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Biomedical subjects

A Salem

Publications and source records attributed to A Salem.

At least 55 records · Page 3Linked to original sources
PubMed1988

Bithionol (Bitin) treatment in established fascioliasis in Egyptians.

The present study is an evaluation of bithionol treatment in established fascioliasis. Eight patients were enrolled in the study. All were passing eggs of Fasciola spp. and seven had concomitant Schistosoma mansoni infection. The clinical and haematological findings conformed with the known picture of fascioliasis. Bitin tablets (200 mg) were administered in the dose of 30 mg kg-1 body wt every other day for five doses. Eggs were counted during and for 4 months after the end of therapy. Fasciola ova disappeared after the second or third dose giving a cure rate of 100%. Ova of S. mansoni did not show any change in number. As regards the liver function tests; bilirubin, SGOT and SGPT values were within the normal range and were not affected by treatment. A raised SAP level was observed before therapy which was significantly higher after bithionol. Creatinine phosphokinase and lactate dehydrogenase enzymes and kidney function tests showed almost normal values and were not altered by therapy. It was concluded that Bitin was a potent fasciolicidal drug in the dose used. No side effects were observed.

Adolescent↗
PubMed1987

Homozygous sickle cell disease and priapism in the eastern province of Saudi Arabia.

Two adult sickle cell homozygotes from the eastern oases of the Kingdom of Saudi Arabia presented with severe persistent priapism. Each patient had a high Hb F of 24%, and their red cells were neither hypochromic nor microcytic. Priapism probably occurs more frequently in homozygous sickle cell disease than reported previously from this region. It would appear that a high fetal haemoglobin alone without hypochromia and microcytosis--features suggestive of co-existing alpha-thalassaemia--does not protect against this agonizing vaso-occlusive event.

Adult↗
PubMed1986

A short note on praziquantel in human fascioliasis.

Ten patients suffering from fascioliasis were treated with praziquantel. In two patients, egg counts dropped to zero following treatment, but there was no significant reduction in egg counts in the other eight.

Drug Administration Schedule↗
PubMed1984

The in-vitro activity of metronidazole against strains of Escherichia coli with impaired DNA repair systems.

The minimal inhibitory concentration (MIC) of metronidazole was lower for strains of Escherichia coli with lesions in their DNA repair systems than for their parent strains. The viable numbers of all strains of E. coli tested were considerably reduced by metronidazole, even at sub-MIC levels, and the effect was greater when DNA repair lesions were more severe. In addition, metronidazole caused cell elongation of E. coli and slowly disappeared from the medium upon incubation with the bacterium. The drug-induced decrease in viable numbers of E. coli was followed by an increase. Most cells in this 'recovery' population were found to be anaerogenic and were relatively unaffected by subsequent exposure to metronidazole. The results show that E. coli consumes and is susceptible to metronidazole, under anaerobic conditions. DNA damage is involved in the antibacterial action of the drug, and E. coli resistant to the drug can be obtained readily in in-vitro incubations.

DNA Repair↗
PubMed1982

The efficiency of various solvents in the extraction of chemical mutagens from living tissues: a comparative study.

The aim of this study is to find out the best solvent to be used in extraction of chemical pollutants from living organisms. Ethanol, benzene, chloroform, pentane, 1,4-dioxan, acetone, cyclohexane and ether were used in extraction of shrimp and clam samples collected from a Fahaheel site. The tissue extracts were tested for their mutagenic activity using E. coli and Salmonella on tester strains. The results revealed that ethanol was more efficient than other solvent in extraction of chemical mutagens concentrated in clams and shrimps.

Animals↗
PubMed1981

Lichen myxedematosus: histochemical study.

The case is reported of a diabetic female aged 32 years with lichen myxedematosus. Skin biopsy showed enormous amounts of mast cells (59,000/mm3) and heavy deposition of acid mucopolysaccharides.

Adult↗
PubMed1980

Metabolic changes in the serum of partially hepatectomized rats.

The factor(s) which trigger the proliferation of liver cells after partial hepatectomy in rats are not yet known with certainty. A series of specific and/or non-specific substances are said to effect the proliferation of liver cells, but metabolic changes after partial hepatectomy possibly also act as a contributory causative factor in the stimulation of those substances. In order to define this question more clearly the changes in the serum concentrations of the following metabolites in the course of time after partial hepatectomy were determined: free fatty acids, cholesterol, triglycerides, glucose, free amino acids and total protein. A reduction in the serum concentrations of some fatty acids and of glucose, and an increase in that of the free amino acids, was observed shortly after partial hepatectomy. The increase in the plasma concentration of immunoreactive glucagon after partial hepatectomy is thus explained and appears not to be of decisive significance for the stimulation of liver cell proliferation after partial hepatectomy.

Amino Acids↗
PubMed1975

[Determination of the closing volume and its value in the early detection of chronic obstructive lung disease].

The determination of the closing volume appears as a good test for the early detection of obstructive lung diseases and of disorders in the ventilation distribution. Easy to perform, its use should become extensive. To make use of this investigation under the better possible conditions, it is strictly necessary to respect methodologic norms and an excellent technology and to be aware of some morphologic anomalies in the curves.

Age Factors↗