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Biomedical subjects

A S Sørensen

Publications and source records attributed to A S Sørensen.

17 recordsLinked to original sources
PubMed2006

Quantum optics with surface plasmons.

We describe a technique that enables strong, coherent coupling between individual optical emitters and guided plasmon excitations in conducting nanostructures at optical frequencies. We show that under realistic conditions optical emission can be almost entirely directed into the plasmon modes. As an example, we describe an application of this technique involving efficient generation of single photons on demand, in which the plasmon is efficiently outcoupled to a dielectric waveguide.

Journal Article↗
PubMed2006

Fault-tolerant quantum communication based on solid-state photon emitters.

We describe a novel protocol for a quantum repeater that enables long-distance quantum communication through realistic, lossy photonic channels. Contrary to previous proposals, our protocol incorporates active purification of arbitrary errors at each step of the protocol using only two qubits at each repeater station. Because of these minimal physical requirements, the present protocol can be realized in simple physical systems such as solid-state single photon emitters. As an example, we show how nitrogen-vacancy color centers in diamond can be used to implement the protocol, using the nuclear and electronic spin to form the two qubits.

Journal Article↗
PubMed2004

Stability of atomic clocks based on entangled atoms.

We analyze the effect of realistic noise sources for an atomic clock consisting of a local oscillator that is actively locked to a spin-squeezed (entangled) ensemble of N atoms. We show that the use of entangled states can lead to an improvement of the long-term stability of the clock when the measurement is limited by decoherence associated with instability of the local oscillator combined with fluctuations in the atomic ensemble's Bloch vector. Atomic states with a moderate degree of entanglement yield the maximal clock stability, resulting in an improvement that scales as N(1/6) compared to the atomic shot noise level.

Journal Article↗
PubMed2001

Entanglement and extreme spin squeezing.

For any mean value of a Cartesian component of a spin vector we identify the smallest possible uncertainty in any of the orthogonal components. The corresponding states are optimal for spectroscopy and atomic clocks. We show that the results for different spin J can be used to identify entanglement and to quantify the depth of entanglement in systems with many particles. With the procedure developed in this Letter, collective spin measurements on an ensemble of particles can be used as an experimental proof of multiparticle entanglement.

Journal Article↗
PubMed1992

[Why do patients change physicians?].

The purpose of this investigation was to describe why patients change their general practitioners (GP) by the means of questionnaires. Questionnaires were given 357 patients who had changed GPs in 1990 and 206 (58%) returned the questionnaire. The most common reasons were dissatisfaction with the quality of the service provided, too little time allowed or lack of communication between patient and doctor. Women accounted for approximately 75% of the total number and preferred female GPs, whereas men who changed doctors probably did so because they wanted to have the same GP as their families. The frequency of change was about 1% and most of the patients had stuck to the same GP for several years before changing.

Adolescent↗
PubMed1990

Sexual dysfunction in male and female patients with epilepsy: a study of 86 outpatients.

Sexual dysfunction is a well-known complication of chronic somatic illness. Eighty-six consecutive epileptic outpatients, 38 men and 48 women, without accompanying disorders, were studied. The frequency and symptoms of sexual dysfunction were compared with results from previous studies using identical sexological methodology. The previous studies were of diabetic patients and healthy controls. Eight percent of the epileptic men reported a sexual dysfunction compared to 44% of the diabetics and 13% of the controls. Epileptic women, diabetic women, and controls showed no significant differences in sexual dysfunction (29%, 28%, and 25%, respectively). In both sexes, the sexual function measured by frequencies of coitus and masturbation was normal. Most patients had good control of epileptic attacks on a treatment of monotherapy. Hormonal status was generally within normal limits in both men and women; only a few minor differences were found and they showed no correlation with sexual dysfunction. Psychologically and socially the patients did not differ appreciably from normals, and they exhibited a high degree of disease acceptance. This study, using a biopsychosocial approach in understanding sexual dysfunctions, is in contrast with previous, mainly uncontrolled, studies of epileptic patients that reported high frequencies of "hyposexuality" in males. We conclude that epilepsy does not necessarily increase the risk of sexual dysfunction in male or female.

Adult↗
PubMed1989

[Addiction to drugs and alcohol among physicians and nurses].

A retrospective investigation based on case reports was undertaken concerning abuse of alcohol and drugs among medical staff, 44 doctors and 23 nurses, who were treated in the Department of Psychiatry, Rigshospitalet during the period 1970-1982, all of whom received treatment for more than six months. By the end of 1987, a marked excessive mortality was found and this was greatest among doctors among whom 50% had died with an average age of 45.5 years. Factors which were found to be of significance for the prognosis for duration of survival in this selected material were 1) duration of the abuse of medicine, 2) presence of mixed alcohol and drug abuse and 3) previous suicidal attempts.

