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Biomedical subjects

A Sari

Publications and source records attributed to A Sari.

At least 37 records · Page 2Linked to original sources
PubMed2001

Multiple congenital epulis of the alveolar ridge and tongue.

Congenital granular cell tumor, also known as congenital epulis, is a very rare lesion seen in newborns. The typical presentation is a solitary nodule occurring on the gingiva of the anterior alveolar ridge of either jaw. Multiple-site involvement is seen very seldom but has been noted on the same or different alveolar ridges. However, tongue involvement is exceptional, and there have been only three cases reported involving both the alveolus and the tongue. A female newborn with multiple congenital epulis on the mandibular alveolar ridge and tongue is presented, and her preferred treatment and histopathological diagnosis are discussed.

Alveolar Process↗
PubMed2001

Cerebriform fibrous proliferation vs. proteus syndrome.

Proteus syndrome is a rare, congenital hamartomatous syndrome that presents with a wide range of abnormalities. Regardless of different manifestations found in different patients, there exists three mandatory criteria for the diagnosis of this syndrome: a mosaic distribution of the lesions, a progressive course, and sporadic occurrence. When these criteria are met, the presence of additional connective tissue nevi, which are encountered mostly on the plantar surface of the feet, suffices for the diagnosis of Proteus syndrome. The authors present a 48-year-old woman who had been evaluated for a lesion on the plantar aspect of her left foot that was diagnosed as keloid and was treated unsuccessfully. In the light of the literature and with the help of histopathological reevaluation, the authors thought this unique lesion may be a localized form of Proteus syndrome.

Diagnosis, Differential↗
PubMed2001

Histopathological changes of chorda tympani in chronic otitis media.

OBJECTIVE: To investigate whether histopathological changes of chorda tympani might exist in patients with chronic otitis media without facial paralysis. STUDY DESIGN: The study was designed as a prospective trial. METHODS: Twenty of 107 patients with chronic otitis media, in whom the chorda tympani were injured inadvertently during middle ear surgery, were enrolled into the study. The cases were divided into two groups based on the activity of chronic infection at the time of surgery. Twelve cases with suppurative disease were included in group I, and 8 cases with dry ear in group II. RESULTS: Histopathological examinations of the specimens revealed findings such as thickening of perineural and epineural connective tissue, vacuolar degeneration of Schwann cells, and proliferation of fibroblasts in endoneurium. Disorganization of the axons of some nerve fibers was also determined. CONCLUSION: Based on the histopathological changes of chorda tympani in chronic middle ear disease, it is postulated that chronic otitis media may give rise to functional loss of the nerve.

Adult↗
PubMed2001

Megacystis secondary to myenteric plexus pathology. Presentation of two cases.

Herein, 2 cases of megacystis secondary to myenteric plexus pathology are reported. Unlike the entity of visceral myopathy, there was ganglion cell loss both in the bladder and in the colon of these 2 cases. Moreover, they did not present any gastrointestinal symptoms. Megacystis was the common pathology in these patients, whereas 1 of them suffered from unilateral vesicoureteral reflux. We could not find any similar report dealing with this phenomenon up to this time in the literature.

Adolescent↗
PubMed2001

Chondrosarcoma of the thyroid cartilage.

Sarcomas of the larynx are extremely rare neoplasms that account for approximately one per cent of all tumours of this organ. We present a case of laryngeal chondrosarcoma originating from thyroid cartilage, characterized by an unusual long clinical course over 15 years without laryngeal symptoms or duplication of metastases, treated at the Süleyman Demirel University Medical Faculty, Ear, Nose and Throat (ENT) department.

Aged↗
PubMed2001

Electrophysiological effects of corticosteroids on the retinal pigment epithelium.

PURPOSE: As corticosteroids appear to intervene in pathogenesis of central serous chorioretinopathy, ion transport changes within the retinal pigment epithelium (RPE) might be involved. Electrophysiological responses to corticosteroid administration were recorded in vivo and in vitro. METHODS: Clinical study: The standing ocular potential was recorded during intravenous (IV) infusion of glucose 5% and glucose 5% + prednisolone 0.2% in 14 patients with relapsing multiple sclerosis. The results were compared with a control group receiving two successive identical glucose 5% infusions. In vitro study: Native tissue explants (RPE + choroid, porcine, and bovine) were placed in a Ussing-type chamber. After baseline determination of the transepithelial potential (PD), short circuit current (I(sc)) and transepithelial resistance (R(t)), the effect of apical hydrocortisone (HC) 10(-4) M was determined. RESULTS: Clinical study: A significant rise of the standing potential was found after glucose infusion (P = 0.005), whereas no change was detected after IV glucose + prednisolone (P = 0.695). In vitro study: In the porcine RPE, the mean baseline PD and I(sc) were significantly reduced (both P: = 0.012) after applying apical 10(-4) HC. R(t) was also significantly reduced (P = 0.01). The same type of response, observed in bovine RPE, was reduced in low chloride/low bicarbonate conditions. CONCLUSIONS: Corticosteroids modified electrophysiological parameters representing RPE function in vivo. The existence of an RPE-specific effect was confirmed in vitro. Further work is required to link the observed ion transport changes to a reduction of apical, subretinal fluid absorption.

