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Biomedical subjects

A Rotondo

Publications and source records attributed to A Rotondo.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Myelography with B 15000, a new nonionic water-soluble contrast medium. Technical aspects and preliminary clinical experiences (author's transl)].

This is a report of myelography findings obtained in 50 patients with B 15000 (Iopamidol), a new non ionic water-soluble contrast medium. The procedure was easily carried out with a tilting table wired to a TV image amplifier. The dose of contrast medium injected intrathecally was 10 divided by 15 cm3 of a preconstituted solution containing iodine 200 or 300 mg/cm3. There were no accidents or major complications. The myelograms obtained with the test material afforded accurate diagnosis of intramedullary and extramedullary lesions, and signally of intervertebral disk protrusion and hernia.

Adolescent↗
PubMedDate not supplied

One-shot percutaneous ethanol injection of liver tumors under general anesthesia: preliminary data on efficacy and complications.

PURPOSE: To verify the efficacy of ultrasound (US)-guided injection of large amounts of ethanol into large or multiple liver lesions, in a single session under general anesthesia (one-shot PEI) for percutaneous ablation of hepatic tumors. METHODS: Twenty-nine patients (27 with 51 hepatocellular carcinoma (HCC) nodules on cirrhosis, diameter range 1.0-9.0 cm; two patients with a single metastasis from the gastroenteric tract, 5.0 and 9.0 cm, respectively, in diameter) were treated with one-shot PEI. RESULTS: The total volume of alcohol delivered per patient ranged from 16 to 210 ml. Mean ethanol volume in all patients was 49 ml. Dynamic computed tomography (CT) examination showed complete necrosis in 41 of 50 lesions. Two patients died of hypovolemic shock due to massive upper gastrointestinal bleeding, 3 and 7 days, respectively, after the interventional procedure. All the remaining patients are alive (follow-up 5-14 months) except one who died of liver failure 5 months after. New HCC nodules occurred in six patients within 6 months and one intralesional relapse was recorded. CONCLUSION: In this preliminary experience, one-shot PEI is as effective in inducing liver tumor necrosis as traditional PEI; its advantages are shorter treatment time and the capability of treating larger and multiple liver lesions.

Aged↗
PubMedDate not supplied

Water enema transvaginal ultrasound for local staging of stenotic rectal carcinoma.

BACKGROUND: To increase the value of ultrasound in the staging of stenotic rectal carcinoma. METHODS: Water enema transvaginal ultrasound (WE-TVUS) was performed in 21 consecutive female patients with severely stenotic rectal tumor (adenocarcinoma histologically proved) who were selected on the basis of clinical and double-contrast barium enema study. All patients underwent surgery, and histopathologic correlation was possible. RESULTS: Rectal tumors were well demonstrated in all cases, and a good correlation between perirectal neoplastic infiltration, and lymph node involvement at WE-TVUS and histologic data were observed. Compared with histologic results, WE-TVUS correctly staged 19 of 21 tumors (overall accuracy = 90%); one case was understaged (T4 as T3) and one case was overstaged (T3 as T4). In the detection of lymph node involvement, the sensitivity was 50% and specificity was 78%. CONCLUSION: WE-TVUS is a potentially valuable technique for defining the local extension of severely stenotic rectal tumors in women.

Adenocarcinoma↗
PubMedDate not supplied

[Computerized tomography in the study of the diabetic kidney].