Adult↗
PubMed1989

Personality characteristics and epilepsy.

Patients with a long history of temporal lobe epilepsy or primary generalized epilepsy entered a questionnaire study of personality characteristics, based on a modification of the Bear-Fedio inventory for temporal lobe behavioural syndrome. Psoriasis patients and healthy volunteers served as controls. Four clinical meaningful dimensions of included personality traits were identified: ixoide, ideational, obsessive-compulsive and affective features. Analyses based on the Rasch model approved of all dimensions except for affective features. The epilepsy group obtained the highest scores on all 3 dimensions, healthy volunteers the lowest, while the psoriasis group repeatedly held an intermediate position in all sets of assessment (subjects, interviewers and relatives). A logistic regression analysis showed ixoide features being most important when the entire epilepsy group was compared with other study groups, while the dimension ideational features was significant when the temporal lobe epilepsy group was entered as target group and opposed to primary generalized epilepsy. The intermediate position of the psoriasis group, however, suggests that in addition to the presence of a cerebral dysfunction in the epilepsy group, the mere presence of a chronic disorder with potential social stigmatization influences personality.

Adult↗
PubMed1988

Ego functions in epilepsy.

Two groups of epilepsy patients (28 patients with temporal lobe epilepsy and 15 patients with primary generalized epilepsy) entered a study of personality traits related to epilepsy, based on a modification of Bellak's semistructured interview for assessment of ego strength. Two groups of subjects served as controls: 15 patients with a non-neurological but relapsing disorder, psoriasis, and 15 healthy volunteers. Compared with the group of healthy volunteers, a decreased adaptive level of ego functioning was found in the epilepsy groups, regardless of seizure types and EEG findings, and, to a lesser extent, compared with the psoriasis group. Areas of ego functioning most affected were "reality testing", "cognitive functioning", "integrative functioning" and "regulation and control of drives". Patients with more than one type of seizure were the most affected, as were patients who were younger than 15 years when the disease began. The number of anticonvulsants administered did not influence the results. No difference on adaptive level of ego functioning was found between the group with primary generalized epilepsy and the group with temporal lobe epilepsy. Similarly, the temporal lobe epilepsy group with predominantly right-sided and left-sided EEG changes, respectively, showed similar adaptive levels of ego functioning.

Adult↗
PubMed1988

Cerebral blood flow during delirium tremens and related clinical states studied with xenon-133 inhalation tomography.

The regional cerebral blood flow of 12 patients with severe alcohol withdrawal reactions (delirium tremens or impending delirium tremens) was measured during the acute state before treatment and after recovery. Greater cerebral blood flow was significantly correlated with visual hallucinations and agitation during the acute withdrawal reaction. The results suggest that delirium tremens and related clinical states represent a type of acute brain syndrome mainly characterized by CNS hyperexcitability.

Adult↗
PubMed1986

Femoxetine and cimetidine: interaction in healthy volunteers.

The possibility of a pharmacokinetic interaction between femoxetine and cimetidine has been evaluated in 8 healthy volunteers. Two volunteers received single doses of femoxetine, and 6 were given multiple doses of femoxetine for 7 days with and without concurrent cimetidine. No influence of cimetidine was observed on the kinetics of single doses of femoxetine, but after multiple doses the plasma concentration of femoxetine was significantly increased. Similarly, the AUC at steady state tended to be increased, but not to a significant extent. Concurrent cimetidine did not cause a reduction in the AUC of the active desmethyl metabolite. It is recommended that femoxetine is given in reduced doses (e.g. 400 mg) when administered with cimetidine.

Adult↗
PubMedDate not supplied

5-HT and 5-HIAA in cerebrospinal fluid in depression.

CSF 5-HT and 5-HIAA were measured in endogenously depressed patients (ICD-9) (n = 23) and controls (n = 11). Distribution of sex, age and body height was similar in the two groups. Non-parametric statistics were used. In depressed patients CSF 5-HT concentrations were found to be higher (P less than or equal to 0.01) than in controls. A further classification of the depressed patients by the Newcastle Scale showed that the highest values were found in the endogenous group compared to the non-endogenous group (P less than or equal to 0.02). CSF 5-HIAA was found to be equal in the two groups, even when pairs matched for height were compared. No relation between clinical recovery due to drug treatment and changes in CSF 5-HT was seen. Our data support a possible involvement of 5-HT in the biology of depression, but the anatomical and functional levels of a serotonin derangement are still unknown.

Amitriptyline↗