Animals↗
PubMed2001

Marfan's syndrome, dextrocardia and situs inversus associated with discrete subaortic stenosis and aortic insufficiency in an adult female: case report.

Marfan's syndrome is an inherited connective tissue defect that affects many organs, especially of the musculoskeletal, ophthalmic and cardiovascular systems, and may be associated with some rare conditions. Here, we report the first known case of Marfan's syndrome, combined with situs inversus totalis with dextrocardia and discrete subaortic stenosis and aortic insufficiency in a 22-year-old woman.

Adult↗
PubMed2000

Milia en plaque.

Milia en plaque is a rarely reported entity which is usually appearing in the auricular region. We describe a well-defined, U-shaped milia en plaque arising in the infraorbital area, and emphasize that it should be considered in the differential diagnosis of xanthalesma.

Facial Dermatoses↗
PubMed2000

[Continuous monitoring to detect brain ischemia during carotid endarterectomy and aortic arch replacement by near infrared spectrophotometory--a case report].

We report two cases in which continuous monitoring was used to detect brain ischemia by 8-channel electroencephalograph (EEG), transcranial Doppler (TCD) of middle cerebral blood flow velocities and near infrared spectrophotometric monitoring (NIR) of bifrontal area simultaneously. The symptom of brain ischemia was indicated by NIR and TCD but not by EEG following temporary cross-clamping of the common carotid artery during carotid endarterectomy. According to this sign we successfully used temporary shunt during CEA. On the other hand, these methods of monitoring did not show abnormal findings of cerebral blood flow disorders during aortic arch replacement. Nevertheless, neurologic disorders were complicated postoperatively. In conclusion, these methods monitor carotid artery blood flow but not vertebral artery blood flow.

Aged↗
PubMed2000

Cerebellar atrophy following acute phenytoin intoxication.

A 25-year-old woman was admitted to our hospital with encephalopathy and clinical signs of cerebellar dysfunction. She had recently received an overdose of phenytoin. On admission, plasma phenytoin level was high (50 microg/ml, therapeutic range 10-20 mg/ml). Magnetic resonance imaging showed no signs of cerebellar atrophy. The patient's neurological condition improved rapidly after withdrawal of phenytoin. Eight months later, the neurological examination disclosed minimal cerebellar disorders and magnetic resonance imaging showed cerebellar atrophy. Cerebellar atrophy due to acute phenytoin intoxication is very unusual but few cases have been reported. The present clinical and radiological findings suggest that short-term phenytoin overdose alone may cause cerebellar atrophy.

Acute Disease↗
PubMed2000

The effect of GM-CSF (granulocyte macrophage colony stimulating factor) on doxorubicin induced tissue necrosis and wound healing.

PURPOSE: The effect of GM-CSF (granulocyte macrophage-colony stimulating factor) on tissue necrosis and ulceration induced with doxorubicin extravasation was studied. MATERIALS AND METHODS: Adult Wistar-Albino rats (n=36) were used in the study. Doxorubicin (0.4mg/300 g) was applied subcutaneously to abdominal wall. In group I (n=18), half hours after doxorubicin injection, GM-CSF 6 microg/300 mg was applied subcutaneously to the same localization. In group II (n = 18) same amount of physiologic saline (0.5 ml) were given subcutaneously to the injection site (as vehicle control groups). Group II and I were examined for induration or ulceration on 7th and 21st day. After evaluating the lesions, the injection sites were excised. Hydroxyproline (5-HP) values of dry tissue samples were calculated and histopathologic examination was done. RESULTS: At day seven there were four and eight ulceration in groups I and II, while there were four and 14 ulceration in the second evaluation at day 21st (p<0.05). 5-HP values of the groups were as follows. 97.43+/-20.39 in group land 91.34+/-22.26 in group II. Although there was an increase in epithelization, eosinophil and lymphocyte infiltration and mast cell number in group I in histopathologic examinations only the increase in angiogenesis in group I was found to be statistically significant (p<0.05). CONCLUSION: It can be concluded that GM-CSF may have beneficial effect in the treatment of doxorubicin induced tissue necrosis.

Animals↗