URINARY EXCRETION OF PHENOLIC ACIDS IN HUMAN SUBJECTS ON A GLUCOSE DIET.
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Biomedical subjects
Publications and source records attributed to A SJOERDSMA.
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Human plasma contains hydroxyproline in a bound form that is nondialyzable, is precipitable with the usual protein precipitants, can be extracted with hot trichloroacetic acid, and is released on hydrolysis in 6N HCI. These properties resemble those of collagen and suggest that small amounts of this connective tissue protein (3 to 5 mg per 100 ml), or a very large peptide derived from it, normally circulate in the blood. The identification and analysis of hydroxyproline in hydrolyzates of plasma protein were based on isotope-dilution procedures.
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The isolated, perfused guinea pig heart contains all the catalysts required to form norepinephrine from the dietary precursor, tyrosine. The conversion of tyrosine-C(14) to norepinephrine in the perfused heart occurred at a rate comparable to that estimated for this conversion in vivo. To account for the maintenance of norepinephrine stores in the normal heart, it is not necessary to postulate that the hormone is extracted from the blood.