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Biomedical subjects

A Saia

Publications and source records attributed to A Saia.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Carotid stenosis and obliteration of the contralateral carotid. A prospective study of the risks of a carotid endarterectomy intervention and its long-term results].

From March 1980 to July 1988 a consecutive series of 256 patients (p.) underwent 301 carotid endarterectomy + patch with routine use of continuous intraoperative EEG monitoring and selective use of an intraluminal shunt (IS) for the presence of an atherosclerotic plaque concerning the internal carotid artery (ICA). Patients were divided in two groups: the first (42 p.) marked by contralateral ICA occlusion, the second (214 p.) without contralateral ICA occlusion (259 CEA). Immediate peroperative, long term and global (immediate and long term) outcomes were prospectively and comparatively studied. A temporary IS was inserted in 27 p. (64%) of the group I and in 38 p. (14%) of the group II. Immediate permanent postoperative neurological deficit occurred in 1 p. of group I (2.38%) and in 2 p. (0.9%) in group II. Immediate postoperative mortality was 0% and 0.9% in group I and II respectively. All p. had neurological valuation and Echo-Doppler of operated ICA and of the contralateral ICA every 6 months (middle follow-up 44 months). New neurological symptoms compared in 5.8% of p. of group I and in 5.23% of p. of group II with a stroke rate of 0% and 2.32% respectively. There were 2 restenosis of operated ICA, both of them in p. of group I, that underwent reoperation. In the two groups the principal causes of deaths were myocardial infarct and cancer; in the group I no death was due to stroke versus 1.86% in the group II.

Aged↗
PubMedDate not supplied

EEG monitoring, selective shunting and patch graft angioplasty in carotid endarterectomy. Early and longterm results.

From March 1980 to July 1986 at the Department of Vascular Surgery of the University of Padua, 182 patients underwent 210 carotid revascularizations for atherosclerotic stenosis involving the carotid bifurcation (28 operations were bilateral). Carotid endarterectomies (CE) and patch graft angioplasty totalled 192 (166 patients); an enlarging patch graft angioplasty of the internal carotid artery (ICA) without CE was performed in 14 cases (13 patients); in the remaining four surgical procedures (3 patients), for technical reasons prohibiting CE, the operation consisted of a great saphenous vein bypass between a donor vessel and the ICA distal to the lesion. The preoperative symptoms in 182 patients were as follows: TIAs (98 cases, 54%), non-hemispheric symptoms (21 cases (12%) and fixed stroke or TIAIR (10 cases, 5%). Fifty-three patients (29%) were asymptomatic. In all cases, continuous EEG monitoring was employed. The operation was performed without a temporary intraluminal shunt in the patients showing tolerance to carotid clamping. The protection of the shunt was required only in patients with EEG changes (47 cases). The arteriotomy was routinely closed with a PTFE patch graft angioplasty. Early results of the operation were excellent: none of the patients presented permanent or transient neurological deficits in the immediate postoperative period and none of them died. All patients were reassessed with C.W. Doppler sonography and Duplex scanning in the postoperative period. In all cases, the success of the operation was demonstrated. Longterm follow-up (6-72 months, mean follow-up: 35 months) was done in 121 patients (142 operations): 107 patients were completely asymptomatic, 5 remained stable or slightly improved the preoperative status. Five patients had a new or recurrent TIAs, 3 suffered a stroke, one showed a recurrence of non-hemispheric symptoms. With the exception of two patients suffering a stroke, all had a second arteriography but none of these patients showed extracranial lesions. Two patients presented an asymptomatic restenosis of the ICA. Eight patients (8.8%) revealed a significant evolution of the disease of the contralateral unoperated ICA.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMedDate not supplied

[Use of substances modifying serotonin metabolism in the treatment of narco-cataplexy (considerations on 5 cases)].

The AA., after a critical analysis of the new proposed treatments for the narco-cataplexy, report their experience about the therapeutic possibilities of this syndrome with particular manipulations of cerebral serotonin (5-HT). In 5 patients they tried to act on the two sides of the sleeping-waking cycle by using a diurnal administration of Methysergide (5-HT inhibitor) and an evening loading of L-Tryptophan combined with Benserazide (dopa-decarboxilase inhibitor). The immediate and long term results on the nercoleptic as well as cataplectic symptoms can be considered good. Conversely treatments with Clomipramine alone exerted poor beneficial effects in these patients. The AA. discuss the physiopathogenetic mechanisms which are thought to be involved in this disease.

Adult↗
PubMedDate not supplied

[Possible activating effect of subnarcotic doses of some anaesthetic drugs in clinical electroencephalography (author's transl)].

The use of subnarcotic doses of anaesthetic agents has been proposed, in the last few years, as a practical method for enhancing EEG activities in epileptic patients. Barbiturates such as Evipan or Brietal were used in the present study. Both electrographic and clinical effects occurred not only with the intravenous administration fo Brietal and Evipan but also with Althesin (a new non-barbiturate drug), in two groups of suspected and confirmed epileptics having either a normal or specific EEG pattern. These results were then compared with a normal control group. In a high percentage of instances all these drugs were found to induce either focal or generalized increase of epileptiform activities, as well as the appearance of latent epileptic abnormalities. The AA. stress the advantages these new techniques as ascreening method in suspected epilepsy.

Adolescent↗
PubMedDate not supplied

[EEG in transient ischemic attacks (author's transl)].

60 patients under 65 years of age with one or more episodes of reversible ischemic attacks lasting less or more than 24 hours (T.I.A. or R.I.N.D.) were studied. Each patient had a complete clinical assessment and an EEG, followed by an arteriogram. 35 patients had an EEG activation with digital carotid compression. EEG abnormalities were present in 26 cases while 34 patients had normal records. No correlation was found between EEG abnormalities and arteriographic alterations. EEG activation by digital carotid compression is a valuable hemodynamic test but cannot necessarily indicate a controlateral carotid artery occlusion.

Adult↗
PubMedDate not supplied

[Ophthalmodynamometry in transitory cerebral ischemic episodes].

The authors examine the diagnostic accuracy of ophthalmodynamometry in detecting extracranial internal carotid artery stenosis. 58 patients with T.I.A.s or R.I.N.D.s are studied. The test, compared with angiography, is positive only in 50% of patients presenting unilateral internal carotid artery occlusion.

Carotid Artery Thrombosis↗
PubMedDate not supplied

Regional cerebral blood flow compared to angiography in ischemic cerebrovascular diseases.

Regional cerebral blood flow determination, following post-angiographic intracarotid injection of 133Xenon, was performed in 11 patients with transient (T.I.A. - R.I.N.D.) or established (Stroke) cerebrovascular disorders. The regional cerebral perfusion rate of the grey matter was compared with angiographic data. There was a good correlation between angiographic abnormalities and regional cerebral perfusion rate disturbances. The Authors emphasize the presence of regional cerebral perfusion rate disturbances (not shown by angiography) even some time after transient ischemic episodes.

Adult↗
PubMedDate not supplied

[Achondroplasia is also a neurologic disease].

The achondroplasics' ossification defect produce some changes of the spinal column of such a degree to cause a medullary compression. The AA. refer two cases of neurological complication hospitalized since 1960 in the Clinica delle Mlattie Nervose e Mentali - University of Padua. The clinical evolution of the two patients is considered and compared with the cases known in the Literature; the pathogenetic mechanisms of this disease and the therapeutical perspective are discussed too.

Achondroplasia↗