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Biomedical subjects

A Roche

Publications and source records attributed to A Roche.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Does arterial embolization have a role in the treatment of cavernous hemangioma of the liver in adults?].

Embolization of the hepatic artery for cavernous haemangioma is discussed on the basis of 7 cases (3 giant haemangiomas, 4 medium sized or small), all symptomatic. Therapeutic embolization reduced the tumoral mass in 3 cases but had little effect on the symptoms. There was no complication. Arterial embolization is a relatively non-aggressive method, but it does not suppress the lesion. It should therefore be reserved to symptomatic or complicated cases, where reduction of the mass can be expected to result in functional improvement. Such cases are too exceptional for embolization to be performed routinely in adult patients with cavernous haemangioma of the liver.

Adult↗
PubMed1986

[Treatment of uncontrollable hemorrhage caused by esophageal varices in cirrhotics. Transhepatic embolization or emergency portal shunt].

The purpose of this study was to compare the results of two therapeutic methods used in an emergency to control oesophageal variceal bleeding resistant to medical treatment in cirrhotic patients: portal diversion (116 patients) or transhepatic embolization of the varices (84 patients). Portal diversion proved more effective in stopping the haemorrhage than embolization but the overall mortality rate was about the same with the two procedures. An analysis of the results taking into account the patient's condition failed to show any difference in mortality between the two methods. Indeed, the very high mortality rate in the most severely ill patients may oblige to question their usefulness in such cases. In the least severe patients, we prefer portal diversion which is quicker and can be performed at any time. In patients of the intermediate group transhepatic embolization seems to be less hazardous than portal diversion.

Embolization, Therapeutic↗
PubMed1984

Hepatic arterial embolization for malignant hypercalcemia in hepatocellular carcinoma.

A patient who presented with hypercalcemia was found to have an hepatocellular carcinoma. Medical treatment failed to normalize blood calcium levels. Liver resection was not feasible due to major extrahepatic involvement. Selective arterial embolization of the tumor was performed, resulting in correction of the hypercalcemia. This observation suggests that some life-threatening complications of unresectable hepatocellular carcinoma can be treated by arterial embolization of the tumor.

Carcinoma, Hepatocellular↗
PubMed1984

Tissue extraction of amiodarone and N-desethylamiodarone in man after a single oral dose.

The hepatic extraction of amiodarone and N-desethylamiodarone has been investigated in seven patients following catheterization of the portal and hepatic veins under general anaesthesia. Amiodarone (600 mg) was administered orally 4 h before regional blood sampling. Concentrations of amiodarone and N-desethylamiodarone, determined by h.p.l.c., were about twice as high in the portal vein compared with those in the hepatic vein, the calculated hepatic extraction ratios of both compounds being 0.39 +/- 0.07 and 0.34 +/- 0.03, respectively. The presence of N-desethylamiodarone in the portal vein in higher concentrations than in the hepatic vein strongly suggests that N-dealkylation of amiodarone occurs in the gut wall or lumen, a finding which might account for the low and highly variable intersubject amiodarone bioavailability.

Administration, Oral↗
PubMed1984

[Preoperative localization of insulinoma is necessary].

Many insulinomas because of their small size are not localized by routine investigations: abdominal ultrasound, angiography, computed tomography, nor at the step of laparotomy. Biological diagnosis is far more encouraging. Percutaneous transhepatic sampling of blood in the portal venous system is very predictable for adenoma localization. Absolute reliability of this method remains to be established, nevertheless the observance of some basic requirements are already known: withdrawal of any drug interfering with insulin release several days before performing the catheterism; need of a steady, preferably low, glucose level during the whole sampling; selective samples in tiny draining veins of the whole gland, and adequate radio-immunoassay. Transhepatic sampling can detect multiple localisations and diffuse hyperplasia but angiography alone is able to show hepatic metastasis and is helpful in giving the surgeon information on local vascularization. Confrontation of both angiography and transhepatic sampling gives the best criteria of localization. In case of discrepancy, transhepatic sampling seems to be more reliable.

Adenoma, Islet Cell↗
PubMed1984

[Stenosis of the left hepatic duct with intrahepatic lithiasis: treatment by the percutaneous transhepatic approach].

The authors report the case of a 78-year-old woman suffering from cholangitis secondary to intrahepatic biliary stricture and intrahepatic lithiasis. Successful management consisted of successive percutaneous transhepatic internal-external biliary drainage, balloon dilatation of the stricture and gallstone mobilisation and removal through the stricture. No complications were noted.

Aged↗