PURPOSE: We investigated whether any morphometric or densitometric changes are detectable in the kidneys of type 2 diabetic patients. MATERIAL AND METHODS: We retrospectively reviewed the CT findings of 40 diabetic patients and of 20 non-diabetics (the control group) submitted to triphasic helical CT for different abdominal conditions. The type 2 diabetic patients were 23 men and 17 women, mean age 62 years, while the nondiabetic controls were 12 men and 8 women, mean age 58 years. All the CT images were analyzed using the Multiplanar Reconstruction (MPR) software. We classified the diabetic patients as either nephropathic or non-nephropathic based on laboratory signs of renal disease, and divided them into three groups based on the duration of their diabetes (0-5 years, 5-10 years, > 10 years). We evaluated morphometric features, such as the presence of parenchymal or vascular calcifications, axial and coronal renal diameters, coronal renal area, and corticomedullary ratio, and densitometric and functional features, such as unenhanced renal density, cortical and medullary density in the arterial phase, parenchymal density in the nephrographic phase, and contrast elimination. We also compared the results in our subgroups of patients with those in the controls. RESULTS: Both renal diameters on axial sections and cortical density in the arterial phase were significantly lower in the nephropathic group (p < 0.05) than in nonnephropathic patients and controls. The patients with shorter duration of their diabetes had significantly greater axial diameters (p < 0.05); a longer-standing disease correlated significantly (p < 0.05) with smaller axial diameters of kidneys and lower cortical density in the arterial phase. No significant correlation was found for any other parameter. CONCLUSIONS: Renal diameters on axial and coronal sections and cortical density in the arterial phase can be useful indices of early nephropathy in diabetic patients. Further studies are warranted to make these findings suitable for use in clinical practice.

Adult↗
PubMedDate not supplied

[Benign and malignant gastric ulcer: CT findings].

PURPOSE: To evaluate the differential CT aspects of benign and malignant gastric ulcers. MATERIALS AND METHODS: We retrospectively reviewed the CT findings of 54 patients with gastric ulcerative lesions, 47 with malignant lesions (38 adenocarcinomas, 9 lymphomas) and 7 with benign lesions. All patients underwent histological examination. CT scanning was performed with a helical scanner Picker PQ 2000, before and after intravenous contrast material administration and after adequate stomach distension, achieved by drinking at least 400 ml of water; 2 ml/kg of intravenous contrast was injected at a rate of 3.5 ml/s. After contrast administration two-phase dynamic scans were performed with a scan delay of 30O and 50O. The parameters considered were: lesion size and localization, extension of the ulcer into or beyond the body of the stomach, focal wall thickness, contrast enhancement of the ulcer, perigastric tissue morphology, presence of lymphoadenopathies and liver metastases. RESULTS: The ulcer size and localization were not significative in the differential diagnosis of benign or malignant ulcers. In 46 patients the ulcer extended within the body of the stomach (38 adenocarcinomas and 8 lymphomas), in 8 cases beyond (7 benign ulcers and 1 initial lymphoma). In 46 cases of malignant ulcers there were focal wall thickenings (> 5mm), in 1 case of initial lymphoma and in all cases of benign ulcers the thickness of the wall was normal. Contrast enhancement of the lesion was observed in 25 cases, all of which were adenocarcinomas. 33 patients had perigastric tissue abnormalites (32 with malignant lesions and 1 with benign ulcer). Lymphoadenopathies and liver metastases were detected in 30 cases and always associated to malignant ulcers. DISCUSSION AND CONCLUSIONS: The improved CT technology allows to recognize gastric ulcer. Ulcer extension into stomach body; focal wall thickening; contrast enhancement of the lesion, lymphoadenopaties and liver metastases are significative in malignant gastric ulcers. The lack of these abnormalities is characteristic of benign gastric ulcers but can be also observed in early malignant lesions.

Adult↗
PubMedDate not supplied

Hereditary haemorrhagic telangiectasia: study of hepatic vascular alterations with multi-detector row helical CT and reconstruction programs.

