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Biomedical subjects

A Roth

Publications and source records attributed to A Roth.

At least 343 records · Page 19Linked to original sources
PubMed1982

[Teratoma of the renal sinus. Apropos of a Case].

The authors report a new case of teratoma of the renal fossa. Such tumours are rare. The case reported is unusual since it involved an older child and because the small lesion was located in the renal sinus and not in the parenchyma.

Child↗
PubMed1981

Preliminary report on antitumorigenic activity of cis-dichlorodiamine platinum in metastatic brain tumors.

In spite of pharmacokinetic studies, which have shown that only cis-DDP traces are found in brain tissue, cytotoxic activity of this drug in primary brain tumors has recently been reported. The purpose of our study was to examine whether cis-DDP aslo has antitumor properties in metastatic brain tumors. Twelve consecutive untreated patients with brain metastases recorded by CAT scans or radionuclide scans plus neurologic examinations underwent the treatment. Histology of primaries revealed 4 bronchial, 3 breast, 1 gastric, 2 colorectal carcinoma, 2 melanomas, and 1 soft tissue sarcoma. Cis-DDP was administered at the doses of 30 mg/m2 body surface daily for 4 days. All the patients were evaluated. Objective response (3 complete and 2 partial remissions) was observed in 5 of 12 patients (response rate 42%). Three stable disease cases were also noted; however, in the remaining 4 patients the disease in the brain progressed. Complete response (5 months) was observed in a breast cancer patient, in a melanoma (4+ months), and in a microcellular bronchial cancer (2+ months). Two partial responses (lung, breast) lasted 2+ and 2+ months. Toxicity was moderate but tolerable for the patients. The preliminary results of this study show that cis-DDP possesses antitumorigenic properties also in patients with metastatic brain tumors, which has not been proved till now.

Adult↗
PubMed1981

Diagnosis of penicillin allergy by means of Phadebas RAST penicilloyl G and V and skin tests.

Fifty patients with suspected allergy to penicillin were tested. Skin tests were done with Na-penicillin G and penicilloyl-polylysin. Specific IgE antibody assays were done with penicilloyl G and V conjugates by means of RAST. The overall agreement between skin test and RAST results was 87%, borderline cases not included. In one case, skin tests were positive to penicillamine only, while RAST for penicilloyl G and V both proved to be positive. One case of penicillin allergy could be diagnosed in vitro post mortem only. Two cases of Hoigné syndrome showed no evidence of allergy. Patterns of skin manifestations varied but urticaria was the most commonly seen feature. Twenty patients without adverse reactions to penicillin treatment and seven patients who had not received penicillin over the last 10 years served as controls. None of them were positive in either skin tests of RAST. Two or our twenty control patients developed penicillin allergy during the study. Both showed positive RAST results.

Adolescent↗
PubMed1981

Radioallergosorbent test with conjugates specific for 'minor' haptenic determinants in the diagnosis of IgE-mediated penicillin allergy in man.

Penicillamine-polylysine, benzylpenicillanyl-human serum albumin and ampicillin-polymers were coupled to CNBr-activated paper discs and used in addition to penicilloyl G and penicilloyl V discs in RAST investigations. Sera from sixty patients with case histories of penicillin allergy and with positive or negative skin tests to different penicillin determinants and from seventeen subjects with atopic diseases caused by allergens other than penicillin were tested. The penicilloyl-('major' determinant) specific RAST (Phadebas RAST Penicilloyl G and V) was positive in twenty out of twenty-four patients with positive skin tests to penicilloyl-polylysine, in eight out of twelve patients with sole skin reactivity to 'minor' determinants, and in five out of twenty-four patients with negative skin tests to all antigens used. The penicillamine-specific RAST was the only positive in vitro test in four patients with negative skin tests (two) or sole positive skin reactivity to 'minor' determinants (two), whereas benzylpenicillanyl and ampicillin-polymer discs added no more information than the penicilloyl structures in all patients tested. Antibodies specific to 'minor' determinants apparently show strong in vitro cross-reactivity with the penicilloyl determinant. It is, therefore, concluded that 'minor' determinant specific conjugates are of marginal importance for in vitro diagnosis of penicillin-allergic patients.

Benzeneacetamides↗
PubMed1981

Pupil cycle induction test: a way of evaluating the pupillary light reflex.

The Pupil Cycle Induction Test (PCIT) described here is a simple and sensitive clinical method for the evaluation of afferent pupillary defect. It assesses the difficulty in setting up regular and sustained light-induced pupil oscillations, in contrast to methods assessing the light reflex by timing the oscillations. PCIT was applied to 186 presumably normal eyes (with normal visual acuity and normal fundi). In ten eyes, sustained oscillations could not be induced; further investigation showed that four of these eyes had altered visual-evoked response. The test was also carried out in 34 patients suffering from anterior visual pathway disorders. Sustained pupil oscillations could not be set up in 44 out of the 57 affected eyes. In the present series, significant alteration of light-induced pupil oscillations has been observed in several patterns: (1) immediate alteration; (2) delayed interruption of oscillations without spontaneous recovery, and (3) intermittent periods with oscillations of relatively small amplitude lasting more than three pupil cycles. PCIT assesses changes in light threshold for pupil response. It is suggested that delayed and transient alterations of oscillations are related to time-dependent afferent pupil defects similar to intermittent abnormalities of visual function reported in patients with diseases of the optic nerve or the chiasm.

Adolescent↗
PubMed1981

Influence of central depressant drugs on pupil function: an evaluation with the pupil cycle induction test.

Afferent pupillary defect is an early sign of optic nerve or chiasm disease. It can be evaluated by the Pupil Cycle Induction Test (PCIT) which assesses the difficulty in setting up regular and sustained pupil oscillations. PCIT was carried out in 30 subjects with presumably normal visual function (normal visual acuity and normal fundi) and taking benzodiazepines and/or barbiturates. In 42 out of the 60 tested eyes, response to PCIT was altered. This emphasizes the necessity of a detailed drug-taking history when investigating anterior visual pathways by means of pupil function, especially when one considers the extensive use of central nervous system depressant drugs by the general population.

Adolescent↗
PubMed1981

Esophageal tumors--the role of esophagoscopy.

In Yugoslavia, esophageal cancer is the fourth most frequent malignant disease of the gastrointestinal tract, after stomach cancer, rectum, and colon cancer. Incidence of esophageal cancer in Croatia in 1975 was 6.0 per 100,000 population for males, and considerably less for females with 1.4 per 100,000 population. There is not a statistically significant difference in the incidence of esophageal cancer in the different regions within Croatia. During the period from March 1973 to April 1980 at the Central Institute for Tumors and Allied Diseases in Zagreb, esophagoscopy was performed on 179 patients with esophageal tumors. Test results of 170 patients was 60.4 years (male 60.0, female 62.4). The authors present the analyses of histopathologic types of tumors. In 79.4% of patients (135/170) squamous cell carcinoma was found. In 69 patients histologic findings were compared with cytology. In six patients, only the cytological examinations were positive. Furthermore, the localizations of tumors in the esophagus were analyzed, and in 53.6% of patients (91/170) tumor was localized in the middle third of the esophagus. In almost all cases the disease was advanced and inoperable. Smoking and alcoholism were analyzed as potential etiological factors. The authors consider that esophagoscopy could be a valuable method in the early detection of esophageal carcinoma in the high risk group of the population (men over 50 years of age who are heavy alcoholics and smokers).

Adult↗