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Biomedical subjects

A Salamon

Publications and source records attributed to A Salamon.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver.

BACKGROUND: Amidox (AX) is a novel anticancer drug currently undergoing pre-clinical studies. Though AX shows activity against various tumor cells, its biotransformation is still unknown. MATERIAL AND METHODS: Livers of male Wistar and mutant TR- rats were perfused with AX in a single pass system and bile and effluent perfusate analyzed by HPLC for AX and its metabolites. RESULTS: In bile, seven biotransformation products but not AX could be quantified though their total excretion into bile was low. However, the cumulative efflux of AX metabolites into the effluent perfusate was high with about 55% of AX applied to the liver during perfusion. Biliary excretion of AX metabolites in TR- rats was substantially reduced compared to Wistar rats, indicating that metabolites are substrates of the canalicular multispecific organic anion transporter cmoat. CONCLUSION: Metabolism of AX in rat liver is high and has to be considered during cancer therapy of patients.

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PubMedDate not supplied

Anatomy of the chicken foot for the experimental investigation in flexor tendon surgery.

A chicken model for research in flexor tendon surgery is used despite the considerable differences between avian foot and human hand anatomy. In order to properly correlate and interpret the data collected from such experiments, a reexamination of chicken anatomy and terminology was undertaken. Thirty chicken feet were studied anatomically for tendon-tendon sheath structures including vascularization, flexor systems, and histologic specimens. The data collected show, besides striking similarities between human and avian anatomy, differences critical enough to warrant a reevaluation of previous descriptions of the avian structure.

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