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Biomedical subjects

A Rozanski

Publications and source records attributed to A Rozanski.

At least 37 records · Page 2Linked to original sources
PubMed1995

Using gated technetium-99m-sestamibi SPECT to characterize fixed myocardial defects as infarct or artifact.

UNLABELLED: Perfusion-scan fixed defects may result from soft tissue attenuation, decreasing test specificity for coronary disease and myocardial infarction (MI). Gated 99mTc-sestamibi SPECT may help differentiate MI from artifact since fixed defects with decreased function (wall motion and thickening) probably represent MI, whereas attenuation artifacts either have normal function or at least do not demonstrate markedly reduced function. METHODS: Ungated resting and gated stress 99mTc-sestamibi SPECT was performed in 551 consecutive patients referred for evaluation of coronary disease. From resting and summed gated stress images, 180 patients (33%) were identified with isolated fixed defects. Function of the defects was assessed subjectively from gated stress images and results were correlated with clinical (history and/or ECG Q-waves) evidence of MI. RESULTS: Of 102 patients with fixed defects and clinical MI, 98 (96%) had abnormal defect function. Of 78 patients with no clinical MI, 18 (23%) had decreased function of the defect, possibly indicating silent MI. In 60 of the 78 patients (77%) with no clinical MI, defect function was normal. Because most (91%) of fixed defects with normal systolic function occurred in women with anterior fixed defects (48%) or men with inferior fixed defects (43%), these were most likely attenuation artifacts. By reclassifying patients with fixed defects and normal function as normal, patients with unexplained fixed defects (no clinical MI) decreased from 14% to 3%. CONCLUSION: Gating provides a valuable adjunct to 99mTc-sestamibi SPECT in characterizing fixed defects and potentially improving test specificity.

Artifacts↗
PubMed1994

Triggers of angina and ST-segment depression in ambulatory patients with coronary artery disease: evidence for an uncoupling of angina and ischemia.

This study evaluated daily-life physical and mental triggers of painful and painless myocardial ischemia and of anginal pain in patients with coronary artery disease (CAD) by using ambulatory electrocardiographic monitoring and a structured diary. Eighty-five percent of ambulant ischemic episodes occurred without chest pain; 66% of anginal pain reports were made in the absence of ischemic ST-segment depression. Chest pain reports in the absence of ischemia could not be attributed to "borderline" ST-segment changes. Compared with silent ischemia, painful ischemia was triggered at higher levels of physical activity (p < 0.05) and at higher levels of self-rated effort and negative emotion (p < 0.05). Painful episodes were associated with greater-magnitude ST depression (p < 0.02), but a substantial percentage of episodes with > or = 2 mm and > or = 3 mm ST depression were silent. These results reveal an uncoupling of anginal symptoms from ambulatory ischemic episodes in patients with CAD during daily life. In addition, specific activities and emotions correlate with the presence or absence of anginal symptoms as much as does the presence of ischemic ST depression. These results may have implications for antiischemic and antianginal treatment strategies.

Activities of Daily Living↗
PubMed1994

Pathophysiologic factors governing the variability of ischemic responses to treadmill and bicycle exercise.

Ischemic responses may vary considerably when patients with coronary artery disease (CAD) are tested serially, but the pathophysiologic mechanisms that govern this variability have not been well evaluated. We thus evaluated whether clinical, hemodynamic, physiologic, and anatomic factors influenced the variability in ischemic responses among 140 patients (mean age 54 +/- 11 years) subjected to both bicycle and treadmill exercise electrocardiography. Radionuclide ventriculography was obtained during bicycle exercise in each patient. The population included 77 patients with CAD, 21 patients with normal coronary arteriograms, and 42 patients with < 5% likelihood of CAD. Bicycle exercise evoked higher systolic blood pressure (p < 0.001) and double-product (p < 0.001) responses compared with treadmill exercise in the patients with CAD and in the normal subjects, and it evoked a lower frequency of chest pain (12% vs 41%, p < 0.001) in the 34 patients with CAD who had ST-segment depression during both exercise tests. There was a high frequency of variability in ischemic responses during treadmill versus bicycle exercise: 22 (39%) of the 56 CAD patients who had exercise-induced ST-segment depression manifested this response during one stress test only. This variability was strongly related to the functional and anatomic magnitude of disease. Ischemic variability decreased progressively as the response of left ventricular ejection fraction (LVEF) to exercise worsened progressively (p = 0.003 by analysis of variance), from 83% in those with an LVEF increase of > 10% with exercise to only 13% in those with an LVEF fall of > or = 5% with exercise.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Angiography↗
PubMed1994

Induction of silent myocardial ischemia with mental stress testing: relation to the triggers of ischemia during daily life activities and to ischemic functional severity.

