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Biomedical subjects

A Salamy

Publications and source records attributed to A Salamy.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Scalp-recorded frequency-following responses in neonates.

Low-frequency tone bursts (250, 500 and 1 000 Hz) were used to elicit frequency-following responses (FFRs) from full-term, healthy neonates. Easily identifiable FFRs were recorded from all well babies with stimulation at low-to-moderate levels (30-45 dB HLn). The amplitude and threshold values of neonatal FFRs were not significantly different from those of normally hearing adults. As in the adult, neonatal FFRs elicited by tone burst stimuli of 250 and 500 Hz were of greater amplitude and were observed at lower stimulus levels than FFRs recorded at higher frequency stimuli. At stimulus levels of 65 dB HLn, latency to the first peak in the FFR decreased as a function of increasing stimulus frequency. Neonatal FFRs evoked by tone bursts of 250 and 500 Hz exhibited significantly longer latencies compared to FFR recordings obtained from adults. These results suggest that: (1) Low-frequency basilar membrane sensitivity in neonates can be assessed as early as the first day of life. (2) The response properties of the FFR recorded from neonates were similar to the response properties of the FFR recorded from the adult. (3) For infants who fail conventional brainstem-evoked response screening procedures and/or for infants who are born "at risk", the FFR holds great promise as an assessment technique to determine the integrity of the low-frequency-sensitive regions of the cochlea and auditory brainstem.

Adult↗
PubMedDate not supplied

Neonatal status: an objective scoring method for identifying infants at risk for poor outcome.

The likelihood of sustaining neurological, sensory or cognitive deficits is considerably greater for very low birthweight (VLBW) infants who require intensive care in early postnatal life than those without major neonatal illness. Identifying which, if any, medical events are responsible for an adverse outcome is most difficult in the face of multiple concurrent complications. In this research, a principal components analysis was performed in order to arrive at a set of orthogonal variables which succinctly described clinical involvement in the nursery. With this procedure, a single hypothetical factor depicting neonatal status (NS) was computed. Principal component scores were then generated for NS and assigned to 252 VLBW (less than 1500 g) infants. These subjects were followed prospectively from birth to 4 years of age. Standardized measures of neurological, sensory and intellectual function were regularly administered. Neonatal status was shown to be significantly correlated with the various test results and predictive of long-term development. When subjects were divided into quartiles with respect to NS, a specific subgroup was identified as "at high risk" for poor outcome. Those subjects falling into the lower quartile incurred more neurological abnormalities persisting beyond the first year. They also suffered a higher incidence of intracranial hemorrhage and sensori-neural hearing loss. In addition, the lower 25%, as a group, scored well below all others on traditional tests of mental ability. These differences were sustained throughout infancy and early childhood and could not be attributed to a number of demographic variables including sex, gestational age, birthweight, Apgar scores or parental educational level.

Child Development↗