Biomedical subjects
A Robertson
Publications and source records attributed to A Robertson.
Ice-breakers. Helping antenatal classes to warm up.
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Obstetric interventions explained.
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Cloning and molecular characterization of a cross-homologous zinc finger locus ZNF204.
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Wealth, equity and health care: a critique of a "population health" perspective on the determinants of health. Critical Social Science Group.
In this paper we examine the recent ascendancy of a "population health" perspective on the "determinants of health" in health policy circles as conceptualized by health economists and social epidemiologists such as Evans and Stoddart [Evans and Stoddart (1990) Producing health, consuming health care. Social Science & Medicine 31(12), 1347 1363]. Their view, that the financing of health care systems may actually be deleterious for the health status of populations by drawing attention away from the (economic) determinants of health, has arguably become the "core" of the discourse of "population health". While applauding the efforts of these and other members of the Canadian Institute for Advanced Research for "pushing the envelope", we nevertheless have misgivings about their conceptualization of both the "problem" and its "solutions", as well as about the implications of their perspective for policy. From our critique, we build an alternative point of view based on a political economy perspective. We point out that Evans and Stoddart's evidence is open to alternative interpretations--and, in fact, that their conclusions regarding the importance of wealth creation do not directly reflect the evidence presented, and are indicative of an oversimplified link between wealth and health. Their view also lacks an explicit substantive theory of society and of social change, and provides convenient cover for those who wish to dismantle the welfare state in the name of deficit reduction. Our alternative to the "provider dominance" theory of Evans and Stoddart and colleagues stresses that the factors or forces producing health status, which Evans and Stoddart describe, are contained within a larger whole (advanced industrial capitalism) which gives the parts their character and shapes their interrelationships. We contend that this alternative view better explains both how we arrived at a situation in which health care systems are as costly or extensive as they are, and suggests different policy avenues to those enunciated by Evans, Stoddart and their confrères.
Critical reflections on the politics of need: implications for public health.
This paper presents a case for an underlying language of need consistent with public health's commitment to social justice. After examining the problem of human need as it has been conceptualised historically, this paper argues that the problems of needs--a central concern in the modern welfare state--are inherently political. Two ways of conceptualizing need which have dominated the recent discourse on need--namely a therapeutic language of need and rights talk--are examined and found to be unsatisfactory in capturing the sense in which needs and their definition and arbitration are central to the life of the community. What is required for public health is a language of need which speaks to the reciprocity and interdependence which characterise community; such a language is to be found in a "moral economy of interdependence". The paper concludes by discussing what a moral economy of interdependence, as a language of need consistent with the aims of public health, might look like.
Inductive analysis methods applied on questionnaires.
The am of this study was to evaluate subjective aspects from questionnaires dealing with dental trauma by applying different computerized inductive techniques within the field of artificial intelligence to questionnaires consisting of descriptive variables and of questions reflecting functional, personal, and social effects of patients' oral situation following dental trauma. As the methodology used is new to many readers in odontologic sciences, a detailed description of both the processes and the terminology is given. Utilizing a neural network as a first step in an analysis of data showed if relations existed in the training set, but the network could not make the relations explicit, so other methods, inductive methods, had to be applied. Inductive methods have the potential constructing rules from a set of examples. The rules combined with domain knowledge can reveal relations between the variables. It can be concluded that the usage of methods based on artificial intelligence can greatly improve explanatory value and make knowledge in databases explicit.
A retrospective evaluation of patients with uncomplicated crown fractures and luxation injuries.
