Biomedical subjects

A Saitoh

Publications and source records attributed to A Saitoh.

151 records · Page 9Linked to original sources

PubMedDate not supplied

Successful resection of renal cell carcinoma with tumor thrombi extending into the right atrium: a case report.

Renal cell carcinoma (RCC) is often associated with an extension of tumor thrombi into the inferior vena cava (IVC) and occasionally up to the right atrium. RCC with IVC involvement has a relatively favorable prognosis when it is completely resected. We present a successfully resected case of RCC with tumor thrombi extending into the right atrium. We performed radical right nephrectomy with lymph node dissection and removed the tumor thrombi en bloc under total hepatic vascular exclusion with the veno-venous bypass between the IVC and the right atrium using an active centrifugal force pump. The patient has been in good condition for 3 years since surgery with no evidence of recurrence.

Carcinoma, Renal Cell↗

PubMedDate not supplied

Effects of simvastatin on serum lipids and atherosclerosis in WHHL rabbits.

Watanabe heritable hyperlipidemic rabbits aged three months (young group) or 10 months (adult group) received 10 mg/kg of simvastatin daily for 24 weeks. Serum levels of total cholesterol, triglycerides, and beta-lipoproteins were reduced significantly in the treated animals but not in untreated controls. The decreases were greater in the young than in the adult animals. Levels of high-density lipoprotein cholesterol were not affected by treatment. At 24 weeks, the extent of atheromatous lesions on the thoracic-abdominal aorta was lower in the treated animals than in the controls, but the difference was significant only in the young animals. The results indicate that simvastatin would be effective in the treatment of atherosclerosis.

Age Factors↗

PubMedDate not supplied

1,25-Dihydroxyvitamin D3 decreases the interferon-gamma (IFN-gamma) induced HLA-DR expression but not intercellular adhesion molecule 1 (ICAM-1) on human keratinocytes.

In human epidermal keratinocytes (HKC), it is known that interferon gamma (IFN-gamma) induces Major Histocompatibility Complex (MHC) class II antigens and intercellular adhesion molecule 1 (ICAM-1) expression. 1,25 (OH)2D3, the most active metabolite of vitamin D3, has been shown to be produced by keratinocytes (KC). KC possess receptors for 1,25 (OH)2D3 and could be a target of 1,25 (OH)2D3. Although immunological participation of 1,25 (OH)2D3 has been reported, little is known about its effect on MHC class II Ag expression or ICAM-1 expression. In this article, we investigate the effect of 1,25 (OH)2D3 on IFN-gamma induced MHC class II Ag or ICAM-1 expression of HKC and reveal that 1,25 (OH)2D3 decreases the IFN-gamma induced HLA-DR, but not ICAM-1 expression on HKC.

Antibodies, Monoclonal↗

PubMedDate not supplied

A computerized system for analyzing occlusal relations during mandibular movements.

Articulators have long been used for analyzing occlusal relationships during mandibular movements. However, a comprehensive evaluation of occlusal relationships can be hindered by the instrument as well as the casts. Recent developments in computer technology avoid these limitations by providing the ability to visualize and analyze occlusion. The process is accomplished by recording occlusal form and mandibular movements optically and then digitizing them for computer use. The computer can generate a visual simulation of the patient's occlusion at any position during mandibular movement, which enables analysis of the articulation from any perspective.

Dental Articulators↗

PubMedDate not supplied

Cystic neoplasms of the liver: a report of two cases with special reference to cystadenocarcinoma.

We herein present two cases with cystic neoplasms of the liver, both successfully treated by a surgical resection. One patient underwent a tumor enucleation, while the other had a left hepatic lobectomy and left caudate lobectomy. Although the follow-up period is still relatively short, both patients are doing well without any sign of recurrence. The specimens were histopathologically examined including immunohistochemical staining. Both tumors were unilocular-cystic and contained mucus. One tumor was considered to have originated from a cystadenoma with a mesenchymal stroma, which has been espoused by Wheeler and Edmondson, while the other tumor was considered to have originated from the bile duct. Therefore, the diagnosis of one patient was cystadenocarcinoma, while the other was considered to be a mucin-producing papillary adenocarcinoma of the intrahepatic bile duct. No invasive growth to the liver parenchyma or the surrounding tissues was observed in either case. Thus, a surgical resection should be the first choice of treatment for cystic neoplasms of the liver. Furthermore, a malignant transformation of cystadenoma with a mesenchymal stroma should be given a special entity in cystadenocarcinoma.

Adenocarcinoma, Mucinous↗

PubMedDate not supplied

The effect of a perioperative steroid pulse on surgical stress in hepatic resection.

Little has been reported on the control of cytokine release, which is induced by surgical stress. The aim of this study was to investigate the effect of a perioperative short-term steroid pulse on surgical stress. Seventeen patients with a non-cholestatic liver, who underwent hepatic resection, were included in this study. The patients were classified into two groups consisting of a control group (n = 11) and a steroid pulse group (n = 6), in whom 30 mg/kg of methylprednisolone was intravenously administered 3 hours before the operation, and thereafter 1 gram of methylprednisolone was also intravenously administered both immediately after operation and on postoperative day 1. Interleukin 6 was serially measured, and the perioperative clinical parameters including C-reactive protein were compared between both the control and the steroid pulse groups. The IL-6 values immediately after operation, as well as at postoperative days 1 and 3 in the steroid pulse group were significantly lower than those in the control group. The value of the C-reactive protein at postoperative day 3 in the steroid pulse group was significantly lower than that in the control group, and the postoperative peak value of bilirubin as well as the incidence of postoperative complications in the control group tended to be higher than those in the steroid pulse group. In addition, the steroid pulse demonstrated no adverse side effects. A perioperative short-term steroid pulse using methylprednisolone is thus suggested to reduce surgical stress by decreasing cytokine release.

Aged↗

PubMedDate not supplied

Hepatic vein reconstruction at inferior vena cava confluence using left renal vein graft.

BACKGROUND/AIMS: To preserve remnant liver function, extended left hepatectomy combined with middle hepatic vein reconstruction using a left renal vein graft was performed in resection of liver metastasis from sigmoid colon cancer, involving the confluence of the middle and left hepatic veins. METHODOLOGY: The tumor, 5 cm in size, occupied the superior part of segment 4, and involved the confluence of the middle and the left hepatic veins. An extended left hepatectomy, including the left lobe, left caudate lobe and part of segment 8, together with the middle hepatic vein trunk, was performed. The left renal vein was resected as a graft from the confluence of the inferior vena cava just distal to the branches of the gonadal vein, renal-azygos, splenorenal communications and vertebral veins. The middle hepatic vein was reconstructed using the left renal vein 3 cm in length. RESULTS: Impaired values of liver function tests were normalized by the third postoperative day. Renal function was good throughout the postoperative period. The patient was discharged two weeks after the surgery. The reconstructed middle hepatic vein was patent, which was evaluated by a color Doppler ultrasonography, computed tomography and magnetic resonance imaging 60 days after the surgery. The patient remained well in the eight months thereafter. CONCLUSIONS: Hepatic vein reconstruction using a left renal vein graft is a new and preferable addition for the selection of an optimal graft.

Female↗