PURPOSE: To evaluate hepatic alterations in patients affected by Hereditary Haemorrhagic Telangiectasia (HHT) by using multidetectorrow helical CT (MDCT) and new reconstruction programs. MATERIALS AND METHODS: An MDCT multiphasic study of the liver was performed in 105 consecutive patients: 89 considered to be affected by HHT and 16 with suspicion of disease alone. The scan delay was determined by using a test bolus of contrast material. The CT examination was performed with a triphasic technique (double arterial phase and portal venous phase). Multiplanar and angiographic reconstructions were then obtained, and the images checked for the presence of shunts, hepatic perfusion disorders, vascular lesions (telangiectases and large confluent vascular masses), indirect signs of portal hypertension, and anatomical vascular variants. RESULTS: Hepatic vascular alterations were found in 78/105 cases (67/89 patients affected by HHT and 11/16 patients with clinical suspicion alone). Therefore HHT diagnosis was excluded in 5 patients. 78/100 (78%) patients with HHT had intrahepatic vascular alterations: arterioportal shunts in 40/78 (51.2%), arteriosystemic shunts in 16/78 (20.5%), and both shunt types in 22/78 (28.3%). Intraparenchymal perfusion disorders were found in 46/78 (58.9%) patients. Telangiectases were recognised in 50/78 (64.1%) patients. Large confluent vascular masses (LCVMs) were identified in 20/78 (25.6%) patients. Indirect signs of portal hypertension were found in 46/78 (58.9%) cases. Variant hepatic arterial anatomy was present in 38/100 cases (38%). CONCLUSIONS: Multiphasic MDCT and the new reconstruction programs enable the identification and characterisation of the complex vascular alterations typical of HHT.

Adolescent↗
PubMedDate not supplied

[CT-guided FNAB with 22-g needles of thoracic-abdominal formations].

The authors describe the results of their series of 260 fine (22G) needle aspiration biopsies (FNAB) of thoracic and abdominal lesions. Diagnostic accuracy, technique, eventual complications are valued. They recommend that this diagnostic procedure is performed with 22G needle and scrupulous technique; the FNAB, if so carried out, is a sure, quick and high accurate tool to characterize uncertain lesions, avoiding explorative surgery.

Abdominal Neoplasms↗
PubMedDate not supplied

CT in the diagnosis of sellar and parasellar lesions.

The Authors review their recent experience in investigating 185 cases of sellar and parasellar lesions, using as preliminary procedure stratigraphy and CT; further examinations were performed only in cases with unclear diagnosis. Their data confirm the reliability of this non-invasive protocol that allowed the detection of pathological changes in nearly 95% of cases and was able to define with certainty the nature of the lesions in over 72% of cases. However, other investigations were performed in 116 cases (63%): in 57 (31%) for diagnostic purpose, in 59 (32%) as complementary pre-operative studies.

Adenoma↗
PubMedDate not supplied

[Defecography study of outpouchings of the external wall of the rectum: posterior rectocele and ischio-rectal hernia].

PURPOSE: To report the clinical and defecographic features of posterior rectal wall outpouchings, i.e., posterior rectocele and ischiorectal hernia. MATERIALS AND METHODS: Sixty-six patients with posterior rectal wall outpouching (61 with posterior rectocele and 5 with ischiorectal hernia) were selected among the patients examined in the last two years for defecation disturbance. All patients underwent physical examination, rectoscopy and videodefecography. RESULTS: Posterior rectal wall outpouchings were detected at physical examination in 28 patients and at rectoscopy in 9 patients. Posterior rectocele, more frequent and bigger in men, was usually demonstrated at videodefecography as an outpouching of the lower portion of posterior rectal wall: this finding was visible only in the dynamic phases in 51 patients while it was seen also at rest in 10 patients. In 52 patients, posterior rectocele was associated with other abnormalities--i.e., anterior rectocele (64%), puborectal muscle syndrome (38%), descending perineum (33%), mucosal prolapse (33%) and intussusception (20%). An ischiorectal hernia, defined as a posterolateral ampullar outpouching deeper than 4 cm and already visible at rest, was identified in 5 patients. Descending perineum and anterior rectocele were the most common associated disorders. CONCLUSIONS: We report the clinical and defecographic features of these rectal abnormalities and stress the importance of videodefecography in the real-time study of these morphofunctional disorders.

Adult↗