Veralipride is a substituted benzamide which is used for the treatment of menopausal hot flushes. We report five cases with extrapyramidal disorders associated to a treatment with this drug for which the neuroleptic activity resulting from an interaction with D2 receptors is not always known by prescribers. One case consisted of acute dyskinesias and four of parkinsonian syndromes, one of these being associated with tardive dyskinesia. In these four cases, dosing recommendations were not respected.

Acute Disease↗

PubMedDate not supplied

[Meningopapillitis disclosing Lyme disease].

A 65 old year woman was admitted to the hospital for a low back pain, a fever and an elevated sedimentation rate. Four months later she noted a progressive visual loss first affected the right eye (visual acuity: 6/10) and then the left (visual acuity : 6/10). Fundus examination showed a bilateral papilledema. CT Scan and MRI were normal. A lumbar puncture disclosed a lymphocytic pleocytosis (68 leukocytes/mm3), an increase in protein level (1,9 g/l) and oligoclonal bands. A serologic test for B. Burgdorferi was positive both in blood (1/64 degrees) and in cerebrospinal fluid (> or = 1/128). The patient was treated with intravenous ceftriaxone 2 g daily for 2 weeks. Fifteen days later the low back pain had disappeared and the CSF cellular count had decreased to 20 leukocytes/mm3. Seven months later, CSF was normal (2 leukocytes/mm3, protein level: 0.65 g/l.); Titer against B. Burgdorferi had improved to 1/160 in serum and 1/16 in CSF; visual acuity had improved to 8/10 on left, and was the same on right.

Aged↗

PubMedDate not supplied

[Clinico-radiological data of 48 cases of immunocompetent primary cerebral lymphoma].

In this article clinical and neuroradiological features from a cohort of 48 immunocompetent patients who have a histologically proved primary cerebral lymphoma are considered. Our series consisted of 27 men and 21 women with an average age of 59. The clinical results gave 73% patients with a focal deficit, 46% with deterioration of vigilance, 35% intracranial hypertension, and only 8% with epilepsy, which was never revealing. We observed 4 uveitis of which 3 revealed, and preceded by several months, the neuroradiological manifestations. Histological classification using the criterias of the Working Formulation showed that 92% of our patients had a large cell lymphoma (class G or H). Precise analysis of computed tomography features of 40 patients revealed 46 lesions (most of them were isodense) before contrast medium administration. In all the cases, the lesion enhancement was intense and homogeneous. In 50% of the cases, there were multiple lesions. Sixty lesions were of the supra tentorial compartment, lobar in 32 cases, deep in 28 cases. Fifteen were infratentorial. From our experience, we can put forward the following suggestions: 1) Neuroradiological aspects suggesting primary cerebral lymphomas exist but none of them are specific. 2) Research of an uveitis is important, as this makes the histological diagnosis more simple. 3)The prescription of corticosteroids should be delayed until the histological diagnosis is certain because the primary cerebral lymphoma, which is very corticosensitive, is likely to disappear with this treatment and then change the biopsy results.

Adrenal Cortex Hormones↗

PubMedDate not supplied

[Apolipoprotein A1 and biliary lithiasis in hepatic cirrhosis].

A prospective study was performed in 67 male patients with cirrhosis, admitted in our Department during one year. Biliary lithiasis was found in 37% of patients. The occurrence of lithiasis was not related to age, weight or severity of liver disease. Seric total bilirubin was higher in lithiasic patients (p < 0.05). Apolipoprotein A1 levels were lower in those ones with lithiasis (p < 0.005). Apolipoprotein A1 was the only factor associated independently with the finding of lithiasis.

Apolipoprotein A-I↗

PubMedDate not supplied

[Pseudo-Creutzfeldt-Jakob syndrome with long-term lithium use].

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Aged↗

PubMedDate not supplied

Immediate implants placed into infected sites: a histomorphometric study in dogs.

The study the effect of chronically infected sites on the immediate placement of implants, periapical lesions were induced in the third and fourth premolars of four dogs and the contralateral teeth were used as controls. Nine months after the induction of periapical lesions, experimental and control teeth were extracted, and 28 IMZ implants were immediately placed. After a healing period of 12 weeks, the animals were sacrificed, the hemimandibles were removed, and specimens were prepared to be hard-sectioned and stained with toluidine blue. All areas healed without inflammation or exudation and all implants were clinically immobile and were radiographically determined to be surrounded by normal-appearing bone. Histologically, there were no signs of infection, and the histomorphometric analyses revealed that 28.6% and 38.7% had osseointegrated for the experimental and control implants, respectively. The difference was not statistically significant. It was concluded that chronically infected sites, such as those showing signs of periapical pathosis, may not be a contraindication for immediate implants, if certain clinical measures and preoperative and postoperative care are taken.

Animals↗