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Biomedical subjects

A Ryman

Publications and source records attributed to A Ryman.

7 recordsLinked to original sources
PubMed1994

Randomised controlled trial in northern England of the effect of a person knowing their own serum cholesterol concentration.

SUBJECT OBJECTIVE: To test the hypotheses that the knowledge that the serum cholesterol concentration is raised (> or = 6.5 mmol/l) will lead to a reduction in the concentration after education intervention and that the knowledge that the concentration is not raised does not lead to an increase in the serum cholesterol concentration after education intervention. DESIGN: Prospective randomised trial, with investigators blind to the randomisation. SETTING: An industrial site in Manchester, England. PARTICIPANTS: A total of 495 employees of Imperial Chemical Industries, 469 of whom completed the trial. MAIN RESULT: There was a significant reduction in the serum cholesterol concentration of those whose initial concentration was > or = 6.5 mmol/l and who were given the result. This reduction was 0.28 mmol/l greater than in the control group. The reduction was similar, however, to the increase in the serum cholesterol concentration in those whose initial concentration was < 5.2 mmol/l, regardless of whether or not they had been given the result. CONCLUSION: These results support the hypotheses, although the lack of regression to the mean in the control group with high serum cholesterol suggests that this conclusion should be treated with caution.

Adult↗
PubMed1990

Electrophysiological properties of nigrothalamic neurons after 6-hydroxydopamine lesions in the rat.

Extracellular recordings were made from electrophysiologically identified nigrothalamic cells in the substantia nigra pars reticulata of anaesthetized rats. The firing rate, firing pattern and responses to striatal stimulation were investigated in normal animals and in animals in which dopamine concentration in the ipsilateral striatum was reduced by more than 90%. At relatively short times after the lesion (less than 10 days) the mean firing rate of the spontaneously active cells in the population was significantly reduced and there was an increase in the occurrence of bursting activity. There was also a significant increase in the number of silent cells, located by antidromic stimulation from the thalamus. In spite of this reduction in mean firing rate the responses of neurons to stimulation of either the ipsilateral striatum or ventromedial thalamus was much larger in cells from lesioned animals. At longer times after the lesion (more than six months) the average firing rate of the neurons had returned to normal but there was still a prevalence of bursting activity and a consequent reduction in mean inter-spike intervals. There was little evidence of the previous hyper-responsiveness to thalamic stimulation but the responsiveness to striatal stimulation was still significantly elevated.

Animals↗