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Biomedical subjects

A Rinaldi

Publications and source records attributed to A Rinaldi.

185 records · Page 11Linked to original sources
PubMedDate not supplied

[Glycosylated hemoglobins and erythrocyte 2,3-diphosphoglycerate in diabetes mellitus].

Investigations carried out on 43 diabetic not ketoacidotic patients (32 women and 11 men) showed that the percentage of glycosylated hemoglobins (GHb) is significantly (p less than 0.01) inversely related to the intra-erythrocytic concentration of 2,3-DPG and to the calculated P50. Preliminary data from a prospective study suggest that the inverse relationship could be referred to the degree of control of the disease. In poorly controlled diabetes, where at the highest percentages of GHb the lowest levels of 2,3-DPG are found, less oxigen can be delivered to peripheral tissues.

2,3-Diphosphoglycerate↗
PubMedDate not supplied

Synthesis and chromatographic properties of cysthationamine. A substrate for diamineoidase.

Details are reported for the preparation of the 2-aminoethyl, 3-aminopropyl sulfide from 3-bromopropylamine and 2-mercaptoethylamine. For this compound, the shorter name cystathionamine is proposed. The corresponding sulfoxide and sulfone have been also prepared. Some analytical data and chromatographic properties are reported. Preliminary results show that cystathionamine is a good substrate for the pig kidney diamineoxidase.

Amine Oxidase (Copper-Containing)↗
PubMedDate not supplied

Synthesis of selenocystathionamine and preliminary data on its oxidation by diamineoxidase.

Details are reported for the synthesis of selenocystathionamine, the 2-aminoethyl, 3-aminopropyl selenide, NH2CH2CH2-Se-CH2CH2CH2NH2. Paper and ion exchange chromatographic behaviour of the compound has been investigated. By automated ion exchange chromatography on a sulfonated resin selenocystathionamine may be easily differentiated from cystathionamine, cystamine and selenocystamine. It has been shown that selenocystathionamine is oxidatively deaminated by pig kidney diamineoxidase. Preliminary data indicate that the first product of the reaction is a cyclized aminoaldehyde which then undergoes further degradation.

Amine Oxidase (Copper-Containing)↗
PubMedDate not supplied

Oxidation of selenocystamine by diamineoxidase.

Selenocystamine is oxidatively deaminated by pig kidney diamineoxidase. The first product of the reaction is the corresponding cyclized aminoaldehyde, selenocystaldimine, which then undergoes further degradation. The oxidative deamination is thus the first step of a series of cyclic reactions which give rise to extensive cleavage of selenocystamine.

Amine Oxidase (Copper-Containing)↗