Biomedical subjects
A Rydning
Publications and source records attributed to A Rydning.
Healing of benign gastric ulcer with low-dose antacids and fiber diet.
A randomized, double-blind, placebo-controlled trial was conducted to determine the efficacy of a low-dose aluminum-magnesium antacid regimen (Link one tablet q.i.d.) (total neutralizing capacity 120 mmol HCl/day) in combination with a high- or a low-fiber diet in ulcer healing and relief of symptoms in patients with benign gastric ulcer. After 6 wk, the ulcer healed in 28 (67%) of the 42 patients treated with antacids compared with 11 (25%) of the 44 patients treated with placebo (p less than 0.001). Antacids were also significantly more effective than placebo in the relief of symptoms. The dietary treatment did not significantly influence ulcer healing or ulcer symptoms. Constipation was more frequently seen with the low- than with the high-fiber diet (p less than 0.01). No significant side effects from antacids were recorded.
Dietary fiber and peptic ulcer.
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Dietary fiber and peptic ulcer. A review.
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Intragastric bile acid concentrations in healthy subjects and in patients with gastric and duodenal ulcer and the influence of fiber-enriched wheat bran in patients with gastric ulcer.
Fasting and postprandial intragastric bile acid concentrations were determined in healthy subjects and in patients with gastric and duodenal ulcer. The results showed great interindividual variation and wide overlapping between groups. Mean bile acid concentrations, fasting and postprandially, were significantly higher in patients with gastric ulcer than in healthy subjects. The differences between gastric and duodenal ulcer patients and between duodenal ulcer patients and healthy subjects were not significant. Fiber-enriched wheat bran reduced bile acid concentrations significantly in patients with gastric ulcer disease.
Fiber diet and antacids in the short-term treatment of duodenal ulcer.
Eighty patients with active duodenal ulcer were randomized to a diet poor or rich in fiber for a treatment period of 4 weeks. In addition, all patients received one antacid tablet (Link, 1.1 g) four times a day (total neutralizing capacity, 120 mmol HCl/day). The ulcer healed in 27 (67.5%) of the 40 patients in the high-fiber group, compared with in 24 (60%) of the 40 patients in the low-fiber group (p less than 0.5). Ulcer symptoms did not differ significantly between groups during the 4-week treatment period. No serious side effects were recorded. Constipation, the most frequently registered side effect, was seen in 11 (27.5%) of the patients in the low-fiber group, compared within 4 (10%) in the high-fiber group (chi-square = 4.0; p less than 0.05). Patients with unhealed ulcer after 4 weeks' treatment received ranitidine instead of antacids. While they were receiving ranitidine treatment, no significant differences in healing rates were seen between the two dietary groups.
The effect of guar gum and fiber-enriched wheat bran on gastric emptying of a semisolid meal in healthy subjects.
The effect of physiological doses of guar gum (Guarem), 5 g, and fiber-enriched wheat bran (Fiberform), 10.5 g, on gastric emptying was studied by two different methods in healthy subjects: by a simple isotope localization monitor placed over the upper part of the abdomen and by gamma camera. The fiber preparations were added to a semisolid meal consisting of wheatmeal porridge and juice, using technetium-99 DTPA as a marker. The gamma camera showed no effect of fiber on gastric emptying. The isotope localization monitor, however, indicated that Fiberform prevented a postprandial accumulation of the meal within the upper part of the stomach. The simple isotope localization monitor cannot be recommended for measurements of gastric emptying.
Dietary aspects of peptic ulcer disease.
Diets modify gastric function in various ways. Fibre influences acidity, pepsin and bile acid concentrations both in vitro and in vivo. Both animal studies and clinical studies in humans give reason to believe that a diet rich in fibre may protect against the development of peptic ulceration.
Influence of fiber on acidity, pepsin, and bile acids in human gastric juice in vitro.
The effect of a fiber-enriched wheat bran product, Fiberform, and a guar gum, Guarem, on gastric juice acidity, pepsin, and bile acid concentration was studied in vitro. Fiberform had a slight acid-binding capacity. The fiber preparation did not bind pepsin. Both products bound bile acids. With Fiberform the amount of bile acids bound was proportional to the amount of fiber and most pronounced at low pH and high bile acid concentration.
Influence of fiber on postprandial intragastric juice acidity, pepsin, and bile acids in healthy subjects.
