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Biomedical subjects

A Rico

Publications and source records attributed to A Rico.

35 records · Page 2Linked to original sources
PubMed1979

[Elaboration of an in vivo model, in half life size, for aeronautical purposes].

Toxic effects of combustion products originating from plane cabin constituents are studied, in vivo, in Rats. The model associates an important combustion room, and an experience room containing eight revolving cages for Rats; these cages allow a remote control of the movements of the Rats which can be electrically stimulated and ejected. Such a device permits to study the incapacitance, i.e. the inability to move. For the combustion of a seat, without ventilation, incapacitation appears in 2 to 6 min. Biochemical screening demonstrates on increase of pCO2, carboxyhemoglobin and glycemia and a decrease of pO2.

Animals↗
PubMed1979

[Protection against mercuric chloride nephropathy by sodium selenite in the rat].

Daily intraperitoneal injection of 2.5 or 5 mumole HgCl2 to male Rats weighing 250 to 350 g induces an early intense increase of urine gamma-glutamyl transferase activity. In the same conditions, equimolecular administration of sodium selenite and mercuric chloride induces no increase of the enzymuria for the low dose: for the high dose- a minor and more persistent increase of urine GGT is observed. Thus, the activity of urines GGT allows, in vivo, to establish that sodium selenite protects Rat kidney against toxic effects of mercuric chloride.

Animals↗
PubMed1978

[Changes in the distribution of gamma-glutamyl transferase in the organs of the mouse as a function of development].

In the Mouse, gamma-glutamyl transferase distribution changes with development in the kidney and the liver; on the contrary, its activity remains almost equal and low in other organs. In the liver, a low activity is observed in the fetus and the new-born up to the 3rd day of life; then it is no more measurable. In the kidney, the low enzyme activity of the fetus is multiplied by 10 in the 10 first days of life and by 50 in the 6 first weeks.

Animals↗
PubMedDate not supplied

[Decentralization: part of the health system problem or the solution?].

The greatest change experienced by the Spanish health system in the last two decades has probably been the devolution of power to the autonomous communities composing the Spanish state. This may generate tensions in the status quo and poses questions of whether decentralization of the health system is compatible with a cohesive national health system and whether this devolution of power is part of the problem of the health system or part of its solution. Generalized devolution occurring as rapidly as that produced in Spain (negotiated in slightly less than 6 months, with minimal financial agreements, without explicit legal frameworks in the areas of coordination and development of basic norms, and with a new agreement of general financing of the autonomous communities which possibly contains lacunae, etc.) presents an uncertain panorama. The possible misuse of the wide powers recently transferred to the autonomous communities could easily be used by those who would like to see a restoration of pre-democratic centralism to sow fear of the collapse of the health service as the cornerstone of the welfare state among the general public. The present article briefly addresses these questions.

Delivery of Health Care↗
PubMedDate not supplied

Bioactivation and bound residues.

Most toxic chemicals undergo bioactivation before they can exert their noxious effects. These biotransformations produce very reactive intermediate metabolites which covalently bind to vital cellular components and can lead to a specific toxicity. Several categories of reactive metabolites can be postulated: (1) electrophilic compounds, (2) free radicals, (3) compounds able to form activated species of oxygen (oxidative stress). Only the two first groups covalently bind to cellular components; these adducts are a part of the bound residues of veterinary drugs. Electrophilic metabolites react with nucleophilic centres of various molecules (proteins, nucleic acids, amino-acids . . .). These active intermediates (oxiranes, quinoneimines, carbo cations . . .) appear during oxidation reactions specifically catalysed by the microsomal mixed-function oxidase. Hepatic necrosis induced by Acetaminophen can be a model and will be discussed. Free radicals are also produced by microsomal metabolism. They bind covalently to cellular lipids and proteins and induce a lipidic peroxidation. Carbon tetrachloride-induced hepatic injury is an example. These concepts dealing with bioactivation, the nature of the covalents' adducts and their toxicological significance are essential to assess the toxicity of both parent drugs and their residues.

Acetaminophen↗
PubMedDate not supplied

Plasmodium yoelii: identification of a gene encoding a putative ADP-ribosylation factor-1 GTPase-activating protein, PyAG1.

The PyAG1 gene, identified by the screening of a Plasmodium yoelii genomic DNA library with a rhoptry-specific Mab, encodes a protein with a zinc finger structure immediately followed by the consensus sequence of the Arf GAP catalytic site. The serum of mice immunized with the recombinant protein recognized specifically the rhoptries of the late infected erythrocytic stages. Blast analysis using the Genbank database gave the highest scores with four proteins presenting an Arf1 GAP activity. If presenting also this activity, the PyAG1 protein could be involved in the regulation of the secreted protein vesicular transport and, consequently, in the rhoptry biogenesis.

ADP-Ribosylation Factor 1↗
PubMedDate not supplied

[Myringoplasty].

Explore the source record for details and available documents.

Catheterization↗