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Biomedical subjects

A S Willsky

Publications and source records attributed to A S Willsky.

5 recordsLinked to original sources

Modeling of cardiac rhythms. A signal-processing perspective.

The authors describe their perspective on the modeling of cardiac rhythms as a component of cardiac arrhythmia signal-processing algorithms. They emphasize that these models are for a specific end purpose and that the aspects of cardiac behavior that are captured by the models are only those relevant for the development of the signal-processing algorithms. The approach is to use statistics to describe ranges of cardiac behavior that share some common feature with respect to the purpose of the signal processing. The statistical approach has the advantage that, coupled with a statistical performance criterion, it specifies an optimal signal-processing algorithm. These optimal algorithms are often computationally intractable, however, especially for real-time use in instruments. Approximations are therefore crucial. The mathematical form of the model is then important since, even if two forms generate identical statistics, the approximations that are natural in different forms can be quite different. Two different mathematical formulations are described--stochastic Petri nets and interacting Markov chains--and the different types of approximately optimal signal-processing algorithms that are natural in these two frameworks are discussed.

Algorithms↗

Stochastic Petri net modeling of wave sequences in cardiac arrhythmias.

We describe a methodology for modeling heart rhythms observed in electrocardiograms. In particular, we present a procedure to derive simple dynamic models that capture the cardiac mechanisms which control the particular timing sequences of P and R waves characteristic of different arrhythmias. By treating the cardiac electrophysiology at an aggregate level, simple network models of the wave generating system under a variety of diseased conditions can be developed. These network models are then systematically converted to stochastic Petri nets which offer a compact mathematical framework to express the dynamics and statistical variability of the wave generating mechanisms. Models of several arrhythmias are included in order to illustrate the methodology.

Arrhythmias, Cardiac↗