The effect of a fiber-enriched wheat bran product, Fiberform, and a guar gum preparation, Guarem, on postprandial intragastric juice acidity and pepsin and bile acid concentrations was studied in healthy subjects. Fiber-enriched wheat bran prolonged significantly the meal-induced elevation of pH and decrease in pepsin. Both fiber products reduced postprandial intragastric bile acid concentration.
Treatment of gastric ulcer with ranitidine.
Forty-eight patients with endoscopically proven gastric ulcer were treated either with ranitidine tablets, 150 mg twice daily, or with placebo tablets under double-blind conditions. Three patients were for various reasons excluded from the study. After 6 weeks' treatment a second endoscopy was performed. The ulcer had healed in 22 (88%) of the 25 patients who had received ranitidine tablets and in 4 (20%) of the 20 patients who had received placebo tablets. The difference was statistically significant (p less than 0.002). The number of days and nights with pain attacks and the number of antacid tablets consumed were significantly (p less than 0.002) lower in the patient group treated with ranitidine. The 3 patients with non-healed ulcer after treatment with ranitidine had their ulcers healed after a further 6 weeks' treatment with ranitidine, and of the 16 patients with non-healed ulcer after treatment with placebo tablets, 13 had their ulcers healed after 6 weeks' open treatment with ranitidine, 150 mg twice daily. No serious side effects that could be ascribed to treatment occurred during the study.
Prophylactic effect of dietary fibre in duodenal ulcer disease.
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Relationship between ranitidine plasma levels and reduction of postprandial intragastric acidity in healthy man.
Intragastric acidity was measured for 20 min before and 6 h 40 min after a steak meal by aspiration of small aliquots of the gastric content every 10 min in 11 healty volunteers. Administration of ranitidine hydrochloride (100 mg) at the beginning of the meal reduced postprandial acidity markedly throughout the test, but there was no correlation between the percentage reduction of acidity and the concentration of ranitidine in plasma. The effect of the drug lasted much longer than would be expected from the plasma values. The results suggest that ranitidine is cleared more rapidly from the blood than from the H2-receptors of the parietal cells, and the reduction of postprandial acidity by ranitidine cannot be deduced from the plasma values of the drug.
Controlled clinical trial of duodenal ulcer healing with antacid tablets.
The effect of an antacid tablet regimen (total acid-neutralizing capacity, 280 mmol/day) and placebo was studied in 75 patients with duodenal ulcer in a double-blind 4-week trial. The ulcer healed in 30 out of 37 (81%) patients treated with antacids as compared with 9 out of 38 (24%) patients treated with placebo (p less than 0.001). Ulcer symptoms in the antacid- and the placebo-treated groups did not differ significantly until the last week of treatment (p less than 0.01). Both constipation and diarrhoea were slightly more common in antacid- than in placebo-treated patients (NS). Serum concentration of aluminium increased significantly (p = 0.01), whereas serum concentrations of calcium, phosphorus, magnesium, iron, and total iron-binding capacity did not change during treatment. No other side effects of antacids were recorded. Thirty-eight patients with unhealed ulcer after cessation of the antacid/placebo treatment were treated openly with 150 mg ranitidine twice daily. The ulcer healed in 31 out of 37 (83%) patients (one drop-out) after 4 weeks' treatment, and only one patient remained with unhealed ulcer after 6 weeks' ranitidine treatment. No side effects due to ranitidine were recorded.
Antibiotic-associated pseudomembranous colitis. A case report.
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Reduction of postprandial gastric acidity and pepsin concentration by ranitidine and antacids in healthy volunteers.
Small aliquots of gastric content were withdrawn every tenth minute for 7 h in 11 healthy volunteers with a maximal gastric acid output of more than 20 mmol h-1. After 20 min a steak meal was given. Ranitidine hydrochloride 100 mg administered with the meal increased postprandial gastric pH and reduced acid concentration markedly throughout the test. Two tablets of antacids with a neutralizing capacity of approximately 20 mmol per tablet 1 and 3 h after the meal reduced gastric acidity significantly less than ranitidine and did not prevent an increase in acidity to control level during the interval between the two doses. In the control experiments 40% of the pH readings during the 4 postprandial hours were at or above the pre-prandial pH levels. Antacids and ranitidine increased this to 85% and 96% respectively. Antacids had no effect after the fourth postprandial hour, had very little effect when given in addition to ranitidine, but reduced the mean four hour postprandial pepsin concentration more than ranitidine.
Carnitine levels in human serum in health and disease.
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[Norweigan military dentistry during last 30 years (1942-1972)].
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