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Biomedical subjects

A Rubinstein

Publications and source records attributed to A Rubinstein.

At least 289 records · Page 16Linked to original sources
PubMed1976

Possible effect of maternal promethazine therapy on neonatal immunologic functions.

The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

Antibodies↗
PubMed1976

Autologous marrow reconstitutions in severe aplastic anaemia after ALG pretreatment and HL-A semi-incompatible bone marrow cell transfusion.

Three consecutive patients considered to have end-stage acquired aplastic anaemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 x 10(8) nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC-positive family donors. All patients showed autologous marrow reconstitutions lasting now 2-3 1/2 years. No clear-cut evidence of marrow engraftment could be established and no graft-versus-host disease was seen. It is assumed that these patients had some normal pluripotent haemopoetic stem cells which proved to be able of endoreduplication and of going into cycle after ALG conditioning and allogeneic marrow transfusion.

Adult↗
PubMed1976

Allogeneic iliac transplants in rhesus monkeys. A sequential histologic study.

Fresh and frozen allogeneic iliac grafts were used in surgically prepared intraosseous defects. Four adult rhesus monkeys provided 19 specimens from 0 to 56 days postoperative. There were 8 specimens for each type of graft and 3 others used as controls. Histologic sections from each specimen were prepared and a description of the sequential healing events was given. The similarities and differences in repair were discussed. The advantages and disadvantages of each technique were analyzed and insight into their clinical applications was provided. No significant difference was observed in the sequential healing of the fresh and frozen allogeneic bone grafts, and both allografts induced a more rapid osseous regeneration than the controls. The fresh and frozen allogeneic transplants were accepted by the host as was evidenced by the involucrum formations.

Alveolar Process↗
PubMed1976

Immunological decay in thymectomized infants.

Four infants underwent radical thymectomy for a suspected malignancy of the thymus. Histology revealed no malignant cells. The patients did clinically well as long as 14 years after the operation. There was laboratory evidence for a cellular and humoral immunodeficiency. Affected were mainly the response to oral poliomyelitis vaccinations and the skin tests of delayed type hypersensitivity.

Adolescent↗
PubMed1975

Bone marrow transplantation in combined immunodeficiencies.

Correction of combined immunodeficiences was attempted in 4 patients. Attainment of lasting immunologic reconstitution was restricted to an HL-A identical graft. However, HL-A identity was not a safeguard against graft-vs-host reaction (GVHR). Failure of donor-host adaptation resulted in chronic GVHR. In unmatched grafts, alloimmune plasma was capable of only transient amelioration of GVHR. Alloimmune plasma prevented fatal GVHR in one patient receiving a HL-A semiidentical graft. However, no direct evidence for a T-cell engraftment was shown. The failure to prevent GVHR or to reverse an ongoing reaction in incompatible bone marrow transplantations demands a reappraisal of the conceptual approach to immunologic tolerance.

ABO Blood-Group System↗