finding than is generally believed as demonstrated by arthroscopy, influences surgical treatment. The results of 37 cases are reported, and several details related to surgical method discussed.

Adolescent↗
PubMedDate not supplied

Breast cancer heterogeneity assessed by flow cytometry.

The natural history of breast cancer is characterized by a marked heterogeneity within and between patients. During the clinical phase, there is ample opportunity for clonal mutation and evolution, and it seems probable that almost all breast cancer patients have multiple tumor clones, each with its own growth requirements, growth rate, ability to metastasize and sensitivity to drugs. Flow cytometry (FCM) is a technique which can rapidly and quantitatively measure a wide variety of cellular features. This can explain its large employment in the development and validation of tumor markers for prognostic and therapeutic purposes. The study of DNA content and cell cycle represents the most common application of FCM on solid tumor analysis. The use of monoclonal antibodies raised against functional and phenotypic cell markers can improve the suitability of FCM to assess the prognostic significance of these parameters; at the same time it could provide a helpful tool for a combined investigation of differentiation, proliferation and aggressiveness tumor markers, and their clinical relevance.

Breast Neoplasms↗