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Biomedical subjects

A Roche

Publications and source records attributed to A Roche.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

[Very severe haemorrhages of the lower digestive tract. The value of emergency arteriography (author's transl)].

The authors report six cases of massive lower gastro-intestinal tract haemorrhage, diagnosed by angiography. They emphasize the value of angiography performed on an emergency basis. It is the most reliable diagnostic modality to know before surgery the precise localization of the bleeding point and sometimes its aetiology. The interest and the problems of therapeutic angiography are discussed.

Adult↗
PubMedDate not supplied

[Embolization of hepatic metastases].

The results of 42 cases of arterial embolisation in patients with hepatic metastases are reported. In two-thirds of the cases the primary tumor was found in the gut. In eight cases endocrine tumor dissemination was incriminated. Arterial occlusion called for use of various inert substances (e.g. Spongel, Duremere) or cyanoacrylate, but in this instance chemical embolisation was excluded. The antalgic effect of embolisation (72 percent success rate) and antipyretic effect on persistent fever (60 percent success rate) constituted the usual indications. Metastases of secreting tumors are verily more rare, nevertheless they are indubitably a major indication for embolisation, since good results are achieved concerning inopportune secretions and repeat embolisations possible are a super advantage. The good symptomatic results of embolisation must incite its consideration in unoperable but nonterminal cases whose medical therapy is no longer or simply not effective.

Adult↗
PubMedDate not supplied

Transcatheter arterial chemotherapy using doxorubicin, iodized oil and Gelfoam embolization in hepatocellular carcinoma.

Computed tomography (CT) was performed in 54 patients with hepatocellular carcinoma three weeks after transcatheter arterial chemotherapy using iodized oil and doxorubicin with or without gelfoam embolization. Patients with iodized oil retention in the tumor greater than 50 per cent of tumor size survived longer than patients with retention of less than 50 per cent. Differences were also found within Okuda stages I and II, but they were significant only in Okuda stage I (p less than 0.0001). These results suggest a possible relationship between iodized oil retention and survival. In addition to Okuda stage, several factors affected iodized oil retention: tumor vascularity, tumor size, portal thrombosis and Gelfoam embolization. These factors may thus influence the prognosis after transcatheter arterial chemotherapy.

Adult↗
PubMedDate not supplied

[Arteriography in digestive hemorrhage].

As it appears from a review of the literature of the last decade, arteriography is important in the diagnosis and management of gastrointestinal haemorrhage but its role has to be evaluated by a multidisciplinary approach. In fact, the role of arteriography in upper gastrointestinal bleeding is often therapeutic, because diagnosis is often made by endoscopy. In lower gastrointestinal bleeding, arteriography is mainly diagnostic and its role in treatment remains limited. Controlled studies are necessary to compare transcatheter embolization with other treatments.

Angiography↗
PubMedDate not supplied

[Intravascular migration of fragments of central venous catheters. 3 cases].

Intravascular embolization of catheter fragments is a severe and rare complication of indwelling intravenous catheters. The estimated rate of incidence is 0,1% of central venous catheter insertions. This report of three cases shows how this complication may occur and suggests preventive measures. Mortality from arrhythmia-related cardiac arrest, septic and thrombo-embolic complications, and the risk of perforation of the heart argue for an immediate extraction of the broken catheter. Surgical removal used to be the only method; a non-surgical technique is now available, in which the embolized fragment is removed by means of a loop snare. No death has been associated with this technique which seems to be safe and reliable.

Adolescent↗
PubMedDate not supplied

Transluminal angioplasty of a stenotic surgical splenorenal shunt.

A stenosis of a side-to-side splenorenal shunt was treated by percutaneous angioplasty two years after the performance of the shunt. After dilatation, there was a fall of the splenorenal pressure gradient from 28 to 17 cm H2O and good transanastomotic flow was re-established. As in other arterial and venous territories, angioplasty may be an interesting alternative to surgery.

Angioplasty, Balloon↗
PubMedDate not supplied

Intrahepatic calculi: imaging by MR.

