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Biomedical subjects

A S Highet

Publications and source records attributed to A S Highet.

At least 37 records · Page 2Linked to original sources
PubMed1994

Myxoedematous infiltrate of the forehead in treated hypothyroidism.

A 42-year-old man presented with a 3 month history of erythema and thickening of the forehead skin. He had been diagnosed as hypothyroid 10 years previously and treated with thyroxine at adequate dosage, according to thyroid function tests. Histology confirmed a myxoedematous infiltrate. The forehead is an unusual site for deposition of mucin and the late appearance, 10 years after treatment, is also uncharacteristic. Myxoedema in the usual pretibial site is a feature of Graves' disease. This man, however, had been hypothyroid with no features of Graves' disease suggesting that there are additional factors other than thyroid status and thyroid autoimmune disease which may be important in the development of myxoedematous infiltrates.

Adult↗
PubMed1994

Pyoderma gangrenosum associated with paroxysmal nocturnal haemoglobinuria.

A case of pyoderma gangrenosum of the lip occurring in association with paroxysmal nocturnal haemoglobinuria is described. This is an extremely rare association, which has been documented in the literature on only two previous occasions. Pyoderma gangrenosum (PG) is an uncommon ulcerative skin disorder of unknown aetiology. Its clinical appearance is often distinctive, with established lesions consisting of a necrotic ulcer surrounded by a ragged undermined violaceous edge. Lesions are usually painful and are most often found on the lower limbs but can occur on the trunk, head and neck. The diagnosis is essentially clinical as there are no characteristic histopathological changes. Since its original description in 1930, PG has been frequently associated with a number of underlying systemic diseases. Foremost among these are inflammatory bowel disease and inflammatory polyarthritis. The association with haematological disorders is also well recognized, and includes acute and chronic lymphocytic and myeloid leukaemias, polycythaemia rubra vera, myelofibrosis, myelodysplastic syndrome, essential thrombocythaemia, hypogammaglobinaemia, monoclonal gammopathy, multiple myeloma and non-Hodgkin's lymphoma. We report a case of PG occurring on the lower lip of a 26-year-old man recently diagnosed as having paroxysmal nocturnal haemoglobinuria (PNH).

Adult↗
PubMed1994

Notalgia paraesthetica--report of an association with macular amyloidosis.

We report three patients with notalgia paraesthetica. In two of our cases amyloid deposits were found on skin biopsy. Symptoms had been present in both cases for a number of years. It is well recognized that the amount of amyloid present in macular amyloid is often very small and difficult to detect. We suggest that many cases of long-standing notalgia paraesthetica may result in the formation of amyloid, possibly secondary to chronic friction.

Aged↗
PubMed1988

Viral warts.

Explore the source record for details and available documents.

Child↗
PubMed1988

Bacteriology and antibiotic treatment of perineal suppurative hidradenitis.

A plausible bacterial pathogen (Streptococcus milleri, Staphylococcus aureus, anaerobic streptococcus, or Bacteroides species) was isolated at least once in 26 of 32 patients with active perineal suppurative hidradenitis. The main pathogen was S milleri, whose presence was significantly associated with disease activity and whose disappearance significantly correlated with clinical improvement; S aureus nd anaerobic streptococci were also implicated.

Adult↗
PubMed1982

Acrokeratoelastoidosis.

A case of acrokeratoelastoidosis (AKE) is reported. A review of the literature has established that at least three clinicopathological entities have been reported under this term. Two of the entities show a combination of hyperkeratosis with fragmentation of dermal elastic tissue, which justifies the designation AKE. The first, for which the term familial AKE is perhaps appropriate, though many cases have been sporadic, begins in childhood or early adult life, and there is no evidence that trauma or light exposure are factors in its production. The second is a more variable clinical syndrome occurring in middle or late adult life, and both physical trauma and light exposure appear to be concerned in its induction. The third syndrome to be reported under the designation AKE shows no abnormality of elastic tissue and appears to be a separate entity.

Child↗