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Biomedical subjects

A S Wilson

Publications and source records attributed to A S Wilson.

At least 37 records · Page 2Linked to original sources
PubMed1990

Effects of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate on mouse osteoclasts.

A group of 5-day-old mice were injected intraperitoneally with (3-amino-1-hydroxypropylidine)-1,1-bisphosphonate (APD). Morphologic changes were observed in vitally stained osteoclasts on parietal bones 3 days later, and these were judged to be degenerative. At this time significantly increased numbers of nuclei per osteoclast and total numbers of osteoclast nuclei were observed. However, at 4 days after the injection of APD, the total numbers of osteoclasts were significantly reduced relative to controls. When parietal bones were maintained in culture, APD reduced osteoclast numbers and inhibited cell-mediated 45Ca2+ release. Exposure of bones to parathyroid hormone increased the number of osteoclasts counted 1 day later. This effect was not blocked by APD. Calcitonin prevented the reduction in osteoclast numbers due to APD in vitro. We conclude that APD has a direct effect on resorbing mouse osteoclasts.

Animals↗
PubMed1990

Detection of frequency modulation (FM) in the presence of a second FM tone.

A series of three experiments was undertaken to investigate detection of sinusoidal frequency modulation (FM) in the presence of FM at a separate frequency. The first experiment measured detection of modulation for an FM tone with a modulation frequency (fm) of 6 Hz as a function of carrier frequency (fc) under three conditions: (1) in quiet, (2) in the presence of a 2500-Hz pure tone, and (3) in the presence of a 2500-Hz FM tone with fm = 6 Hz, modulating in phase with the signal. Detection of FM in the presence of the second FM tone was worse than for either the signal presented in quiet or in the presence of the unmodulated tone. Threshold varied as an inverse function of frequency separation between the signal and the masker. In the second experiment, FM detection for a signal with fc = 1900 Hz and fm = 6 Hz was measured as a function of the modulation frequency (fm = 2-18 Hz) of the 2500-Hz masker tone. FM detection improved significantly with increasing difference between the modulation frequencies of the signal and the masker. The final experiment measured detection of FM for a signal (fc = 1900 Hz, fm = 6 Hz) in the presence of a second FM tone (fc = 2500 Hz, fm = 6 Hz) as a function of the relative phase of the 6-Hz modulators. Detection of FM improved monotonically as a function of increasing phase difference between the two modulators. The results are discussed in terms of modulation detection interference and perceptual grouping.

Adult↗
PubMed1982

The human lumbar dorsal rami.

The L 1-4 dorsal rami tend to form three branches, medial, lateral, and intermediate, which are distributed, respectively, to multifidus, iliocostalis, and longissimus. The intertransversarii mediales are innervated by a branch of the dorsal ramus near the origin of the medial branch. The L 4 dorsal ramus regularly forms three branches while the L 1-3 levels the lateral and intermediate branches may, alternatively, arise from a short common stem. The L 5 dorsal ramus is much longer than the others and forms only a medial and an intermediate branch. Each lumbar medial branch innervates two adjacent zygapophysial joints and ramifies in multifidus, supplying only those fascicles which arise from the spinous process with the same segmental number as the nerve. The comparative anatomy of the lumbar dorsal rami is discussed and the applied anatomy with respect to 'rhizolysis', 'facet denervation' and diagnostic paraspinal electromyography is described.

Adult↗
PubMed1981

The nerve supply to the human lumbar intervertebral discs.

The lumbar intervertebral discs are supplied by a variety of nerves. The posterior aspects of the discs and the posterior longitudinal ligament are innervated by the sinuvertebral nerves. The posterolateral aspects of the discs receive branches from adjacent ventral primary rami and from the grey rami communicantes near their junction with the ventral primary rami. The lateral aspects of the discs receive other branches from the rami communicantes. Some rami communicantes cross intervertebral discs and are embedded in the connective tissue of the disc deep to the origin of psoas. Such paradiscal rami are likely to be another source of innervation to the discs. The anterior longitudinal ligament is innervated by recurrent branches of rami communicantes.

Humans↗
PubMed1980

The morphology of the surface of artcular cartilage in adult rats.

Articular cartilage from the weight-bearing area of the femoral concyles in adult rats is smooth in the normal, non-weight-bearing condition, showing none of the surface irregularities (8-15 micrometer) reported by previous authors. Demonstrable changes in the surface characteristics of articular cartilage may be attributable to preparation procedures. The normal smoothness observed in TEM studies has been confirmed by an SEM method. 'Quarternary ridges' described as evidence of ageing may be analogous to 'wrinkles' observed on the surface cartilage exposed to ambient atmospheric conditions.

Animals↗
PubMed1978

Personality characteristic of the female alcoholic.

Utilized the Personal Reaction Inventory (PRI-100) on a sample of 47 hospitalized female alcoholics and a control group of 47 individually matched nonalcoholic Ss. A measure of drinking behavior was established by the Volume Variability Index (V/V) administered to each S immediately prior to the administration of the PRI-100. A test-retest experimental design over a 2-week period yielded an average reliability coefficient of .88 for the PRI-100. The findings show that the personality characteristics associated with Assertive Antisocial Behavior, one of the factors of the PRI-100, are valuable predictors of drinking behavior. The two other personality factors of the PRI-100, Lack of Order and Lively Social Presence, were found to be unrelated to drinking behavior and therefore inadequate predictors.

Alcohol Drinking↗