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Biomedical subjects

A S Ward

Publications and source records attributed to A S Ward.

63 records · Page 4Linked to original sources
PubMed1970

Oesophageal reflux and gastric secretion.

In the study to be described confirmation of the findings of Giles, Clark, and Buchan (1968) that the presence of acid in the lower oesophagus may stimulate gastric secretion has been sought. Also the influence of hiatal repair on the response to acid has been examined. The presence of acid in the lower oesophagus stimulates gastric secretion in man. The response to acid perfusion is greater in symptomatic hiatus hernia patients than in controls. Basal and perfusion outputs are lower in hiatus hernia patients with oesophagitis than in those without inflammatory change. Hiatal repair diminishes the gastric response in both groups; this effect is particularly marked in patients with oesophagitis.

Esophagitis↗
PubMed1969

Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer.

Gastric secretion in man is inhibited by the presence in the duodenum of hyperosmolar and hypoosmolar solutions. Both acid and pepsin outputs are affected. There is no change in hydrogen, sodium, or potassium ion concentration in the gastric juice. Pepsin concentration, however, is reduced by all inhibitory stimuli. Inhibition is thought to act directly upon parietal and chief cells, and a possible basis for this mechanism is discussed. The response is similar in control subjects and duodenal ulcer patients; there is in particular no evidence of impaired inhibition in the ulcer group. An anomalous feature is the relatively small inhibition of acid output after hypertonic saline in control subjects compared with the duodenal ulcer patients.

Adult↗
PubMedDate not supplied

Salmonella infection of a Dacron aortic bifurcation graft.

We report a case of primary salmonella infection of a dacron aortofemoral bypass graft. Local graft excision with extra-anatomic bypass resulted in a successful outcome. Salmonella, whilst the commonest cause of infected abdominal aortic aneurysms, is currently a rare cause of prosthetic graft infection. However, given the increasing prevalence of salmonellosis in the community, we believe this situation will change and surgeons should be alert to this new and dangerous addition to the list of graft pathogens.

Aorta, Abdominal↗
PubMedDate not supplied

Infection complicating aortoiliac surgery.

25 cases of sepsis complicating aorto-iliac surgery have been encountered in the period 1970 to 1976 (8 cases occured in our own unit and 17 were received from elsewhere). There were 10 instances of infection following thromboendarterectomy and all 10 were treated successfully. Among the 19 patients with infected prostheses (14 primary, 5 secondary) there were 5 deaths(1 myocardial infarct, 2 septicaemia, 2 aortic haemorrhages) and 3 amputations. The treatment of choice for infected thromboendarterectomy cases is iliac exclusion coupled with either an obturator by-pass or a femoro-femoral vein graft using the perineal route. An infected prosthesis should be removed and circulation restored by means of an axillofemoral-bypass, or a femoro-femoral vein graft or a combination of the two. Occasionally an infected aorto-femoral prosthesis can be treated by removal of one limb only followed by obturator or axillo-femoral by-pass. The prophylactic value of omentopexy in aortoiliac surgery is emphasised.

Amputation, Surgical↗