Biomedical subjects
Publications and source records attributed to A S Rose.
Results indicate that A. salmonicida does not enter an unculturable dormant state. The resuscitation of dormant cells by nutrient broth described by previous workers appears to be due to the presence of small numbers of viable, culturable cells too few to be detected by the sampling protocol employed.
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Multiple sclerosis is a chronic disease with varying degrees of disability and progression. Because there is no known specific therapy, for best care, patients are individualized, with attempts to deal with each patient and each complication separately, thoughtfully, and with psychological support when required. Efforts are directed toward helping the patient adjust to the realities of the disease and to specific disabilities. Ways and means of gaining patient confidence are discussed--and emphasis is placed on the known pathologic processes involved and how information, personalized professional attention, and support might function to aid the body's defense mechanisms for containment of the disease process. Several clinical cases were summarized (at the symposium) to illustrate the favorable and unfavorable effects of personality and emotional characteristics over a long term of care.
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From 1965 to 1968 a multicenter (USA) clinical trial was conducted to compare ACTH with placebo for the treatment of multiple sclerosis patients in a stage of acute exacerbation. Of seven evaluation systems which were used, one was a quantitative neurological examination. In this report, the quantitative neurological data have been re-evaluated using a transformation of the data which express patient scores in terms of a percentage of age- and sex-matched normal function followed by a reduction of the data into composite neurological functions vs time. The results support the positive findings of previous reports. In addition, the methodology helps to simplify the therapists' task of interpreting results by enabling him to determine how near normal function the patient came following the treatment trial.
Some practical neurological ideas concerning the nature of mind are presented to assist clinicians in appreciating the fact that brain physiology first creates and then serves the mind--the highest of the hierarchical functions of the nervous system. The qualities of the mind are shaped and modulated by life experience and many disturbed responses can be tempered by a knowledgeable approach. To gain a holistic concept of the functioning nervous system one must recognize and accept that all manifestations of behavior, including those termed psychological, are the product of physiological processes.
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