OBJECTIVES: This study examined the relations among the triggers of ischemia during the activities of daily life, mental stress-induced ischemia in the laboratory and functional severity of ischemia on exercise testing. BACKGROUND: Myocardial ischemia is readily induced with exercise testing, but most episodes of ischemia in daily life occur during relatively sedentary activities. Although mental and emotional arousal are known to trigger myocardial ischemia, mental stress testing induces ischemia in only approximately 50% of patients with active coronary disease. It is not known whether such patients are particularly susceptible to nonexertional ischemia during daily activity. METHODS: We studied 45 men (mean age +/- SD 58 +/- 9 years) with coronary artery disease by means of 48-h Holter ambulatory electrocardiography for ST segment analysis and quantification of physical and mental activity with a structured diary system. These data were cross-tabulated with new left ventricular dyssynchrony (detected on two-dimensional echocardiography) induced by two mental stressors and by bicycle exercise. RESULTS: During mental stress testing, 24 patients (53%) (Group I) had a new wall motion abnormality; the other 21 patients (Group II) did not. The average wall motion dyssynchrony score increased from 1.20 +/- 0.29 to 1.34 +/- 0.36 (p = 0.001), but the increase was less than that with exercise stress (1.52 +/- 0.41, p = 0.001). The total duration of ischemia during sedentary activities was greater in Group I (22.9 +/- 24.5 min) than in Group II (3.6 +/- 3.9 min, p = 0.025). Group I had more ischemic events while sedentary (23 of 290 diary entries) than did Group II (8 of 256 diary entries, p = 0.015). The magnitude of dyssynchrony with mental stress and the number of mental stressors capable of triggering ischemia were related to severity of ischemia with exercise. CONCLUSIONS: Patients with ischemia during mental stress testing also have increased ischemia during sedentary activities in daily life. This finding may reflect greater functional severity of coronary artery disease or a propensity toward coronary vasoconstriction while sedentary.

Activities of Daily Living↗
PubMed1994

Is 'silent' myocardial ischemia really as severe as symptomatic ischemia? The analytical effect of patient selection biases.

BACKGROUND: The clinical significance of exercise-induced chest pain remains controversial, as reflected by sharply discordant clinical results within the medical literature. Thus, we developed a prospective study to compare the functional significance of silent versus symptomatic ischemia and to evaluate whether patient selection biases influence this analysis. METHODS AND RESULTS: We evaluated 117 patients (mean age, 63 +/- 9 years) with ischemic ST-segment depression during treadmill testing. Each patient underwent Tl-201 myocardial perfusion single-photon emission computed tomography (SPECT) after exercise followed by 24-ambulatory ECG monitoring. Patients were divided into silent versus symptomatic cohorts and were compared for the degree of hemodynamic, exercise and ambulatory ECG, and thallium abnormalities during stress testing. Analyses were repeated as the patient population became increasingly restricted. Compared with the silent patients, patients with chest pain during exercise had a shorter exercise duration (P < .009), lower peak heart rate (P = .009) and double product (P = .005), lower heart rate threshold for ST depression (P < .05), more episodes of ambulatory ST-segment depression (P < .05), a higher frequency of ischemia abnormalities during Tl-201 SPECT (P = .02), and higher summed Tl reversibility scores (P = .002). As the population became increasingly restricted, the relative magnitude of differences in silent versus symptomatic cohorts diminished, whereas the absolute magnitude of ischemic abnormalities progressively increased in both cohorts. For example, within the restricted group having ischemia on both exercise and ambulatory ECG, 50% of the silent cohort had severe ischemia on Tl SPECT (five or more reversible defects) and more than one third demonstrated the ominous finding of transient left ventricular dilation after exercise. CONCLUSIONS: The induction of chest pain is associated with substantially more functional abnormalities when it is analyzed in a relatively "broad-spectrum" coronary artery disease population; by contrast, chest pain tends to lose its apparent value as a clinical test parameter when its analysis is restricted to coronary artery disease populations with a greater a priori likelihood of manifesting inducible ischemia. These findings may help resolve some of the previous discordant literature reports.