The magnetic resonance (MR) examinations of six patients with intrahepatic calculi were reviewed retrospectively to 1) determine the ability of MR to demonstrate intrahepatic calculi and 2) assess the MR appearance of the stones. In five out of six cases, MRI demonstrated intrahepatic calculi. In three cases, stones exhibited a low intensity signal on the different spin echo (SE) sequences, as previously described by in vitro and in vivo studies. However in two other cases, a significant signal with short T1 and relatively long T2 relaxation times was noticed. These different features are discussed in relation to chemical and physical differences in intrahepatic calculi and compared with variable CT attenuation values of stones. MRI seems to provide complementary information concerning intrahepatic calculi.

Adult↗
PubMedDate not supplied

[Morphological diagnosis of pseudocystic tumors of the liver].

Ten cases of pseudocystic hepatic tumors were observed during the past ten years. This entity is very rare in comparison with benign hepatic cysts. Careful analysis of the characteristics of these lesions usually allows to differentiate them from benign cysts. Of importance are wall thickness, mural nodules and fluid/fluid levels on ultrasound and/or computed tomography scanning. In our series, sonography depicted the true morphology of these cystic masses more clearly than computed tomography. If definitive diagnosis cannot be made by morphologic examinations, percutaneous aspiration of the cystic lesion, a simple and safe method, should be considered.

Angiography↗
PubMedDate not supplied

Ultrasonography, angiography, computed tomography and magnetic resonance in nodular regenerative hyperplasia of the liver: report of a pseudo-tumoral case.

Ultrasonographic, computed tomographic, and angiographic abnormalities of nodular regenerative hyperplasia have been described in very few cases. We report here the case of a 50-year-old man with round, well-limited hypoechogenic lesions involving the two lobes of the liver, and hypervascular, poorly delineated angiographic lesions. Computed tomography and magnetic resonance of the liver were normal. Histological examination of large liver specimens provided by intraoperative biopsy allowed the diagnosis of nodular regenerative hyperplasia. Such a pseudo-tumoral ultrasonographic and angiographic pattern must be recognized in order to avoid diagnostic and therapeutic mistakes, especially since percutaneous liver biopsy usually fails to diagnose this disease.

Biopsy↗
PubMedDate not supplied

[IgA and its different molecular forms in the mesenteric, portal and peripheral venous blood in man].

The aim of this study was to assess the role of mesenteric blood in polymeric IgA (p-IgA) and IgA2-transport from the intestinal mucosa into plasma and the role of the liver in the clearance of these molecular forms of IgA. The concentrations of IgA, p-IgA and IgA2 were measured in mesenteric, splenic, portal, and hepatic veins of 7 control subjects without liver disease and in portal and peripheral veins of 4 patients with alcoholic cirrhosis. In control subjects, the concentration of the different molecular forms of IgA were not significantly different in mesenteric and in splenic vein. No significant decrease of IgA concentrations was observed in hepatic vein, as compared with portal vein. In cirrhotic patients IgA concentrations were significantly higher than in control subjects, but concentrations of IgA, p-IgA and IgA2 were not different in portal and peripheral blood. These results show that mesenteric vein is not a major way for p-IgA and IgA2 from the gut lamina propria to plasma, and suggest that the origin of a significant part of these molecular forms of IgA could be peripheral lymph-nodes more than gut-associated-lymphoid-tissue. The absence of significant clearance of p-IgA by the liver in normal subjects suggests that abnormalities of hepato-biliary transport of p-IgA is not responsible for the increased IgA levels observed in cirrhotic patients.

Adult↗
PubMedDate not supplied

[Highly selective arteriography and embolization in the treatment of angiodysplasias with shunt, in the limbs (author's transl)].

The authors discuss the role of highly selective arteriography and embolization in the treatment of angiodysplasias with shunt, in the limbs, after analyzing the results in three cases of embolization for congenital arterio-venous fistula of the limbs. They review the arteriographic data necessary for a better understanding of the physiopathology and compare the different therapeutic methods available. The importance of highly selective arteriography in guiding therapy, where embolization is of primary value, is stressed.

Adult↗