A S Chughtai | Search PubMed

PubMed2002

Methicillin resistant Staphylococcus aureus: a multicentre study.

OBJECTIVE: To determine the frequency of Methicillin resistance Staphylococcus aureus infection in major cities of Pakistan. SETTING: Various laboratories of the country with one as the central Laboratory. MATERIALS AND METHODS: Seven hundred and ninety two consecutive clinical isolates of Staphylococcus aureus were collected from 8 laboratories all over Pakistan i.e. Karachi, Peshawar, Lahore, Sukkhur, Islamabad, Quetta, and Mirpur, Azad Kashmir. Antibiotic sensitivity was done by Kirby Bauer disc diffusion method and MIC of Vancomycin was determined by 'E' test. RESULTS: Forty two percent of the isolates were found to be Methicillin resistant staphylococcus aureus (MRSA) while no Vancomycin resistance was encountered. CONCLUSION: Methicillin resistant Staphylococcus aureus (MRSA) are seen in the local population with frequencies varying between 2-61% highest incidence is seen in the major cities of the country. Fortunately no Vancomycin resistant Staphylococcus has been isolated from any of the major cities.

Developing Countries↗

PubMed1998

Primary intraosseous malignant peripheral nerve sheath tumor: a case report and review of the literature.

Primary intraosseous malignant peripheral nerve sheath tumors (MPNST) are exceptionally rare; the case reported here represents the first documented example occurring in the spinal column. The tumor arose in the second cervical vertebra of a forty year old woman of Asian origin. She had no stigmata of von Recklinghausen's disease (VRD). Plain radiographs and magnetic resonance imaging showed an osteolytic lesion within the expanded body of the vertebra. Histology revealed spindle-shaped tumor cells with nuclei showing pleomorphism, pallisading and mitotic activity. The cells stained positively for S-100 protein. The patient underwent stabilisation of the cervical spine and tumor excision as a two-stage procedure. She died of pulmonary metastases one year later. We have reviewed the literature on the pathology of these tumors.

Adult↗