Biomedical subjects
Publications and source records attributed to A Renard.
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Incubation of O6-[3H]ethylguanine-containing DNA with a rat liver chromatin fraction resulted in a decrease in the O6-ethylguanine content of the DNA. Analysis of the products of this reaction showed that the ethyl group had been transferred from the O6-ethylguanine to a protein acceptor. When the incubation mixture was separated on a cesium chloride gradient, the radioactivity removed from O6-ethylguanine appeared in a low-density band. This material has been isolated and subjected to trypsin digestion and high-pressure liquid chromatography analysis; it was sensitive to trypsin and the digest contained new high-pressure liquid chromatography peaks characteristic of oligopeptides. Radioactive peaks from the trypsin digestion have been digested further to the amino acid level and have been shown to contain S-[3H]ethylcysteine. Thus, we conclude that the repair activity in rat liver chromatin removes the ethyl group from O6-ethylguanine and transfers it to a cysteine moiety contained in an acceptor protein.
A postauricular flap based on its dermal pedicle has been described for reconstruction of traumatic or iatrogenic defects of the external ear. The versatility of this flap allows its use for centrally as well as peripherally located defects. In selected cases, this technique may find its application. Three patients have been discussed and have had at least 2 years of follow-up and good postoperative results.
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An electron-capture GLC method to measure nofedone in human serum was developed. A homolog of nofedone was added to the serum as an internal standard before the sample was alkalinized with pH 9.5 phosphate buffer and extracted with ethylene dichloride containing 0.5% isopentyl alcohol. This organic phase was extracted with 0.2N HCl, the acidic aqueous phase was neutralized immediately, and the extraction with ethylene dichloride was repeated. The ethylene dichloride phase was evaporated to dryness, and the residue was reacted with heptafluorobutyric anhydride. The derivatives were chromatographed at 290 degrees on a 1% Dexsil 300 column. Data on apparent recovery, accuracy, and specificity are given. The detection limit was 5 ng/ml of serum. Serum levels over time in one patient after intravenous administration of 1 mg/kg and after oral administration of 50, 100, and 150 mg of nofedone are presented.
Secnidazole, a derivative of 5-nitro imidazole exhibits trichomonacid, amoebicid and antimicrobial properties; it has been studied in view of its biological fate in healthy volunteers (man and woman) comparatively with tinidazole. Both products were administered orally to the same volunteers at the single dose level of 2 g. The seric concentrations and the pharmacokinetic profile were determined up to the 72nd hour after drug administration. The whole urinary excretion (unchanged product + metabolites) during the same period was determined in percent of the administered dose level. Secnidazole is particularly different from tinidazole owing to its slower blood clearance. The apparent average half-life in the ten volunteers (5 men and 5 women) is about 17 hours for secnidazole and 13 hours for tinidazole. However, for both drugs, a difference between men and women was demonstrated: in female volunteers, the decrease in blood concentrations occurs a little quicker than in male volunteers. Regarding urinary excretion, it is also a little greater in female volunteers than in male volunteers.
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We present a case of nasolabial cyst. The clinical and histological aspects are discussed and a new concept of the embryology of the nasolabial cyst in described.
This report discusses the first recorded patient in whom a trachea--innominate artery fistula after tracheostomy was treated successfully by resection of the eroded segment of artery followed by graft replacement using the patient's left innominate vein. The mechanism of vessel erosion and its prevention are discussed. Also, suitable methods are presented for obtaining temporary control of the severe hemorrhage associated with a tracheoarterial fistula while simultaneously maintaining an adequate airway.
This report is concerned with an analysis of 16 anastomotic aneurysms which developed in 12 patients after arterial surgery in which dacron sutures were used for all graft anastomoses. Knitted dacron grafts had been used in all but two of the original surgical procedures; a woven dacron graft had been used in one procedure and a saphenous vein graft in the other. The majority of anastomotic aneurysms occurred in the femoral triangle at the site of an end-to-side anastomosis. Five anastomotic aneurysms were caused by infection, and a variety of etiologic factors were responsible for the 11 non-infected aneurysms. Fourteen anastomotic aneurysms in 10 patients were treated surgically. A good result had been obtained in six patients; one patient required amputation of an extremity and three patients died postoperatively as a result of cardiac disease or pulmonary embolization. This report also contains a discussion of the factors affecting the occurrence of anastomotic aneurysms and a description of specific operative measures designed to decrease the incidence of these aneurysms.
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