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Biomedical subjects

A SJOERDSMA

Publications and source records attributed to A SJOERDSMA.

At least 73 records · Page 4Linked to original sources
PubMed1960

Decarboxylase inhibition and blood pressure reduction by alpha-methyl-3,4-dihydroxy-DL-phenylalanine.

alpha-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.

Amino Acids↗
PubMed1959

Serotonin.

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Serotonin↗
PubMed1959

Alterations in the pattern of amine excretion in man produced by a monoamine oxidase inhibitor.

The administration of monoamine oxidase inhibitors produces an increase in the urinary excretion of many amines for which efficient alternate routes of metabolism are not available. These include tryptamine, paratyramine, and a "metatyramine-like" substance. The inhibitors can therefore be used to detect previously unsuspected pathways of amino acid decarboxylation. The finding that the excretions of norepinephrine, epinephrine, 3,4-dihydroxyphenylethylamine, and possible serotonin are not appreciably affected are consistent with previous reports of the existence of alternative metabolic routes.

Amines↗
PubMed1959

Serotonin.

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Serotonin↗