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Biomedical subjects

A Roman

Publications and source records attributed to A Roman.

114 records · Page 7Linked to original sources
PubMedDate not supplied

Totally implanted direct current stimulator as treatment for a nonunion in the foot.

Nonunions and delayed unions are postoperative complications with which the podiatric surgeon must be concerned. Although the incidence is infrequent, their treatment methods vary, and can range from bone grafting to internal and external fixation of fragments, arthrodesis, and/or the use of indirect and direct bone stimulation. This manuscript details a case of a nonunion of the first metatarsal cuneiform joint 8 months after attempted Lisfranc's joint fusion for Charcot arthropathy of the midfoot. The nonunion was treated with bone grafting, internal fixation, and the use of an implanted direct current bone stimulator. Although implanted bone stimulators are commonly used for the treatment of failed unions of the posterior spine, tibia, and humerus, to date, the authors submit this is the first reported case of implementing a totally implanted direct current stimulator for treatment of a nonunion in the foot.

Arthropathy, Neurogenic↗
PubMedDate not supplied

The crescentic shelf osteotomy.

The authors describe a new surgical technique for the correction of a hallux abducto valgus deformity. The crescentic "shelf" osteotomy combines a dorsal-to-plantar crescentic osteotomy with a medial-to-lateral transverse osteotomy at the first metatarsal base. This technique allows triplanar correction, stable open reduction with internal fixation, and precise intermetatarsal reduction. This article discusses alternate base osteotomies, anatomical considerations of the first metatarsal, and data predicting frontal and sagittal plane motion of the distal fragment. Also included is a procedural guide followed by examples and possible complications. An analysis of 22 procedures are presented. The article briefly introduces the capital crescentic shelf osteotomy with review of the procedure.

Adolescent↗
PubMedDate not supplied

Effect of repeated amitriptyline administration to mice on the T lymphocyte proliferative activity and natural killer cell cytotoxicity.

The study examined the effect of repeated amitriptyline administration to mice on the proliferative activity of lymphocytes in response to mitogen stimulation and on the ability of natural killer (NK) cells to evoke lysis of YAC-1 tumor cells in vitro. A relatively short treatment (5 days) produced an increase in the NK activity, but no change in the T cell proliferative response to mitogens. After a 2-week treatment, a transient but significant decrease in the proliferative activity of splenocytes and in the NK activity was observed. Prolonged administration of that drug for more than 3 weeks produced a return to the control level of the NK activity and the T lymphocyte responsiveness to mitogens. The obtained results show that amitriptyline modifies the immune function, and that the observed effect depends crucially on the length of drug administration.

Amitriptyline↗
PubMedDate not supplied

Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression.

A depression-like state was induced by chronic (3-week) exposure of Wistar rats to a very mild, unpredictable stress which is a model of depression, developed by Willner's group. Five-week daily administration of imipramine reversed the stress-induced deficit in sucrose consumption. Eight-week stress induced an increase in the ability of splenocytes to produce interleukin 1 (IL-1) and interleukin 2 (IL-2) and to proliferate after stimulation with concanavalin A. Antidepressant effects of imipramine were accompanied by a decrease in the ability of splenocytes to produce IL-1 and IL-2 and to proliferate. Administration of imipramine alone did not modify the activity of those cells.

Animals↗