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Biomedical subjects

A Roy

Publications and source records attributed to A Roy.

At least 577 records · Page 32Linked to original sources
PubMedDate not supplied

Duplication of the upper lip and maxilla.

We report a patient with duplication of the upper lip and maxilla. This deformity is extremely rare and six previous reports are reviewed.

Abnormalities, Multiple↗
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Excess of depressive symptoms and life events among diabetics.

We compared a group of insulin-dependent diabetic outpatients with normal control subjects for their scores on the Beck Depression Inventory (BDI) and for their experience of recent life events. Diabetic patients had significantly higher BDI scores than controls and had experienced significantly more life events during the previous 6 months. These results suggest that psychiatric symptoms and social problems are common among insulin-dependent diabetics. Longitudinal studies of psychiatric disorder among diabetic patients appear to be indicated.

Adult↗
PubMedDate not supplied

Family history of suicide in manic-depressive patients.

Among 231 manic-depressive patients, 18 (7.8%) had a first- or second-degree relative who had committed suicide. There were no significant differences between the unipolar or bipolar patients for a family history of suicide. The literature is reviewed and the possible implications discussed.

Adult↗
PubMedDate not supplied

Pre- and post-dexamethasone plasma ACTH levels in depressed patients and normal controls.

Levels of plasma ACTH in relation to dexamethasone administration were evaluated in 16 medication-free patients with a major depressive episode and 39 normal controls. Depressed patients had significantly higher levels of plasma ACTH than controls both at 4:00 p.m. predexamethasone and 4:00 p.m. postdexamethasone. The significance of this finding is discussed.

Adrenocorticotropic Hormone↗
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Cortisol nonsuppression in depression: relationship to clinical variables.

The dexamethasone suppression test was performed in 63 depressed patients and 43 normal controls. Cortisol nonsuppression was found in 47.6% of the depressed patients and 4.6% of the controls. Among depressed patients both age and reported weight loss, but not severity of depression, were significantly related to postdexamethasone plasma cortisol levels. Patients who were cortisol suppressors had experienced significantly more life events before the onset of depression and had significantly higher hostility scores on a personality questionnaire than cortisol nonsuppressors.

Adult↗
PubMedDate not supplied

Plasma HVA levels in depressed patients and controls.

Plasma levels of the dopamine metabolite homovanillic acid (HVA) were examined in depressed patients and controls. There were no significant differences between the groups. In particular, there were no significant differences for plasma HVA levels between depressed patients with and without melancholia or between depressed patients who were cortisol nonsuppressors or suppressors.

Adult↗
PubMedDate not supplied

Dysregulation of the hypothalamo-pituitary-adrenal axis and duration of diabetes.

We compared insulin-dependent diabetic outpatients with and without retinopathy for plasma indices of hypothalamo-pituitary-adrenal (HPA) axis activity. Diabetic patients with moderate-to-severe retinopathy had significantly higher postdexamethasone plasma levels of adrenocorticotropic hormone than patients with minimal or no retinopathy. However, when duration of diabetes was taken into account this difference was no longer significant. These data suggest that dysregulation of the HPA axis and retinal microvascular complications found in diabetic patients may both be a function of duration of diabetes.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

Seasonal pattern of posttraumatic stress disorder admissions.

Seasonal influences in some psychiatric disorders have been reported. Therefore, we examined whether a seasonal variation exists in posttraumatic stress disorder (PTSD). Charts of Vietnam veterans with PTSD (N = 160) admitted to a Veterans Administration Medical Center during a 3-year period were reviewed for season of admission. We found that admissions for PTSD were significantly more frequent in spring and summer. These preliminary results suggest the possibility that seasonal factors may influence PTSD.

Combat Disorders↗
PubMedDate not supplied

Neuroticism and depression in alcoholics.

BACKGROUND: To examine neuroticism as a possible determinant of depression in alcoholics. METHOD: 24 euthymic depressed alcoholics and 18 never-depressed alcoholic controls completed the Eysenck Personality Questionnaire. RESULT: Euthymic depressed alcoholics had significantly higher neuroticism scores than alcoholic controls. LIMITATION: No women alcoholics were studied. CONCLUSION: Neuroticism may be a risk factor for depression in alcoholics.

Adult↗
PubMedDate not supplied

CSF 5-HIAA correlates with neuroticism in depressed patients.

BACKGROUND: To examine for relationships between neurotransmitters and personality. METHOD: 27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ). RESULT: CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores. CONCLUSION: Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression. LIMITATION: The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.

Adult↗