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Biomedical subjects

A S Narayanaswamy

Publications and source records attributed to A S Narayanaswamy.

14 recordsLinked to original sources

Ring enhancing CT lesions--a diagnostic dilemma.

We studied 68 such cases of RECTL with follow up ranging from 3 months to 3 years. Patients were divided into 3 groups depending on the size of ring ie. Group I (less than 5 mm), Group II (5-10 mm), Group III (10-20 mm). Maximum cases were in Group II (42), in the age group 20-40 years. 60 cases presented with seizures. Single ring was seen in 46 cases and multiple rings in remaining 22 cases. There were 22 cases of tuberculoma, 15 neurocysticercosis, 15 disappearing lesions, 4 malignancy, 2 abscess, 1 each showing infarction and gliosis and 8 of unknown etiology. Partial or total excision biopsy was done in 18 cases of which 3 were due to tuberculoma, 7 neurocysticercosis, 4 tumours, 2 abscess and 1 each due to infarction and gliosis. We found that RECTL could be a real diagnostic problem, which could be solved only be repeated clinical examination and CT Scan with excision biopsy in some selected cases.

Diagnosis, Differential↗

Polymyositis--a review and follow up study of 24 cases.

Twenty-four cases of polymyositis, 3 (12.5%) of them Dermatomyositis, have been treated and followed up for over 12 years. Majority (75%) were males. Inflammatory lesion was the cause in 18 (75%), collagen disease in 4 (16.7%) and malignancy in 2 (8.35%). Presenting features were fever (100%), proximal muscle weakness (95.8%) and tenderness (54.2%), facial and respiratory muscle weakness (4.2%). Raised CPK and transaminases, electromyogram abnormality and positive muscle biopsy were recorded in all. All were treated with steroids. Complication/associations noted were arthalgia (25%), dysphagia (20.6%), peripheral neuritis (8.35%), diabetes mellitus (4.2%), pulmonary fibrosis (4.2%) and malabsorption (4.2%). Fourteen cases (58%), all of inflammatory aetiology, recovered completely. Seven cases (29.2%) developed permanent atrophy of affected muscles. Cases with collagen disease and malignancy fared worse and deteriorated because of the primary disease.

Adult↗

Neurological manifestations of leukemia--clinical and pathological findings.

Out of 70 cases of leukemia studied, 19 had neurological manifestations. All cases were autopsied. Leukemic infiltrates and intracranial hemorrhages produced various neurological manifestations. In autopsied cases 37.2% showed infiltrative changes. Intracranial hemorrhages contributed to 20%, the cause of which were due to thrombocytopenia and leukostasis. Leukemic nodules, demyelination and astrocytosis, gliosis were also seen on histopathology.

Adolescent↗

Neurological manifestations of malignant diseases.

Four hundred and sixty three patients with malignant diseases were studied over a period of two years; of these, 53 (11.44%) had neurological syndrome, both metastatic (32) and non metastatic (21). The lymphoma-leukaemia group accounted for 34 of the 53 cases. The maximum manifestations were seen in the 21-40 years age group, with male preponderance. The metastatic manifestations were as a result of cerebral (16), brainstem, cerebellar (12) and cord (4) deposits. These were confirmed by CT scan and myelogram. The non metastatic manifestations were peripheral neuropathies (7), leukoencephalopathy and intracranial haemorrhage (6 each), and myasthenic syndrome and myopathy (one each). These findings were confirmed by electrophysiological studies, CT scan, and histopathological examination. Autopsy studies were carried out in 12 of the 53 cases.

Adolescent↗

Heat stroke.

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Adult↗

Neurological complications following acute viral conjunctivitis: a new profile.

A study of eleven patients presenting with neurological complications following acute viral conjunctivitis, mostly haemorrhagic, is reported and the literature reviewed. A Guillain-Barre syndrome-like profile was seen in six patients while the remaining had features of radiculomyelitis. Besides asymmetrical neurological deficits, protein cell reaction and residual muscle wasting, the occurrence of dysautonomias was the striking feature noted in the patients with a Guillain-Barre syndrome-like profile. The dysautonomic features included fatal paroxysmal hypertensive and hypotensive crises in one patient and self limiting tachycardias, episodic profuse sweating, abnormal expiration-inspiration ratio and valsalva ratio in four patients. High antibody titers to EV-70 virus were seen in five patients. A follow up of one and a half year revealed poor neurologic recovery in patients with radiculomyelitis as compared to good functional recovery in others. The importance of early recognition and appropriate treatment of dysautonomias is emphasised. The probable aetiopathogenesis of the neurological complications including dysautonomias is discussed.

Adolescent↗

Eating epilepsy.

Three young male patients are described in whom the attacks of epilepsy were precipitated by eating. The interictal EEG was abnormal in 2 cases. One showed generalized seizure discharges; the other unilateral and generalized seizure discharges. The attacks could only partially be controlled with anticonvulsants. Various mechanisms which may be responsible in precipitating the seizures are discussed.

Adult↗