[Ultrastructure of early fatty infiltration in the myocardium after administration of rapeseed oil in the diet].
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Biomedical subjects
Publications and source records attributed to A Rosnowski.
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Electron microscopy was applied to study the myocardium of rats fed a diet with sunflower oil (group I), low-erucic acid rapeseed oil (group II), or high-erucic acid rapeseed oil (group III). The most severe lesions were found in group III. The rats fed sunflower oil showed slight lesions in the form of dilated channels of endoplasmic reticulum and the presence of a few lipid droplets. Similar abnormalities were found in group II, they were followed, however, after four and eight weeks of experiment by considerable mitochondriosis with compression and atrophy of sarcomeres. In group III considerable myocardial fatty degeneration (numerous lipid vacuoles) was found already after the first week of experiment, after four and eight weeks, however, the number of lipid vacuoles gradually decreased with time. Like group II group III showed considerable mitochondriosis with atrophy of contractile elements.
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102 patients with clinically established diagnosis of Buerger's disease were treated and operated upon by the authors, in 45% of cases histology was obtained proving the clinical diagnosis. Buerger's disease is a rare pathology in Poland, it has been recognised in 3.3% of patients presenting with peripheral arterial pathologies. 46% of patients were followed up for 2-10 years. Clinical, radiological and histological documents demonstrating the gradual evolution of the disease have been presented.