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Biomedical subjects

A Ryan

Publications and source records attributed to A Ryan.

At least 145 records · Page 8Linked to original sources
PubMed1976

The goat mammary gland as a model infection site for Neisseria gonorrhoeae.

Live and formalin-killed gonococci were instilled into the mammary glands of lactating and nonlactating goats. In lactating goats viable gonococci elicited a limited inflammatory process whereas in non-lactating goats, severe inflammation and swelling appeared and peaked on the 3rd day after instillation and persisted for about 10 days. No viable gonococci were recovered after the first day, but fluorescent antibody staining showed gonococci in the exudate from non-lactating goats up to 7 days after instillation.

Animals↗
PubMed1976

Antibody production in milk serum of goats experimentally infected with Neisseria gonorrhoeae.

Instillation of the goat's mammary gland with Neisseria gonorrhoeae colony type T1 has elicited and antibody response in the goat milk serum (GMS). Purification, and characterization of the GMS by gel filtration, electrophoresis, immunodiffusion, analytical ultracentrifugation, and serological analyses demonstrated thtat the active immune component was mainly in the IgA and IgG fractions (F2 and F3) of GMS.

Animals↗
PubMed1975

A mouse intracerebral infection with Neisseria gonorrhoeae.

An intracerebral challenge of HPB black mice with Neisseria gonorrhoeae is described. In this mode, the mice died from 1 to 6 days after challenge, and T1 organisms were obtained up to the fifth day from brain, liver, kidney, and spleen. Experimental gonococcal vaccines gave good protection against the challenge.

Animals↗
PubMed1975

The chick embryo in studies of virulence and immunity with Neisseria Gonorrhoeae.

Intravenous inoculation of 11-day old chick embryos with Neisseria gonorrhoeae has confirmed the original observation of Bumgarner and Finkelstein that T1 and T2 gonocci are significantly more virulent than T3 and T4. Pili do not seem to be solely responsible for this virulence, since elimination of pili did not effect either the viability or the virulence of N. gonorrhoeae. In neutralization studies, there was only one log difference between the ability of normal and hyperimmune rabbit serum to protect the embryo against gonoccocal infection. However, when mouse sera were used in the same chick embryo system a clear difference was noted between the protective activity of normal serum and that antisera elicited in mice by purified gonococcal antigens. It is suggested therefore that mouse antisera be used in this chick embryo model for the assay for gonococcal antigens.

Animals↗
PubMed1972

Single cell activity in the auditory cortex of Rhesus monkeys: behavioral dependency.

The response to repetitive stimulation of single cells in the auditory cortex of the monkey is dependent upon behavioral performance and training of the subject in a simple auditory discrimination task. In the trained, performing animal, single cells are more responsive than in the animal that is trained but not performing in the task. In the naive monkey, evoked responses are labile and are maintained only with nonrepetitive auditory stimuli.

Acoustic Stimulation↗