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Biomedical subjects

A S Iagunov

Publications and source records attributed to A S Iagunov.

At least 19 recordsLinked to original sources
PubMed1998

[Cerebrospinal fluid sorption in patients with heroin addiction].

The sorption of cerebrospinal fluid (CSF) was attempted as a special detoxifying procedure in a group of sixty heroine addicts. CSF contents of cells, total protein, nucleic acids and interleukin-1 (IL-1), as well as acridine orange (AO) binding to CSF cells were determined before and after the procedure. The treatment provided immediate clinical improvement for 70% of the patients. Clinical effect was accompanied by decreased of CSF cells, diminished nucleic acids and protein amounts, along with increased DNA-AO binding and accumulation of IL-l. These data are interpreted in terms of intensive apoptosis of CSF cells and increased acute phase of aseptic inflammation-like events induced by the procedure of liquor sorption.

Cerebrospinal Fluid↗
PubMed1991

[The mechanism of the formation of a circadian rhythm of bone marrow proliferation in rats].

Flow cytofluorimetry and statmokinetic method were used to study the circadian rhythm of bone marrow proliferation in Pliss' lymphosarcoma-bearing and intact rats. These data were compared to those obtained in the study of the mitotic activity of the bone marrow in cancer patients. It was found that, already at early stage, tumor affected the circadian rhythm of bone marrow proliferation, reducing the amplitude of oscillations. A model simulating formation of the circadian rhythm of the bone marrow was suggested basing on the possibility to arrest cells at the end of G1 phase. The rate of transition of G1 cells to S phase was determined not only by endogenous "set-points" of the rhythm which formed the basic wave of proliferation but also by conditions of animal upkeep.

Animals↗
PubMed1980

[Pulse flow cytofluorimeter for the UV region of the spectrum].

A high-speed flow system for the automatic analysis of cells has been described. This device can register the fluorescence staining and ultra-violet fluorescence intensity of cells. The rate of measurement is more than 1000 cells per second. The resulting signals are processed and displayed as frequency distribution histograms, using a multichannel pulse height analyser.

Cytological Techniques↗
PubMed1976

[Study of mouse liver cell phosphorescence at deep cooling].

The spectrum and decay curves of phosphorescence of mouse liver cells at --180 degrees C was studied using the phosphorescence microscope. The phosphorescence studied was shown to involve two components with different life spans. Part of either component in the total spectrum is estimated. A conclusion is made that at least two different centers (or groups of centers) exist in cells with the same spectral region of phosphorescence with highly diverging life times of triplet states.

Animals↗
PubMedDate not supplied

[The combained effects of the long-term gamma-irradiation and heavy metall ions on the haematopoietic system of rats].

The combiened effects of different dose rates (0.625 microGy/s - 1.1 mGy/s) of gamma-irradiation and of cuprum and of cadmium ions on the haematopoietic system of rats were studied. It was found that only low dose rates (0.625-10 microGy/s, summary doses 0.5-2.0 Gy) of gamma-irradiation yields in the increasing proliferative activity of bone marrow. The number of myelocariocytos in S-phase was increased at 1.5-1.8 times. In case of the treatment with both cadmium chloride and radiation the changes in proliferative activity of bone marrow are completely due to the radiation factor. Combination of cuprum acetate and ionizing radiation induce opposite effects providing formal normalization of the haematopoietic characteristic of bone marrow up to 3, 6 and 12 months after the end of the radiation and the chemical exposure of the animal.

Animals↗