Search PubMed⌕ Search

Biomedical subjects

A Rejthar

Publications and source records attributed to A Rejthar.

At least 73 records · Page 4Linked to original sources
PubMed1978

Prognostic significance of an enhanced number of T lymphocytes in chronic lymphatic leukemia.

Analysis of lymphocytes carried out by means of rosette tests in 24 patients treated for chronic lymphatic leukemia established the origin of malignant cells to be from Blymphocyte population. On the basis of a reactive T lymphocyte proliferation in patients with chronic lymphatic leukemia, a "coefficient of active T lymphocytes" has been deduced which proved to be a rapid indicator of a short-term prognosis. This coefficient may contribute in a substantial measure towards an objectivation of the indication of a repeated oncostatic therapy in relatively light leukocytosis or in otherwise clinically unresolved cases.

Female↗
PubMed1978

Establishment of cell line derived from human malignant melanoma.

A new human cell line of malignant melanoma (MJM) was established with the use of the in vitro fragment technique. It has been maintained over 34 months of continuous cultivation. Three types of cells can be recognized by light microscope. The epitheloid elements predominate, less frequent are fibroblastoid and giant multinuclear cells. The pigment production is not macroscopically visible. Over 60 per cent of analyzed metabphases showed hyperdiploid number of chromosomes, the rest was mostly tetra and hexaploid. No marker chromosomes were detected. The growth studies indicate the MJM cells have 63-hr doubling time. Cytochemistry revealed positive pigment or propigment granules in 36 per cent of cells. Ultrastructural studies did not detect melanin granules but some particles resembling atypical premelanosomes and melanosomes were recognized in some sections.

Cell Cycle↗
PubMed1977

Some remarks to the histological classification of malignant melanoma of the skin and its prognostic values.

Histological classification of human skin malignant melanoma as recommended by WHO melanoma group renders the first useful orientation in regard to the biological behavior of the tumor, but it cannot give any further clinical outlook. It would be therefore desiderable to complete the histological examinations with enzymatic and immunologic examinations performed during the treatment of the patient and thus try to gain a basis for a prognostic evaluation.

Humans↗
PubMed1976

Changes in human lymphocyte subpopulation in Hodgkin's lymphoma.

An investigation of 33 patients with Hodgkin's lymphoma--both treated and untreated--has revealed lymphocytopenia and a significant decline in the absolute number of T lymphocytes labeled with rosettes with sheep erythrocytes to be due in these patients not to the tumorous disease itself, but probably to the intensive nature of the therapy. A marked decline in the absolute number of B lymphocyte subpopulation, determined by the formation of rosettes with mouse erythrocytes, occurs during a fresh relapse of patients with an active Hodgkin's lymphoma. This decline is probably independent of the preceding treatment, of the clinical stage of the disease and of its histological type.

Adult↗
PubMed1976

Hodgkin's lymphoma -- prognosis as related to histology, clinical stage and treatment.

The rapid advances in modern chemotherapy and actinotherapy of Hodgkin's lymphoma and an improvement in its diagnosis have ushered in numerous novel procedures. This is a preliminary analysis of the results of treatment of 117 patients with actinotherapy, polychemotherapy, consisting of a chemotherapeutic four-combination as substitution for MOPP and a combined actino-chemotherapy. Actinotherapy was found more efficient in localized disorders of stages I and II, while polychemotherapy proved the more suitable when the disease was generalized -- stages III and IV. The analysis of our results has brought only partial support to the prognostic significance of the histological classification of Hodgkin's lymphoma according to Rye. No difference of statistical significance has been noted between the histological types of lymphocyte dominance, nodular sclerosis and mixed cellularity. Lymphocyte depletion alone showed a conspicuously worse prognosis than the other histological types.

Female↗
PubMed1975

Histological changes of terminal bronchioles in rats during the exposure to nitrogen dioxide.

At long-term exposure to 5 ppm NO2 (w/w), courses of histological changes in the epithelium of the terminal bronchioles of rats were observed. In the course of the experiment the first alterative changes were expressed by the loss of cilia and cell differentiation. The changes were followed by epithelial hyperplasia, leading to conspicuous narrowing of the lumen of bronchioles. After the phase of hyperplasia a phase of reparation followed, leading to the development of nonciliated epithelium without determinable Clara cells, with areas of uniform multi-layered epithelium. At the same time, in the longest interval of 11 weeks new alterative changes analogous to those found at the beginning of the experiment were observed.

Animals↗
PubMed1975

Nonspecific resistance to tumor allograft.

The effects of an increased volume of reticulohistiocyte system and macrophage activation in the recipient after treatment with BCG and Zymosan on the course of antitumor concomitant allograft-immunity reaction were studied. The results were verified on animals affected with immunosuppression due to whole body irradiation. A factor of essential significance for resistance to tumor allograft is an increase of the total number of small lymphocytes supplied by the transplantation of syngeneic spleen cells. A substantially lower efficiency was shown by prophylactic administration of BCG and Zymosan. Transplantation of macrophages syngeneic to the host failed to affect the latter's resistance to subsequent tumor allograft. The irradiated host's reactivity was regenerated with a suspesion of spleen cells of purified small lymphocytes, but transplantation of syngeneic macrophages remained without effect.

Adenocarcinoma↗