This paper is a review of the clinical findings from my thesis "Pulp survival and hard tissue formation subsequent to dental trauma". Traumatic injuries in children and adolescents are a common problem, and the prevalence of such injuries has increased over the last 10-20 years. The purpose of the present investigations was to evaluate the long-term results following uncomplicated crown fractures and luxations involving subsequent pulp canal obliteration. A total of 241 patients with 545 injured teeth were available for clinical examination, of whom 102 answered a questionnaire and were interviewed before oral examination. In addition, 82 permanent incisors presenting with pulp canal obliteration were followed for a period of 7 to 22 years (mean 16 years). The findings showed little pulpal response to crown fracture and subsequent restorative procedures as long as there was no concomitant periodontal injury (15-year follow-up). Approximately every fourth resin composite filling was rated as unacceptable at clinical examination. The interview showed that half of the individuals were dissatisfied with the color and/or anatomic form of the composite restoration. Pulp canal obliteration was found in all luxation categories, and 69% of the teeth demonstrated yellow crown discoloration. According to the survival curve the 20-year pulp survival rate diagnosed radiographically was 84%. Although the risk of pulp necrosis increased with time, routine endodontic intervention of teeth with ongoing pulp canal obliteration of the root canal did not seem justified.
Risks of silicosis in coalworkers exposed to unusual concentrations of respirable quartz.
OBJECTIVES: To describe the radiographic changes in coalworkers exposed to unusual concentrations of respirable quartz during the 1970s, and to relate these to exposure measurements. METHODS: Men who had worked at one Scottish colliery during the 1970s were invited to a health survey. Chest radiographs were taken from 547 subjects. Classifications of these films under the International Labour Organisation (ILO) 1980 scheme were related, by logistic regression, to existing data on individual men's exposures to respirable dust and quartz. RESULTS: Taking the median of the three readers' results on profusion of small opacities, 203 men (38%) showed progression of at least one profusion category on the 12 point scale, from the various 1970s surveys to the follow up in 1990-1. A total of 158 men (29%) had a profusion of at least 1/0, and 47 (8.6%) of at least 2/1 at the follow up survey. Large opacities were recorded as present by at least two readers for 14 (2.6%) of the men. Profusion of small opacities was strongly related to exposures experienced in the 1970s, and more strongly for quartz than for the non-quartz fraction of the dust. Estimates of risk are presented over the range of quartz exposures experienced. CONCLUSIONS: The quartz exposures experienced by some men at this colliery have caused considerable progression of radiographic abnormalities since exposure ended. The data accumulated offer opportunities for further more detailed analyses to inform debate on occupational limits for quartz exposures, both in collieries and in other industries where there is exposure to quartz in mixed dust.
Domiciliary nebuliser therapy--a valuable option in chronic asthma and chronic obstructive pulmonary disease?
Domiciliary nebulisers are in widespread use for patients who have severe chronic airways disease, both asthma and chronic obstructive pulmonary disease (COPD). We report a study of the use of domiciliary nebulisers designed to assess practical problems and the value of such therapy in preventing hospital admissions. A total of 405 patients underwent a structured interview at home and their case records were reviewed. Technical performance of the nebuliser compressors was assessed. The mean (SD) age of those interviewed was 64.5 (12) years. 185 patients had a physician diagnosis of asthma, and 208 had COPD. 87% patients used their nebuliser at least once daily. Side effects, reported by 54%, were related to frequency of use and commoner in younger patients. 29 subjects (7%) died within 2 years of receiving their nebuliser. Among the survivors, the 2 year periods before and after supply of the nebuliser were compared. The percentage of patients requiring hospital admission for exacerbations of lung disease fell from 56% to 46% (p < 0.01) but the number and duration of admissions was unchanged. Those whose admission duration increased had more severely impaired spirometry when the nebuliser was supplied and had lower activity scores and higher breathlessness scores at the time of interview indicating more severe disease. Approximately half of the compressors were malfunctioning and patients' understanding of the principles of nebuliser treatment was poor. The provision of domiciliary nebuliser can influence hospital admission in patients with obstructive airways disease. There is also a need for improved patient education and for technical support which may require the development of a nurse-run nebuliser service.
Health and productivity of older workers.
