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Biomedical subjects

A Rosenbaum

Publications and source records attributed to A Rosenbaum.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Mammary localization of malignant non-Hodgkin's lymphomas. Apropos of 4 cases].

Mammary localizations of non-hodgkinian malignant lymphomas (NHML) are rare. They occur in three different contexts: isolated tumor of the primary mammary lymphoma, initial "first manifestation" tumor of a diffuse lymphomatous disease, or else a mammary tumor occurring during the course of a known NHML. Four cases of mammary localization of NHML are reported. A review of the literature permits to bring out the following characteristics: probable etiological role of pregnancy, clinical picture of one or several masses, uni or bilateral, evoluting rapidly, and frequently associated to inflammatory signs; false benign aspect on mammograms. Histological examination associated with a strict evaluation of the extension is fundamental in order to determine therapy and prognosis. These two factors have been considerably modified in the past two decades as it is the case for all NHML. Chemotherapy occupies an essential place in the treatment. Mammary localization of NHML is first of all a lymphomatous disease, which is often a diffuse disease before becoming a breast disease.

Adult↗
PubMed1986

beta-Endorphin/beta-lipotropin immunoreactivity in endogenous depression. Effect of dexamethasone.

This study addresses the question of whether pituitary peptides (ie, beta-endorphin) show regulatory disruption in endogenous depression and, if so, does it co-occur in the same subjects who show cortisol dysregulation. Endogenously depressed patients and psychiatric controls from three centers were evaluated, when not taking medications, and studied for plasma cortisol and beta-endorphin levels. Plasma samples were taken at four time points over one hour, on the basal day, and 16 hours after 1 mg of dexamethasone. From 33% to 69% of the endogenous patients were abnormal in their postdexamethasone cortisol levels, and from 50% to 69% were abnormal on postdexamethasone beta-endorphin values (vs 0% and 8%, respectively, for controls). When endogenous subjects were evaluated for abnormality on both cortisol and beta-endorphin, after dexamethasone, it was found that the two measures of hypothalamic-pituitary-adrenal dysfunction did not necessarily co-vary. In fact when having either abnormal beta-endorphin or cortisol levels (or both) was used as a biological marker a larger number of the endogenous patients were detected than with either measure alone. Our conclusions are as follows: Plasma beta-endorphin shows a circadian rhythm similar to that seen with corticotropin (ACTH) and is suppressable by dexamethasone. In many endogenous patients plasma beta-endorphin levels escape from dexamethasone suppression. Many of these subjects are not cortisol escapers. When abnormality of either the beta-endorphin or cortisol is considered it is clear that both levels of the hypothalamic-pituitary-adrenal axis can be dysregulated in endogenous depression.

Adolescent↗
PubMed1982

[Trial of the therapeutic efficacy of cis-diamino-dichloro-platinum by local instillations on bladder tumours recurring at the original site (author's transl)].

Cis-diamino-dichloro-platinum (DDP) was administered to fourteen patients with a carcinoma of the bladder recurring at the original site and all analysed from a histological standpoint. All the patients had received multiple therapy previously. The tumours treated included the following: eight superficial tumours not infiltrating the chorion, four tumours involving the chorion, one tumour involving the internal muscle layer and one tumour in situ. The age range of the patients was 52 to 81 years with a mean of 69.6 years. Administration was by intra-vesical instillation of 100 mg of DDP each week for the first six weeks, then every two weeks for the next two months and finally once a month. Results were assessed on the basis of endoscopic appearance, cytology and, where applicable, biopsy. Amongst the superficial tumours not infiltrating the chorion, results were as follows: three complete remissions of respective durations of 8 months, 5 months and more than 2 months; three partial remissions of respective durations of 7 months, 6 months and 5 months; and finally two minor remissions of 5 months and 2 months. There were no failures. Amongst tumours invading the chorion, results were as follows: one complete response lasting for 10 months; 2 minor remissions of short duration: 2 months and 2 months; and one failure. Treatment of the one tumour invading the internal layer of muscle was a failure. Finally, the tumour in situ was difficult to evaluate but showed a complete response lasting for 2 months.

Adult↗
PubMed1980

The value of CT in genetic counseling in tuberous sclerosis.

The families of two patients with known tuberous sclerosis were electively evaluated by computed tomography. The CT positive (and negative) examination proved to be valuable for the genetic counseling of family members without overt clinical manifestations of tuberous sclerosis. Two patients had evidence of smaller enhancing lesions (minimal demonstrable mass without hydrocephalus) following intravenous contrast enhancement. We, therefore, suggest the use of contrast enhanced scans in addition to the plain scans to identify what may represent occult neoplasms. Abdominal CT scans can prove useful in identifying the frequently associated renal hamartomas.

Adolescent↗
PubMed1979

Diagnostic approaches to pituitary adenomas.

The utility of diagnostic tests for pituitary adenoma was compared in 12 patients. Endocrine and radiologic studies were always abnormal, even when neuro-ophthalmologic tests were normal. In most cases, both tomography of the sella turcica and CT scan revealed a mass in the region of the sella turcica. For more precise definition of suprasellar extension of the mass, metrizamide CT cisternography or tomographic pneumoencephalography with metrizamide provided similar details, although CT cisternography was much more easily done. Angiography provides a means to exclude an aneurysm or vascular malformation, a vascular tumor, or an aberrant course of the internal carotid artery.

Adenoma↗
PubMed1978

Fluorescent lighting: a purported source of hyperactive behavior.

Seven first-grade children with conduct disorders and/or hyperactivity attended full-day sessions at a laboratory school classroom. During an 8-week period, the classroom lighting conditions alternated at the end of each week. During odd-numbered weeks, the classroom was illuminated by a standard cool-white fluorescent system. On even-numbered weeks, illumination was a daylight-simulating fluorescent system of equal footcandles with controls for purported soft X rays and radio frequency (RF). There were no effects of lighting conditions on hyperactive behavior as assessed by (a) independent observations of task orientation or (b) ratings of activity level. A Critical Flicker Fusion (CFF) measure, a reported indicator of visual-sensory fatigue, indicated that the daylight-simulating condition was associated with a decreasing CFF across weeks.

Child Behavior Disorders↗
PubMed1976

Behavioral treatment of hyperkinetic children. An experimental evaluation of its usefulness.

Although drug therapy is helpful in the control of many children with hyperkinesia, alternative and adjunctive therapies are needed also, for a number of reasons: 1) not all of these children improve with medication; 2) the drugs may have adverse physiologic effects which at the least dictate caution in their use; 3) medication alone does not always return responding children to normal functioning; and 4) drug action cannot often be used to help with problems occurring in the children's home setting after school hours. The data here presented suggest strongly that behavior therapy can be effective for hyperkinesia.

Behavior Therapy↗
PubMed1975

The bleeding marginal ulcer. Catheterization diagnosis and therapy.

Superior mesenteric arteriography can often demonstrate actively bleeding marginal ulcers. Five cases diagnosed by angiography are reported. Pitressin infusions of the superior mesenteric artery stopped bleeding permanently in two cases, transiently in two cases, and was not attempted in one case. Pitressin infusions of the superior mesenteric artery should be attempted before surgery is performed for bleeding marginal ulcers.

Adult↗