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Biomedical subjects

A Routh

Publications and source records attributed to A Routh.

35 records · Page 2Linked to original sources
PubMed1984

Oxygen at 2 atmospheres absolute pressure does not increase the radiation sensitivity of normal brain in rats.

Cranial radiation was administered to CD Fisher rats at 1.0, 1.5 and 2.0 atmospheres absolute oxygen pressure. Life span following radiation was recorded. Surviving animals were killed at 28 weeks and the brains were examined independently by two neuropathologists. Survival time was significantly less in animals receiving higher doses of radiation but showed no relationship to the oxygen pressure in the environment of the animal at the time radiation was administered. Microscopic examination of the brain did not reveal any differences in animals radiated in a normobaric or hyperbaric oxygen environment. It is concluded that hyperbaric oxygen does not sensitize the normal brain to the effects of ionizing radiation.

Animals↗
PubMed1983

Thymus irradiation for myasthenia gravis.

Twenty-eight patients with progressive myasthenia gravis without thymoma received treatment of 3000 rads (30 Gy) to the anterior mediastinum, and a followup was conducted for five to 18 years. Twenty-four patients had generalized myasthenia, and four had ocular myasthenia gravis. Twenty patients with generalized myasthenia survived the several month post-treatment period and improved, but four died during that period. The improvement lasted a median of 1.5 years, and older patients had longer remissions than younger patients. The four patients who had ocular myasthenia did not change after treatment. Mediastinal irradiation produces a temporary remission in generalized myasthenia.

Adolescent↗
PubMed1982

Microglioma.

Explore the source record for details and available documents.

Brain Neoplasms↗
PubMedDate not supplied

Non-Hodgkin's lymphoma of the spinal cord.

A 57-year-old white female, operated on for a prolapsed disc six years ago, presented with low back pain. Initially, she was thought to be suffering from the same disc problem, and was treated accordingly. However, her condition worsened. A myelogram disclosed a complete block of the subarachnoid space from levels T11 to L2. Laminectomy and decompression were performed, revealing tumor in the extradural space. Histological examination disclosed a primary, poorly differentiated lymphocytic lymphoma of the spinal cord. Both primary and metastatic non-Hodgkin's lymphoma of the spinal cord are extremely rare. Mullins et al described only five instances of cord compression in a study of 529 cases of non-Hodgkin's lymphoma. The diagnosis is generally not suspected until laminectomy.

Female↗
PubMedDate not supplied

Management of malignant thymoma.

Six cases of malignant thymoma were treated by various methods, i.e., surgery, radiotherapy and chemotherapy. The combination of surgery and radiotherapy seems to be the most effective method of treatment. Histology does not seem to influence survival.

Adult↗
PubMedDate not supplied

Comparison of survival of black and white patients in each stage of Hodgkin's disease during 1970-1980.

A survival and mortality study of all the patients referred to the radiotherapy department between 1970 and 1980 with a diagnosis of Hodgkin's disease was performed. Generally, black patients with cancer have a poorer survival rate compared with that of white patients with cancer, as reported by the U.S. Department of Health and Human Services. In this series, no difference in survival and mortality was found between patients of the two races when they were compared in each stage of Hodgkin's disease.

Black People↗
PubMedDate not supplied

Report of a prospective trial--split course versus conventional radiotherapy in the treatment of non small cell lung cancer.

A prospective randomized trial was started in January 1982, to compare morbidity and survival of two different radiation regimens for the treatment of non-small cell lung cancer (NSCLC). The trial was closed in December 1988. One group of patients was treated by conventional daily radiation therapy, and the other group by split course therapy. To maintain uniformity, a single physician staged and treated all patients and noted morbidity during treatment. Two hundred seventy-three consecutive lung cancer patients were treated. Only patients who completed the full radiation therapy course were included in this study. One hundred fourteen patients were treated with split course therapy, and 159 patients were treated by conventional daily radiation therapy. A few patients did not return for the second course of treatment, which accounts for the different number of patients in the two arms of the study. There was no statistically significant difference in survival between the two arms. Median survival for the split course and the continuous fraction therapy regimens was 11.6 months and 10.9 months, respectively. Split course radiation was associated with less morbidity.

Adult↗