The purpose of this paper is to present a summary of a critical review of the literature on age, health, and work. The health of older workers is a concern to the extent that the productivity of older workers is considered to be a function of age-related health, the general conclusion being that age-related declines in health inevitably lead to decreased productivity. This paper investigates the implications of age-related physiological and psychological changes on the productivity of older workers, by focusing on a critical examination of the ways in which productivity has been conceptualized and operationalized. This paper concludes that the emerging concept of "work capacity" has the greatest potential for addressing the productivity issues of workforce aging. Implications for public and corporate policy and for further research are also examined.
Health, food, and nutrition policy.
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Urodynamic and clinical effects of noninvasive and minimally invasive treatments in elderly men with lower urinary tract symptoms stratified according to the grade of obstruction.
OBJECTIVES: We investigated the symptomatic and urodynamic effects of several noninvasive and minimally invasive treatment modalities to quantify these effects and to compare subjective and objective results within groups with various degrees of obstruction. METHODS: In a prospective study at one center, 487 patients who completed a full screening program including urodynamic investigation started treatment with watchful waiting, terazosin, transurethral microwave thermotherapy, or laser treatment of the prostate; they were re-evaluated symptomatically and urodynamically after 6 months of therapy. The symptomatic and urodynamic results of 87 patients from another center who underwent transurethral resection of the prostate and who had their second urodynamic evaluation 6 months after surgery were also included. RESULTS: In patients without bladder outlet obstruction (BOO), improvement in maximum flow and symptom scores with little change in the degree of obstruction was most apparent, whereas a decrease of detrusor pressure at maximum flow was observed mainly in patients with BOO. The urodynamic effect but not the symptomatic effect of treatments depended on the initial grade of BOO. Urodynamic changes were more marked in the minimally invasive treatment groups compared with the noninvasive treatment groups. CONCLUSIONS: In symptomatic patients with benign prostatic hyperplasia, symptomatic improvement in the short term does not seem to depend on changes in urodynamic parameters. Future well-controlled studies focusing on the durability of symptomatic and urodynamic effects will be needed to illustrate the relative potential of urodynamic and other clinical parameters to predict a favorable response to current and innovative treatments.
Genetically variable triplet repeats in a RING-finger ORF of Helicoverpa species baculoviruses.
Nucleotide sequence analysis of the Helicoverpa zea S-type nucleopolyhedrovirus (HzSNPV) genomic interval between the polh and iel genes has revealed an open reading frame (HOAR ORF) that contains a complex A 1-T rich triplet repeat region (RAT-repeats). HOAR ORF is predicted to encode an acidic, arginine residue rich. 712 aa protein, with a C3HC4 (RING-finger) zinc binding motif. RAT-repeats, distributed over 450 bp. consist of GAT. AAT, and GTT codons, correspond to Asp, Asn and Val residues which display an extreme codon bias not seen with nine other genes of this virus. A survey of four other (field) isolates of Helicoverpa sp. NPVs confirms a high incidence of mutation in the RAT-repeat region. A 158-bp conserved block, homologous to the pe38-ien promoter of AcMNPV, was identified upstream of HOAR ORF. The sub-region of the genome in which HOAR ORF is located is susceptible to rearrangement.
A retrospective evaluation of traumatized permanent teeth.
The purpose of this retrospective study (15 years follow-up) was to evaluate the long-term results of treatment to injured teeth following acute trauma. A total of 198 patients with 488 injured teeth were available for analysis. Uncomplicated crown fractures were restored with composite restorations in 106 teeth. 19% of the restorations had been replaced more than 10 times and at the final examination approximately 25% were rated as unacceptable, i.e. needing clinical treatment. Fixed prosthetic therapy had been provided for 106 teeth and endodontic treatment had been provided in 114. Colour changes appearing at late stage suggested obliteration, necrosis or endodontically treated teeth. Anterior composite restorations have been considered acceptable as semi-permanent restorations in patients of early school age (7-15 years), and may have been an advance on what was possible previously, but results of this clinical study suggest that they still do have major shortcomings. There remains a need for a simple, conservative method of restoring aesthetics to fractured and discoloured anterior teeth for clinical use in young patients of late school age.