Angina Pectoris↗
PubMed1993

Prevalence and functional significance of transient ST-segment depression during daily life activity: comparisons of ambulatory ECG with stress redistribution thallium 201 single-photon emission computed tomographic imaging.

To assess the prevalence and functional significance of ischemic ambulatory ECG responses, we prospectively performed ambulatory ECG monitoring in 244 patients (mean age 61 +/- 10 years) referred for stress redistribution thallium 201 myocardial perfusion scintigraphy. The prevalence of ST-segment depression during ambulatory ECG was 33% among patients with a positive exercise ECG, but prevalence varied in selected patient subgroups. Among three groups with coronary artery disease (CAD), the group with ambulatory ECG ischemia (group 1) had a greater frequency of ischemic thallium responses (p = 0.07), a greater median number of reversible thallium defects (p < 0.05), and a greater summed thallium "reversibility" score (p < 0.05) than did the group with a positive exercise ECG but negative ambulatory ECG response (group 2) or that with negative exercise and ambulatory ECG responses (group 3). Exercise ST depression in group 1 versus group 2 was significantly greater (p = 0.002), occurred at a lower heart rate threshold (p = 0.002), and lasted longer after exercise (p = 0.001). Notably, one third of group 1 patients also manifested evidence of transient ischemic dilation of the left ventricle after exercise (p < 0.01 vs groups 2 and 3), a sign of severe ischemia. However, although functionally less "sick" than group 1 patients, 66% of group 2 patients and 50% of group 3 patients still had an ischemic thallium response, which was sometimes severe. Thus transient ischemia during ambulatory ECG monitoring identifies a functionally sicker cohort of patients with CAD and occurs in approximately one third of CAD patients with positive results of exercise tests. A negative ambulatory ECG response, however, does not exclude functionally significant disease among CAD patients. These results imply that caution should be applied in the interpretation of a negative ambulatory ECG response for the purpose of patient risk stratification.

Activities of Daily Living↗
PubMed1993

Mental stress and myocardial ischemia. Correlates and potential interventions.

In past years, indirect evidence has suggested a link between mental stress and coronary artery disease. Recent research in coronary artery disease patients has confirmed the observation that mental stress is a potent trigger of myocardial ischemia in both the laboratory and the field. The pathophysiologic effects of mental stress appear to operate via alterations in both myocardial oxygen demand and supply. Intense negative emotion, such as hostility, and heightened cardiovascular reactivity are positively associated with this ischemia, suggesting that recognition of these factors may help identify patient subgroups at highest risk. Preliminary studies evaluating pharmacologic intervention suggest that traditional anti-ischemia therapy, such as beta-blockers and vasodilators, can reduce mental-stress-triggered ischemia in coronary artery disease patients. Behavioral and psychosocial interventions, such as reducing environmental stress through social support, altering stress perception through behavioral training, and altering the physiologic reaction to stress through physical training, also show promise as therapeutic options. Further work is needed in this fertile biobehavioral area.

Hemodynamics↗
PubMed1993

Effect of motion on thallium-201 SPECT studies: a simulation and clinical study.

Although patient motion on 201Tl SPECT studies has been reported as a source of artifacts, systematic studies on motion patterns and resultant artifacts are lacking. Accordingly, we simulated 74 motion patterns upon a normal study. The tomograms were assessed for presence of defects: The "motion pixel area index" ranged from 1 to 83; 26 of 30 (87%) simulations with an index > or = 21 had defects, whereas 38 of 44 (86%) simulations with an index < 21 were normal. Defect location was dependent on motion direction; defect intensity was dependent on its magnitude and timing. Review of data acquisition in 164 recent normal patient studies revealed motion in 42 (26%). Motion was generally minimal and caused defects in only seven (4%). Thus, mild motion is unlikely to produce defects. In our laboratory, motion is now an infrequent source of artifacts; severe motion produces recognizable patterns that depend on its direction, magnitude and timing.

Adult↗
PubMed1992

Reproducibility of stress redistribution thallium-201 SPECT quantitative indexes of hypoperfused myocardium secondary to coronary artery disease.

