[Phase I study of a tolmetin-paracetamol (AU-8001) ester].
A cross-over study of a tolmetin-paracetamol ester was performed on 6 healthy females. The low biodisponibility obtained might preclude its therapeutic use.
Acetaminophen↗
Biomedical subjects
A Rubio
Publications and source records attributed to A Rubio.
[Pharmacologic surveillance outside the hospital: necessity and methods].
Explore the source record for details and available documents.
Drug Information Services↗
[Laryngeal reinnervation: transposition of neuromuscular pedicles].
Following Tucker's technique, a muscle-nerve pedicle implantation in the denervated posterior cricoarytenoid muscle was performed in five dogs. Results were evaluated after six months by videolaryngoscopy, evoked muscle action potentials and histomorphometric studies. Partial motion recovery of the reinnervated side was observed endoscopically in three dogs. Histomorphometric evaluation showed evidence of muscle reinnervation in all of the five dogs. However, no muscle action potentials were obtained in the posterior cricoarytenoid muscles after stimulation of the ansa hypoglossi branch. These data suggest that the ansa hypoglossi neuromuscular pedicle does not result in reinnervation, and that reinnervation of the posterior cricoarytenoid muscle may occur via other neuromuscular pathways.
Animals↗
Rhodococcus equi: first case in a heart transplant recipient.
Rhodococcus equi is a gram-positive diphtheroid that occasionally affects immunocompromised patients, usually causing a chronic respiratory infection with cavitating pulmonary opacities on chest radiograph that resemble mycobacterial or fungal disease. Etiologic diagnosis presents a number of pitfalls, because Rhodococcus equi isolates mimic many of the characteristics of other microorganisms more familiar to the laboratory staff. The treatment of choice for this disease has not yet been established, and its mortality rate is greater than 50% in individuals with human immunodeficiency virus and 20% to 25% among the remaining patients. We describe here the first case of Rhodococcus equi infection in a heart transplant recipient. Clinical presentation was typical, and treatment with a sensitivity-based combination of antibiotics resulted in resolution of both the clinical and radiologic picture.
Adult↗
What providers should know about community cancer control.
PURPOSE: The authors describe a framework for developing an effective, community-focused cancer control program. OVERVIEW: Progress in the application of cancer control interventions has proven to be quite variable across different populations and communities. The Kentucky Cancer Program, developed under joint sponsorship of cancer centers at two state universities, has been using a model that appears to provide a high degree of sensitivity to community-specific problems and solutions. The Kentucky four-step model includes 1) using data from a population-based cancer registry and other sources to identify problems; 2) ensuring community involvement with providers in selecting the target population and developing the intervention strategy; 3) implementing the intervention plan; and 4) using cancer registry and other data to evaluate the impact of this intervention. CLINICAL IMPLICATIONS: This framework may be useful to providers as they try to balance the goals of their clinical practice and the goals of community cancer control. Developing an effective, community-focused cancer control program requires that providers gain a solid knowledge about their community. The depth and richness of that knowledge base is enhanced by the active participation of community members as they collaborate with the providers on planning and implementing cancer control activities.
Breast Neoplasms↗
Cervical spinal meningioma with unusual MR contrast enhancement.
A 16-year-old girl had progressive neck pain and weakness in the left hand. MR images showed a dumbbell-shaped spinal tumor with a prominently enhancing intradural component and a minimally enhancing extradural component. Pathologic examination revealed a meningioma with an intradural transitional component and an extradural syncytial component. The tumor showed no significant cystic change or necrosis.
Adolescent↗