Pulp calcifications in traumatized primary incisors. A morphological and inductive analysis study.
The purpose of this study was to investigate histopathological changes in primary teeth following trauma, and to look for possible correlations between the morphology of pulpal calcification and clinical findings. The material consisted of 123 primary teeth from 98 Danish children aged 9-108 months (mean age 33.5 +/- 19.7 months) at the time of injury. The specimens were analyzed by means of light and scanning and transmission electron microscopy. Data from the clinical investigation and from predetermined ranked parameters from the histological analysis were processed in a computerized inductive analysis program. The results, describing patterns of co-variation, are presented as a decision tree. The most common diagnosis was intrusion luxation (54%). In 41% of all teeth, the degree of obliteration was less than 1/4 of the pulpal lumen. In most cases (79%), no denticles were visible. When present, 80% of the denticles had a bone-like appearance. Tissues occluding the pulpal lumen were either dentin-like (49%), bone-like (19%), or fibrotic (9%). It could be concluded that these varying responses could not be correlated with explicit clinical diagnoses. However, in certain combinations, histological parameters could be correlated to clinical findings.
Subjective aspects of patients with traumatized teeth. A 15-year follow-up study.
The aim of this study was to obtain detailed information about adults who suffered trauma to the teeth as children. A total of 102 patients took part. The patients answered a questionnaire and were interviewed before the oral examination. Thirty-nine per cent of the patients reported dissatisfaction either with the color and/or anatomic form of the traumatized teeth or reconstruction. Most of the individuals did not remember having received any information about prognosis for the traumatized teeth. Twenty-one per cent of the patients remembered pain during treatment, and 25% remembered only the behavior and attitudes of the dental team. It can be concluded that all dental treatment in children with traumatized teeth must be carried out as painlessly as possible, and the dental team should minimize discomfort during the treatment. Good knowledge about traumatology and management can reduce stress and anxiety for both the patient and the dental team.
Pulp survival and hard tissue formation subsequent to dental trauma. A clinical and histological study of uncomplicated crown fractures and luxation injuries.
Traumatic injuries in children and adolescents are a common problem, and the prevalence of such injuries has increased over the last 10-20 years. The purpose of the present investigation was to evaluate long-term results following uncomplicated crown fractures and luxations involving subsequent pulp canal obliteration. A total of 198 patients with 488 injured permanent teeth were available for clinical examination (15 year follow-up), of which 102 also answered a questionnaire and were interviewed before oral examination. Further, 82 permanent incisors presenting with pulp canal obliteration (PCO) were followed for a period of 7 to 22 yr. (mean 16 yr.). The histological evaluation of luxation injuries was performed on 123 primary teeth from 98 patients. In the experimental study (crown fractures), 64 monkey permanent maxillary and mandibular central incisors and canines were subjected to different treatment alternatives at the time of fracture. The findings in the follow-up study showed very little pulpal response to crown fracture and subsequent restorative procedures as long as there was no concomitant periodontal injury. Approximately every fourth resin composite restoration was rated unacceptable at the clinical examination. The interview showed that half of the individuals were dissatisfied with the color and/or anatomic form of the composite restoration. PCO was found in all luxation categories, and according to the survival curve, the 20-year pulp survival rate diagnosed with X-ray was 84%. Although the risk for pulp necrosis (PN) increased with time, routine endodontic intervention of teeth with ongoing PCO of the root canal did not seem justified. The histological study showed that changes in dentin were represented by occlusion of the dentinal tubules and deposition of tertiary dentin. The tertiary dentin were classified as either dentin-like, bone-like or fibrotic. In the experimental study, few changes were observed in the pulp 3 months after crown fractures, irrespective of treatment alternative.