To determine the reproducibility of quantitative indexes of hypoperfused myocardium by exercise thallium-201 single-photon emission computed tomography, duplicate studies were performed in 16 stable patients within 1 month. Twenty-three other patients, with intervals up to 13 months between studies, were retrospectively identified from medical records. Symptoms, weight, heart rate achieved and peak systolic blood pressure during the 2 studies were similar. Maximal counts circumferential profiles' polar maps were generated and divided into 3 vascular territories. The hypoperfused myocardium was defined as the percent stress profile points below the normal level. The observed values were compared between the 2 studies for each patient. Defect size ranged from 0 to 73%. The concordance correlation coefficient (a measure of the closeness of the data points to the line of identity) and mean absolute deviation were 0.94 and 4.5%, respectively, when all patients were considered together, 0.93 and 3.2%, respectively in the reproducibility group, and 0.94 and 5.1%, respectively, in the retrospective group. Inter- and intraobserver reproducibility were also very high. For individual vessels, the concordance correlation coefficients were all > or = 0.89 and the mean absolute deviations between 3.7 and 9%. Thus, in stable patients with repeat thallium studies within a year, the percent hypoperfused myocardium is highly reproducible.

Adult↗
PubMed1991

Pharmacological and other nonexercise alternatives to exercise testing to evaluate myocardial perfusion and left ventricular function with radionuclides.

Pharmacological vasodilatation with either dipyridamole or adenosine is a safe and accurate alternative to exercise testing to diagnose coronary artery disease with thallium 201 myocardial perfusion imaging. The technique also provides important prognostic information with regard to future cardiac events in patients undergoing diagnostic testing, in those evaluated preoperatively, and in those with recent myocardial infarctions. Multigated equilibrium and first-pass radionuclide ventriculography also are well suited to evaluate the effects of interventional procedures. Success has been achieved using this methodology in a variety of interventions including conventional exercise testing, pharmacological stress testing, atrial pacing, assessment of myocardial viability with nitroglycerin, mental stress testing, and ambulatory monitoring of left ventricular ejection fraction.

Adenosine↗
PubMed1991

Effect of beta-blockade on low heart rate-related ischemia during mental stress.

To explore the effect of beta-adrenergic blockade on low heart rate-related (mental stress) ischemia, 19 patients with coronary artery disease were randomized into a double-blind crossover trial of metoprolol, 100 mg twice daily, and underwent serial mental stress/bicycle exercise studies. Mental stress-induced wall motion abnormalities occurred at a lower heart rate than exercise-induced wall motion abnormalities during placebo administration (81 +/- 16 vs. 123 +/- 20 beats/min, p less than 0.05). Metoprolol reduced the mean magnitude of exercise-induced wall motion abnormalities (2.8 +/- 2.0 vs. 1.6 +/- 2.4, p = 0.003); improvement was related to the magnitude of hemodynamic beta-blockade effect. Metoprolol did not significantly reduce the mean magnitude of mental stress-induced wall motion abnormalities (3.0 +/- 2.2 vs. 2.6 +/- 2.2), although individual responses predominantly either improved (50%) or worsened (29%). Unlike exercise, the magnitude of hemodynamic beta-blockade did not predict mental stress response and metoprolol did not block mental stress-induced blood pressure elevations. Patients with abolition of exercise-induced ischemia were more likely to have reduction of mental stress-induced ischemia. Patients whose ischemia worsened with metoprolol during mental stress had more easily inducible ischemia, as assessed by exercise-induced placebo wall motion abnormality, chest pain and prior myocardial infarction. Beta-blockade was associated with a lowering of ischemia-related hemodynamic thresholds compared with placebo. These results suggest that beta-blockade has a variable effect on low heart rate-related ischemia that may be due to a lack of effect on mental stress-induced blood pressure elevation in patients with easily induced ischemia or to effects on coronary vasomotor tone, or both.

Adrenergic beta-Antagonists↗
PubMed1991

Ventricular responses to mental stress testing in patients with coronary artery disease. Pathophysiological implications.

Recent research examining the effects of mental stress on left ventricular wall motion and/or ejection fraction has used four techniques to measure contractile function: radionuclide ventriculography, a stationary nuclear probe, two-dimensional echocardiography, and an ambulatory radionuclide left ventricular function monitor. This research has consistently revealed that mental stress-induced myocardial ischemia occurs frequently during laboratory stress testing, particularly among patients with exercise-induced ischemia. This ischemia is usually silent, occurs at low heart rate elevations but with significant blood pressure increases compared with exercise-induced ischemia, and is frequently not detected when electrocardiographic markers are used alone. Exploration of factors underlying differences between mental stress- and exercise-induced ischemia has provided a means for studying the complex pathophysiology of myocardial ischemia.

