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Biomedical subjects

A S David

Publications and source records attributed to A S David.

162 records · Page 9Linked to original sources

Voluntary movement dysfunction in Huntington's disease and tardive dyskinesia.

Psychiatric patients with tardive dyskinesia (TD) may be difficult to distinguish from those with Huntington's Disease (HD), who frequently have psychiatric symptoms. This study compared 14 patients with HD with 21 patients (15 schizophrenics and 6 with affective disorder), matched for involuntary movements, using a quantitated neurological examination and other objective and semi-objective tests. The HD group was significantly more impaired on measures of voluntary movement and saccadic eye movements. When the psychiatric group was subdivided, voluntary motor impairment was most marked in schizophrenics with both TD and parkinsonism. The implications of these findings are discussed.

Antipsychotic Agents↗

"On-off" phenomena and manic-depressive mood shifts: case report.

A patient with idiopathic Parkinson's disease and "on-off" phenomena is described. A consistent relationship existed between the "on" (dyskinetic) phases and mania and between the "off" (akinetic) phases and depression. The heuristic interest of this case and its indirect support of the dopamine hypothesis of affective disorder are discussed.

Adult↗

Hysterical paralysis following status epilepticus: case report and review of the concept.

A unique illness consisting largely of quadriplegia in an 18-year-old woman with neurogenic and psychogenic seizures is described and discussed in detail. The precise nature of the illness remains obscure, although it was predominantly hysterical. The concept of hysteria is reappraised and examined in terms of the mind-brain problem of philosophy.

Adolescent↗

Mutism following left hemisphere infarction.

A case of mutism due to left hemisphere infarction is described. Recovery revealed mild motor dysphasia. Review of the literature showed that the case resembles aphemia but is unique by virtue of its duration, and the absence of associated apraxia and paresis.

Aphasia↗

Successful pregnancy following haemodialysis and pyeloplasty.

A successful pregnancy in a patient who presented with renal failure secondary to pelvi-ureteric obstruction is described. Haemodialysis was instituted during the pregnancy. An Anderson-Hynes pyeloplasty was performed, probably preventing deterioration of remaining renal function. Metabolic acidosis was managed using additional bicarbonate in the dialysate. An active, multidisciplinary approach is recommended in the management of such patients.

Adult↗

Peripheral vein and fistula blood samples after single-needle dialysis.

It is traditional in renal units to check patients' biochemical parameters pre- and postdialysis. When a single-needle system is used, the blood is obtained through the arterial limb of the Y cannula, thus avoiding an extra venipuncture. The pre-sample is taken immediately after the cannula is inserted and the post-sample is taken after the blood lines have been disconnected and the venous limb clamped. It was the purpose of this investigation to determine whether the post-samples gave an accurate indication of the patient's electrolyte status. Samples taken from the arteriovenous fistula and those taken simultaneously from a peripheral vein in the opposite arm were compared. It is concluded that postdialysis concentrations should be determined from peripheral vein samples only.

Arteriovenous Shunt, Surgical↗

Visual imagery and depersonalisation.

Twenty-eight people diagnosed with depersonalisation disorder (DD) were assessed using self-report measures of imagery ability in relation to a range of symptoms and in comparison with age- and sex-matched controls. It was found that symptoms of depersonalisation as well as other dissociative symptoms and depressed mood correlated with impaired ability to generate visual images. This was particularly evident with images pertaining to the self and other people as opposed to objects. A subgroup of 10 patients was tested on a neuropsychological battery of visual perception tests and found to be unimpaired compared with normal controls and patients with obsessive compulsive disorder, despite subjective impairments in imagery and high symptom scores. The findings add further weight to the distinctions made between imagery and perceptual processes.

Adult↗

Illness and insight.

The term insight, when applied to illness, encompasses a patient's awareness and the personal significance of his/her disease, and the need for treatment. Insight is shaped by cultural, psychological and neurological factors. It affects attitudes to compliance and screening, levels of distress and may influence prognosis.

Attitude to Health↗

Insight and adherence to treatment in psychotic disorders.

Patients with psychotic disorders may benefit from strategies designed to improve their adherence to treatment. The assessment of relevant treatment and patient-related variables is an important consideration for the mental health professional.

Antipsychotic Agents↗