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Biomedical subjects

A Rousseau

Publications and source records attributed to A Rousseau.

At least 91 records · Page 5Linked to original sources
PubMed1984

Utilization of membranous lipid substrates by membrane-bound enzymes. Intramembrane and intermembrane hydrolysis of diacylglycerol by lipase of rat liver microsomes.

The membranous lipase of rat liver microsomes was used to hydrolyze diacylglycerol (DG), generated within the microsomal membrane by treatment with phospholipase C, in two separate interactions. For an intramembrane enzyme-substrate interaction, the enzyme and DG were present in the same microsomes. For intermembrane interactions, native microsomes of rat liver were used as carriers of the enzyme, while heated and phospholipase C-treated microsomes of rat liver or brain were employed as carriers of the substrate. The v vs S curves of the intermembrane interaction were hyperbolic while those of the intramembrane utilization were parabolic.

Animals↗
PubMed1983

[Biological study of a case of analbuminemia].

A new case of analbuminemia in a fifty-four-year-old French woman is described. The patient was admitted to a hospital cardiology department for thoracic pain. Consanguinity between the patient's parents was established. Proteins were studied both during the acute phase and the subsequent remission. Total serum protein concentrations were stable, around 5.3 g. Hypoalbuminemia was compensated initially by alpha-2-globulins and subsequently by beta globulins. Increases in serum cholesterol and serum beta lipoproteins were recorded. Hydroelectrolytic balance was normal. Orthostatic renin and aldosterone release was significantly increased, denoting response to lowered hydrostatic pressure. A minor increase in serum thyroxin was recorded, probably because of the increase in thyroxin binding globulin.

Bilirubin↗
PubMed1983

Subcellular distribution of diacylglycerol lipase in rat and mouse brain.

Rat Brain has a lipase which hydrolyzes diacylglycerol at an optimal pH of 4.8 (1). The subcellular distribution of this acid diacylglycerol lipase was studied in brain tissue of rats and mice; in the latter case neurological mutants and their normal controls were used. Several other acidic hydrolases were employed as normal controls were used. Several other acidic hydrolases were employed as lysosomal markers. In mouse brain, the specific activity which is about 50-100 times lower than in rat brain, was greatest in the lysosomal fraction. In contrast, no enrichment of DG-lipase was observed in any subcellular fraction of the active enzyme of rat brain. Activities were about equally distributed in the microsomal, myelin-synaptosomal and lysosomal fractions.

Animals↗
PubMed1981

[The pterygo-maxillary fossa (infra-temporal fossa). Topographical division. Methods of investigation. Transmandibular approach to the region of the pterygoids (author's transl)].

The pterygo-maxillary fossa, hidden behind the face under the base os the present time. The scanner has transformed the investigation of this region and offers the possibility of discovery of processes limited to the pterygo-maxillary fossa which was above all known as an area affected by the extension of tumour processes arising in the maxillary sinus of parotid. A topographical division of the pterygo-maxillary fossa is suggested on the basis of CT pictures and surgical approaches. The region of the pterygoids may be easily reached via a transmandibular, the technique of which is described.

Adult↗
PubMed1980

[Febrile acute torticollis (author's transl)].

Febrile acute torticollis in the child represents a special clinical picture. Of variable cause, it may be indicative of an inflammatory, infectious or dystrophic pathology affecting any of the anatomical structures of the neck. Treatment is quite clearly defined, and it may be a therapeutic emergency. All ENT specialists must be familiar with this since they are most likely to be the first physician to whom such a child is brought.

Acute Disease↗
PubMed1979

Interaction of membranous enzymes with membranous lipid substrates. Hydrolysis of diacylglycerol by lipase in rat brain microsomes.

The phospholipids in rat brain microsomes were labeled with tritium by intracerebral administration of radioactive fatty acids and converted to diacylglycerol with phospholipase C. The latter lipid was hydrolyzed in situ at pH 4.8, to monoacylglycerol and fatty acid by the endogenous microsomal lipase. This paper provides an experimental approach to determine whether the lipid was degraded by enzyme molecules residing in its own membrane (intramembrane interaction) or an adjacent membrane (intermembrane interaction). Direct interaction between separate membranes containing enzyme or substrate showed the existence of the inter-membrane route while dilution experiments provided evidence for the presence of the intramembrane interaction as well. A probable difference in the mechanisms of these two interactions is suggested by different shapes of the curves that describe the reaction rate as a function of the endogenous substrate. The curve resulting from the intermembrane interaction was hyperbolic while that representing the intramembrane route was of a parabola-like shape. Competition experiments suggested that when given a choice between the two, the enzyme utilized preferentially the substrate molecules in its own membrane.

Animals↗
PubMed1977

[Role of photocoagulation in central serous choroidopathy].

We reviewed thirty-two cases of central serous choroidopathy and retained twenty-five for a twelve-month study of the natural history of this disease. The main conclusions are that the disease is benign and self-limited; it sometimes leaves sequelae such as subnormal visual acuity because of faveolar leak through Bruch's membrane; photocoagulation is useful only in a minority of cases.

Adult↗