Coronary Disease↗
PubMed1991

Accuracy and reproducibility of left ventricular ejection fraction measurements using an ambulatory radionuclide left ventricular function monitor.

The accuracy and reproducibility of a new ambulatory radionuclide detector system (the VEST) for ejection fraction measurement has not been fully validated. Thirty-six subjects, (19 volunteers and 17 patients) underwent repetitive bicycle exercise using sequences of both VEST monitoring and gamma camera imaging. A high intraclass correlation was noted for both absolute ejection fraction [0.84 (0.56, 0.95)] and delta ejection fraction [0.87 (0.63, 0.96)] during repeat VEST monitoring. The intraclass correlation for ejection fraction was comparable for data averaged over 30 sec versus 2 min. These correlations compared favorably to those obtained for assessment of absolute and delta ejection fraction as derived by gamma camera determination by the same computer operator (intraobserver variability), two different computer operators (interobserver variability), and during repeat exercise using gamma camera imaging. In concordance, correlations between VEST and gamma camera measurements were relatively high for both absolute ejection fraction (0.78 [0.61, 0.88]) and delta ejection fraction (0.63 [0.39, 0.79]). Thus, the VEST represents a reproducible means of measuring ejection fraction change during dynamic physical activity. Its accuracy in ejection fraction measurements is similar to gamma camera imaging during exercise testing.

Adult↗
PubMed1990

Mental stress as an acute trigger of ischemic left ventricular dysfunction and blood pressure elevation in coronary artery disease.

Acute mental stress may be a frequent trigger of transient myocardial ischemia, myocardial infarction and sudden cardiac death. In an experimental setting, the effect of mental stress on hemodynamics and left ventricular wall motion abnormalities (as detected by radionuclide ventriculography) was measured in 29 patients with exercise-induced myocardial ischemia. Seventy-five percent of the patients demonstrated mental stress-induced wall motion abnormalities. Patients frequently exhibited greater increases in peak systolic arterial pressure during mental stress than during exercise. Personally relevant mental stress is the most potent type of mental stress, both in terms of frequency and magnitude of ischemia. Most mental stress-induced ischemic episodes are clinically and electrocardiographically silent and occur at heart rates significantly lower than those seen during exercise. Both systolic and diastolic blood pressure increased during mental stress-induced ischemia, suggesting that increased myocardial oxygen demand plays a role in the pathophysiology of mental stress-induced transient ischemia. The significant magnitude and acute onset of this mental stress-induced blood pressure elevation may in some manner contribute to atherosclerotic plaque rupture. These findings may provide a pathophysiologic link to the epidemiologic association between mental stress and acute ischemic coronary events. A new ambulatory radionuclide detector that can concurrently monitor left ventricular ejection fraction and electrocardiographic ST-segment change may enhance the detection and evaluation of transient myocardial ischemia in ambulatory coronary patients.

Angina Pectoris↗
PubMed1990

The frequency of late reversibility in SPECT thallium-201 stress-redistribution studies.

The frequency of thallium-201 late reversibility was prospectively assessed in 118 patients who had stress-redistribution thallium-201 studies by single photon emission computed tomography (SPECT). These patients demonstrated two or more segments with nonreversible defects at 4 h imaging and underwent late (18 to 72 h) redistribution imaging. When the criterion of late reversibility was defined as greater than or equal to 1 segment with 4 h nonreversible defects demonstrating late reversibility, it was present in 62 (53%) of the 118 patients and 164 (22%) of 762 segments. When the criterion of greater than or equal to 2 segments was used, late reversibility was found in 41 (35%) of 118 patients and 143 (19%) of 762 segments. The frequency of detected reversible defects increased from 27% at 4 h imaging to 43% at combined 4 h and late imaging (p less than 0.0001) and was significantly increased in all myocardial regions. In comparing the efficacy of initial and late imaging alone versus performing initial, 4 h and late imaging for the identification of reversible defects, 421 (94%) of 449 segments classified as reversible by the latter protocol were also correctly identified by the early and late imaging only approach, with the remaining 6% (28 segments) comprising those segments demonstrating the reversible pattern at 4 h and the nonreversible pattern at late imaging. No major differences were noted with respect to clinical, stress electrocardiographic and scintigraphic variables between the 118 patients undergoing late imaging and 98 additional randomly selected patients with two or more nonreversible defects at 4 h, who did not have late imaging.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